Guidelines of care for the management of atopic dermatitis: Section 2. Management and treatment of atopic dermatitis with topical therapies
Lawrence F. Eichenfield,Lawrence F. Eichenfield,Wynnis L. Tom,Wynnis L. Tom,Timothy G. Berger,Alfons Krol,Amy S. Paller,Kathryn Schwarzenberger,James N. Bergman,Sarah L. Chamlin,David E. Cohen,Kevin D. Cooper,Kelly M. Cordoro,Dawn Marie R. Davis,Steven R. Feldman,Jon M. Hanifin,David J. Margolis,Robert A. Silverman,Eric L. Simpson,Hywel C Williams,Craig A. Elmets,Julie Block,Christopher G. Harrod,Wendy Smith Begolka,Robert Sidbury +24 more
TLDR
Treatment of atopic dermatitis with nonpharmacologic interventions and pharmacologic topical therapies are reviewed and suggestions on dosing and monitoring are given based on available evidence.Abstract:
Atopic dermatitis is a common and chronic, pruritic inflammatory skin condition that can affect all age groups. This evidence-based guideline addresses important clinical questions that arise in its management. In this second of 4 sections, treatment of atopic dermatitis with nonpharmacologic interventions and pharmacologic topical therapies are reviewed. Where possible, suggestions on dosing and monitoring are given based on available evidence.read more
Citations
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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Eric L. Simpson,Thomas Bieber,Emma Guttman-Yassky,Lisa A. Beck,Andrew Blauvelt,Michael J. Cork,Jonathan I. Silverberg,Mette Deleuran,Yoko Kataoka,Jean-Philippe Lacour,Külli Kingo,Margitta Worm,Margitta Worm,Yves Poulin,Andreas Wollenberg,Yuhwen Soo,Neil M.H. Graham,Gianluca Pirozzi,Bolanle Akinlade,Heribert Staudinger,Vera Mastey,Laurent Eckert,Abhijit Gadkari,Neil Stahl,George D. Yancopoulos,Marius Ardeleanu +25 more
TL;DR: Dupilumab improved the signs and symptoms of atopic dermatitis, including pruritus, symptoms of anxiety and depression, and quality of life, as compared with placebo in two phase 3 trials of identical design.
Journal ArticleDOI
Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis.
Lawrence F. Eichenfield,Wynnis L. Tom,Sarah L. Chamlin,Steven R. Feldman,Jon M. Hanifin,Eric L. Simpson,Timothy G. Berger,James N. Bergman,David E. Cohen,Kevin D. Cooper,Kelly M. Cordoro,Dawn Marie R. Davis,Alfons Krol,David J. Margolis,Amy S. Paller,Kathryn Schwarzenberger,Robert A. Silverman,Hywel C Williams,Craig A. Elmets,Julie Block,Christopher G. Harrod,Wendy Smith Begolka,Robert Sidbury +22 more
TL;DR: This guideline addresses important clinical questions that arise in the management and care of AD, providing updated and expanded recommendations based on the available evidence.
Journal ArticleDOI
Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial
Andrew Blauvelt,Marjolein S. de Bruin-Weller,Melinda Gooderham,Jennifer Clay Cather,Jamie Weisman,David M. Pariser,Eric L. Simpson,Kim A. Papp,H. Chih ho Hong,Diana Rubel,Peter Foley,Errol P. Prens,Christopher E.M. Griffiths,Takafumi Etoh,Pedro Herranz Pinto,Ramon M. Pujol,Jacek C Szepietowski,Karel Ettler,Lajos Kemény,Xiaoping Zhu,Bolanle Akinlade,Thomas Hultsch,Vera Mastey,Abhijit Gadkari,Laurent Eckert,Nikhil Amin,Neil M.H. Graham,Gianluca Pirozzi,Neil Stahl,George D. Yancopoulos,Brad Shumel +30 more
TL;DR: This 1-year, randomised, double-blinded, placebo-controlled, phase 3 study aimed to evaluate the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical cortiosteroids in adults with moderate-to-severe atopic dermatitis.
Journal ArticleDOI
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial.
Diamant Thaçi,Eric L. Simpson,Lisa A. Beck,Thomas Bieber,Andrew Blauvelt,Kim A. Papp,Weily Soong,Margitta Worm,Jacek C Szepietowski,Howard Sofen,M. Kawashima,Richard Wu,Steven P. Weinstein,Neil M.H. Graham,Gianluca Pirozzi,Ariel Teper,E. Rand Sutherland,Vera Mastey,Neil Stahl,George D. Yancopoulos,Marius Ardeleanu +20 more
TL;DR: Dupilumab improved clinical responses in adults with moderate-to-severe atopic dermatitis in a dose-dependent manner, without significant safety concerns, and shows that IL-4 and IL-13 are key drivers of atopic skinitis.
Journal ArticleDOI
Anti-interleukin-31 receptor a antibody for atopic dermatitis
Thomas Ruzicka,Jon M. Hanifin,Masutaka Furue,Grazyna Pulka,Izabela Mlynarczyk,Andreas Wollenberg,Ryszard Galus,Takafumi Etoh,Ryosuke Mihara,Hiroki Yoshida,Jonathan W. Stewart,Kenji Kabashima +11 more
TL;DR: In this phase 2 trial, nemolizumab at all monthly doses significantly improved pruritus in patients with moderate‐to‐severe atopic dermatitis, which showed the efficacy of targeting interleukin‐31 receptor A.
References
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Adverse Effects of Topical Glucocorticosteroids
TL;DR: An updated review of local and systemic adverse effects upon administration of topical corticosteroids, including the latest FDA report on the safety of such steroids in children, is provided.
Journal ArticleDOI
Strength of Recommendation Taxonomy (SORT): A Patient-Centered Approach to Grading Evidence in the Medical Literature
Mark H. Ebell,Jay Siwek,Jay Siwek,Barry D. Weiss,Steven H. Woolf,Jeffrey Susman,Jeffrey Susman,Bernard Ewigman,Marjorie A. Bowman +8 more
TL;DR: A new grading scale that will be used by several family medicine and primary care journals and allowing readers to learn one taxonomy that will apply to many sources of evidence is developed, called the Strength of Recommendation Taxonomy.
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Systematic review of treatments for atopic eczema
TL;DR: An up-to-date coverage 'map' of randomised controlled trials (RCTs) of treatments of atopic eczema is produced to assist in making treatment recommendations by summarising the available RCT evidence using qualitative and quantitative methods.
Journal ArticleDOI
Guidelines for treatment of atopic eczema (atopic dermatitis) part I.
Johannes Ring,Agustín Alomar,T. Bieber,Mette Deleuran,A. Fink-Wagner,Carlo Gelmetti,U. Gieler,Jasna Lipozenčić,T. A. Luger,Arnold P. Oranje,Torsten Schäfer,T. Schwennesen,Stefania Seidenari,Dagmar Simon,Sonja Ständer,Georg Stingl,S. Szalai,Jacek C Szepietowski,Alain Taïeb,Thomas Werfel,Andreas Wollenberg,Ulf Darsow +21 more
TL;DR: The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal of Guidelines Research and Evaluation as discussed by the authors.
Journal ArticleDOI
Topical corticosteroid phobia in patients with atopic eczema
TL;DR: The need for provision of better information and education to patients and possibly general practitioners regarding the safety, potency and appropriate use of topical corticosteroids is highlighted.
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