Journal ArticleDOI
Histone deacetylase inhibitors.
TLDR
Design of a second generation ofHDACs was based upon data affording potent HDACs such as LAQ824 and PDX101 currently under phase I clinical trials, and two of them, MS-275 and CI-994, have reached phase II and I clinical Trials, respectively.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2005-01-01. It has received 819 citations till now. The article focuses on the topics: Histone deacetylase & Phenylbutyrate.read more
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A Convenient Synthesis of the New Histone Deacetylase Inhibitor Scriptaid
Mariana Gerova,Ognyan I. Petrov +1 more
TL;DR: A recent in vitro study revealed that scriptaid provoked growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells, confirming the effect of scriptaid as HDAC inhibitor.
Journal ArticleDOI
Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3–H4 histones and lamin-B receptor
TL;DR: It is found that the anti-HP1β intrabody sequesters HP1β into cytoplasmic aggregates, inhibiting its traffic to the nucleus, providing new insights into the mode of action of cytopLasmic-targeted intrabodies and the interaction between HP1 β and its binding partners involved in peripheral heterochromatin organisation.
BookDOI
Cell Signaling & Molecular Targets in Cancer
Malay Chatterjee,Khosrow Kashfi +1 more
TL;DR: Book of cell signaling molecular targets in cancer, as an amazing reference becomes what you need to get, as a source that may involve the facts, opinion, literature, religion, and many others are the great friends to join with.
Journal ArticleDOI
The Effect of Sodium Butyrate on Adventitious Shoot Formation Varies among the Plant Species and the Explant Types.
Myoung Hui Lee,Jiyoung Lee,Seung Hee Choi,Eun Yee Jie,Jae Cheol Jeong,Cha Young Kim,Suk Weon Kim +6 more
TL;DR: The effect of NaB on adventitious shoot formation and expression of CYCD3-1 and WUS genes depended on the plant species and whether the effects were tested on explants or protoplast-derived calli.
Journal ArticleDOI
FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors
Levi Hc Makala,Salvatore Di Maro,Salvatore Di Maro,Tzu-Fang Lou,Sharanya Sivanand,Jung-Mo Ahn,Betty S. Pace +6 more
TL;DR: Investigation of the ability of FK228 analogues to induce HbF using a novel KU812 dual-luciferase reporter system supports lead compounds as potential therapeutic agents for further development in the treatment of SCD.
References
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Journal ArticleDOI
Crystal structure of the nucleosome core particle at 2.8 Å resolution
TL;DR: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it.
Journal ArticleDOI
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Homayoun Vaziri,Scott K. Dessain,Scott K. Dessain,Elinor Ng Eaton,Shin-ichiro Imai,Roy A. Frye,Tej K. Pandita,Leonard Guarente,Robert A. Weinberg +8 more
TL;DR: It is proposed that hSir2, the human homolog of the S. cerevisiae Sir2 protein known to be involved in cell aging and in the response to DNA damage, binds and deacetylates the p53 protein with a specificity for its C-terminal Lys382 residue.
Journal ArticleDOI
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Jianyuan Luo,Anatoly Y. Nikolaev,Shin-ichiro Imai,Delin Chen,Fei Su,Ariel L. Shiloh,Leonard Guarente,Wei Gu +7 more
TL;DR: It is shown that mammalian Sir2alpha physically interacts with p53 and attenuates p53-mediated functions, and Nicotinamide inhibits an NAD-dependent p53 deacetylation induced by Sir2 alpha, and also enhances the p53 acetylation levels in vivo.
Journal ArticleDOI
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.
TL;DR: Results clearly indicate that TSA is a potent and specific inhibitor of the histone deacetylase and that the in vivo effect of TSA on cell proliferation and differentiation can be attributed to the inhibition of the enzyme.
Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.