Journal ArticleDOI
H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo.
Yanting Yang,Daokun Guan,Lei Lei,Jing Lu,Jia qi Liu,Gangqiang Yang,Chunhong Yan,Rong Zhai,Jingwei Tian,Yi Bi,Fenghua Fu,Hongbo Wang +11 more
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TLDR
H6 is a novel and potent MDR reversal agent, which has the potential to be administered in combination with conventional anticancer drugs and demonstrates robust reversal activity against MDR in vitro and in vivo.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2018-02-15. It has received 75 citations till now. The article focuses on the topics: Multiple drug resistance & P-glycoprotein.read more
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Structural and functional aspects of P-glycoprotein and its inhibitors.
TL;DR: This review presents up‐to‐date information on the structural and functional aspects of P‐glycoprotein and its known inhibitors and provides some information on drug discovery approaches for candidate P‐gp inhibitors.
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Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells
Xin Zhang,Yao Qin,Zhaohai Pan,Minjing Li,Xiaona Liu,Xiaoyu Chen,Guiwu Qu,Ling Zhou,Maolei Xu,Qiusheng Zheng,Defang Li +10 more
TL;DR: Results indicated that CBD could induce G0–G1 phase cell cycle arrest and apoptosis by increasing ROS production, leading to the inhibition of SGC-7901 cell proliferation, thereby suggesting that CBD may have therapeutic effects on gastric cancer.
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A targeted nanoplatform co-delivering chemotherapeutic and antiangiogenic drugs as a tool to reverse multidrug resistance in breast cancer.
Fengchun Tian,Fatima Zohra Dahmani,Jianan Qiao,Jiang Ni,Hui Xiong,Tengfei Liu,Jianping Zhou,Jing Yao +7 more
TL;DR: PLQ/GA nanoparticles provide a synergistic strategy for effective targeted co-delivery of chemotherapeutic and antiangiogenic agents and reversing MDR and metastasis in breast cancer.
Journal ArticleDOI
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
Hongfeng Wang,Nana Wang,Delai Xu,Qilian Ma,Yang Chen,Shiqiang Xu,Qin Xia,Yan Zhang,Jochen H. M. Prehn,Guanghui Wang,Zheng Ying,Zheng Ying +11 more
TL;DR: It is shown that multiple MiT-TFE transcription factors including TFEB, TFE3 and MITF, which are master regulators of autophagy and lysosomal biogenesis, can be activated upon direct cysteine oxidation by ROS.
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Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
TL;DR: Withaferin A is a bioactive compound with a remarkable anti‐cancer effect derived from Withania somnifera, commonly known as ashwagandha, but the anti-cancer mechanisms of WA in glioblastoma multiforme (GBM) are still unclear.
References
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LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
TL;DR: The LIGPLOT program automatically generates schematic 2-D representations of protein-ligand complexes from standard Protein Data Bank file input giving a simple and informative representation of the intermolecular interactions and their strengths, including hydrogen bonds, hydrophobic interactions and atom accessibilities.
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Targeting multidrug resistance in cancer
Gergely Szakács,Jill K. Paterson,Joseph A. Ludwig,Catherine Booth-Genthe,Michael M. Gottesman +4 more
TL;DR: Various approaches to combating multidrug-resistant cancer are described, including the development of drugs that engage, evade or exploit efflux by ABC transporters.
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Mechanisms of cancer drug resistance
TL;DR: The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance as mentioned in this paper.
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The Human ATP-Binding Cassette (ABC) Transporter Superfamily
TL;DR: The current knowledge of the human ABC genes, their role in inherited disease, and understanding of the topology of these genes within the membrane are reviewed.
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The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade.
TL;DR: The development of new compounds and the re-evaluation of compounds originally designed for other targets as transport inhibitors of ATP-dependent drug efflux pumps are summarized.