Herpes Infections and Dementia: Rebutting Alternative Fact.
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TLDR
Commentary in Neurotherapeutics critically addresses the earlier report by Tzeng et al. that aggressive antiviral treatment against herpes simplex virus (HSV) was associated with a later decrease in the incidence of Alzheimer’s disease (AD).About:
This article is published in Neurotherapeutics.The article was published on 2019-01-07 and is currently open access. It has received 6 citations till now.read more
Citations
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Journal ArticleDOI
The Alzheimer's Disease Exposome
TL;DR: The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD‐risk genetic variants.
Journal ArticleDOI
Alphaherpesvirus Latency and Reactivation with a Focus on Herpes Simplex Virus.
TL;DR: This review focuses on the concept that the tegument protein and viral transactivator VP16 plays a major role in the transition from latency to the lytic cycle.
Journal ArticleDOI
Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer's Disease.
Tamas Fulop,Shreyansh Tripathi,Serafim Rodrigues,Mathieu Desroches,Ton Bunt,Arnold R. Eiser,Francois P.J. Bernier,Pascale B. Beauregard,Annelise E. Barron,Abdelouahed Khalil,Adam Plotka,Katsuiku Hirokawa,Anis Larbi,Christian Bocti,Benoit Laurent,Eric Frost,Jacek M. Witkowski +16 more
TL;DR: In this paper, the changes in the brain antimicrobial immune response during aging and especially in AD sufferers serve as a foundation that could lead to improved treatment strategies for preventing or decreasing the progression of AD in a disease-modifying treatment.
Journal ArticleDOI
Interspecific interactions that affect ageing: Age-distorters manipulate host ageing to their own evolutionary benefits.
TL;DR: The concept of age-distorters is introduced in this paper, which is used to manipulate the biological age of other organisms upon which the reproduction of the ageing agent relies, e.g., viruses, parasites and symbionts.
Journal ArticleDOI
Alzheimer's Gone Viral: Could Herpes Simplex Virus Type-1 Be Stealing Your Memories?
Rhutuja Khokale,Ayesha Kang,Keri-Ann R Buchanan-Peart,Maxine L Nelson,Oluwatayo J Awolumate,Ivan Cancarevic +5 more
TL;DR: Anti-viral agents impede brain degeneration by preventing HSV1 spread and its replication, decreasing hyperphosphorylated tau and amyloid-β; thus providing an efficacious treatment for AD.
References
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Journal ArticleDOI
The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
Stephanie J. Soscia,James E. Kirby,Kevin J. Washicosky,Stephanie Tucker,Martin Ingelsson,Bradley T. Hyman,Mark Burton,Lee E. Goldstein,Scott Duong,Rudolph E. Tanzi,Robert D. Moir +10 more
TL;DR: The findings suggest Aβ is a hitherto unrecognized AMP that may normally function in the innate immune system and stands in stark contrast to current models of Aβ-mediated pathology and has important implications for ongoing and future AD treatment strategies.
Journal ArticleDOI
Recovery of Herpes-Simplex Virus from Human Trigeminal Ganglions
Baringer,Swoveland P +1 more
TL;DR: In six of seven patients, herpes-simplex virus was recovered from trigeminal ganglions obtained at autopsy from unselected cadavers less than 12 hours after death and maintained in culture for up to two weeks after death.
Journal ArticleDOI
Herpes simplex virus type 1 in brain and risk of Alzheimer's disease
Ruth F. Itzhaki,Woan-Ru Lin,Dazhuang Shang,Gordon K. Wilcock,Brian Faragher,Gordon A. Jamieson +5 more
TL;DR: The findings suggest that the combination of HSV1 in brain and carriage of an APOE-epsilon 4 allele is a strong risk factor for AD, whereas either of these features alone does not increase the risk of AD.
Journal ArticleDOI
Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.
Benjamin Readhead,Jean-Vianney Haure-Mirande,Cory C. Funk,Matthew A. Richards,Paul Shannon,Vahram Haroutunian,Vahram Haroutunian,Mary Sano,Mary Sano,Winnie S. Liang,Noam D. Beckmann,Nathan D. Price,Eric M. Reiman,Eric E. Schadt,Michelle E. Ehrlich,Sam Gandy,Joel T. Dudley +16 more
TL;DR: This study constructs multiscale networks of the late-onset AD-associated virome, and elucidates networks linking molecular, clinical, and neuropathological features with viral activity and indicates viral activity constituting a general feature of AD.
Journal ArticleDOI
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
Connie Celum,Anna Wald,Anna Wald,J.R. Lingappa,Amalia Magaret,Amalia Magaret,Richard S. Wang,Nelly Mugo,Nelly Mugo,Andrew Mujugira,Jared M. Baeten,James I. Mullins,James P. Hughes,Elizabeth A. Bukusi,Elizabeth A. Bukusi,Elizabeth A. Bukusi,Craig R. Cohen,Elly Katabira,Allan R. Ronald,James Kiarie,Carey Farquhar,Grace John Stewart,Joseph Makhema,Myron Essex,Edwin Were,Kenneth H. Fife,G de Bruyn,Glenda Gray,James McIntyre,Rachel Manongi,Saidi Kapiga,David Coetzee,Susan Allen,Mubiana Inambao,Kayitesi Kayitenkore,Etienne Karita,William Kanweka,Sinead Delany,Helen Rees,Bellington Vwalika,Wendy S. Stevens,Campbell,Katherine K. Thomas,Robert W. Coombs,Rhoda Ashley Morrow,William L. H. Whittington,M J McElrath,M J McElrath,Linda E Barnes,Renee Ridzon,Lawrence Corey,Lawrence Corey +51 more
TL;DR: Daily acyclovir therapy did not reduce the risk of transmission of HIV-1, despite a reduction in plasma HIV- 1 RNA of 0.25 log(10) copies per milliliter and a 73% reduction in the occurrence of genital ulcers due to HSV-2.