Journal ArticleDOI
HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions.
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TLDR
The data presented here demonstrate that pX entered into a protein-protein complex with the cellular transcriptional factors CREB and ATF-2 and altered their DNA binding specificities, which broadened the DNA binding specificity of these regulatory proteins.Abstract:
The hepatitis B virus (HBV) X gene product trans-activates viral and cellular genes. The X protein (pX) does not bind independently to nucleic acids. The data presented here demonstrate that pX entered into a protein-protein complex with the cellular transcriptional factors CREB and ATF-2 and altered their DNA binding specificities. Although CREB and ATF-2 alone did not bind to the HBV enhancer element, a pX-CREB or pX-ATF-2 complex did bind to the HBV enhancer. Thus, the ability of pX to interact with cellular factors broadened the DNA binding specificity of these regulatory proteins and provides a mechanism for pX to participate in transcriptional regulation. This strategy of altered binding specificity may modify the repertoire of genes that can be regulated by transcriptional factors during viral infection.read more
Citations
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Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway
TL;DR: A role for the JNK signal transduction pathway in transcriptional responses mediated by ATF2 is demonstrated and mutations in this pathway inhibited ATF2-stimulated gene expression mediated by the retinoblastoma tumor suppressor and the adenovirus early region 1A (E1A) oncoprotein.
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Hepatitis B Virus Biology
TL;DR: The state of knowledge in this very active field of hepatitis B viruses is reviewed with an emphasis on past accomplishments as well as goals for the future.
Journal ArticleDOI
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
T. Herdegen,J.D. Leah +1 more
TL;DR: This article reviews findings up to the end of 1997 about the inducible transcription factors c-Jun, JunB, JunD, c-Fos, FosB, Fra,1, Fra-2, Krox-20 (Egr-2) and Krox -24 (NGFI-A, Egr-1, Zif268) as they pertain to gene expression in the mammalian nervous system and describes their expression and possible roles in glial cells.
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Molecular recognition of protein-ligand complexes : applications to drug design
Babine Robert E,Steven L. Bender +1 more
Journal ArticleDOI
Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin
Qingqing Ding,Weiya Xia,Jaw Ching Liu,Jer Yen Yang,Jer Yen Yang,Dung Fang Lee,Dung Fang Lee,Jiahong Xia,Geoffrey Bartholomeusz,Yan Li,Yong Pan,Zheng Li,Ralf C. Bargou,Jun Qin,Chien-Chen Lai,Fuu Jen Tsai,Chang Hai Tsai,Mien Chie Hung,Mien Chie Hung +18 more
TL;DR: A mechanism by which HBV-X protein (HBX) upregulates beta-catenin through a docking motif of GSK-3beta is reported, which is supported by immunohistochemical staining in different human tumors, including cancers of the liver, breast, kidney, and stomach.
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