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Histone post-translational modifications — cause and consequence of genome function
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TLDR
This Review explores the contribution of histone PTMs to the regulation of genome function by discussing when these modifications play a causative (or instructive) role in DNA-templated processes and when they are deposited as a consequence of such processes, to reinforce and record the event.About:
This article is published in Nature Reviews Genetics.The article was published on 2022-03-25. It has received 89 citations till now. The article focuses on the topics: Medicine.read more
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Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
TL;DR: In this article , the authors summarize the knowledge on epigenetic history and essential regulatory mechanisms in cardiovascular diseases, and discuss the preclinical studies and drugs that are targeted these epigenetic key enzymes for cardiovascular diseases therapy.
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Polyphenols as Potent Epigenetics Agents for Cancer
Peramaiyan Rajendran,Salaheldin Abdelsalam,Kaviyarasi Renu,Vishnu Priya Veeraraghavan,Rebai Ben Ammar,Emad A. Ahmed +5 more
TL;DR: The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized and the potential of polyphenolic compounds as an alternative therapeutic approach in cancer is highlighted.
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Recycling of modified H2A-H2B provides short-term memory of chromatin states
Valentin Flury,Nazaret Reverón-Gómez,Nicolas Alcaraz,Kathleen R. Stewart-Morgan,Alice Wenger,Robert J. Klose,Anja Groth +6 more
TL;DR: In this paper , the authors measured H2A-H2B modifications during DNA replication and across the cell cycle using quantitative genomics and found that the histone H3-H4 modification landscape is restored by parental histone recycling and modification of new histones.
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Systematic Epigenome Editing Captures the Context-dependent Instructive Function of Chromatin Modifications
TL;DR: A modular epigenome editing platform that programmes nine key chromatin modifications to precise loci in living cells is developed, and the causal principles of how chromatin modification(s) influence transcription are unveiled, and how quantitative responses are calibrated by contextual interactions are dissected.
Journal ArticleDOI
3D genome, on repeat: Higher-order folding principles of the heterochromatinized repetitive genome
TL;DR: In this article , higher-order folding mechanisms of compartmentalization and loop extrusion and how they shape, and are shaped by, heterochromatin are discussed and compared using primarily mammalian model systems.
References
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The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
Erez Lieberman Aiden,Nynke L. van Berkum,Louise Williams,Maxim Imakaev,Tobias Ragoczy,Tobias Ragoczy,Agnes Telling,Agnes Telling,Ido Amit,Bryan R. Lajoie,Peter J. Sabo,Michael O. Dorschner,Richard Sandstrom,Bradley E. Bernstein,Bradley E. Bernstein,Michaël Bender,Mark Groudine,Mark Groudine,Andreas Gnirke,John A. Stamatoyannopoulos,Leonid A. Mirny,Eric S. Lander,Eric S. Lander,Job Dekker +23 more
TL;DR: Hi-C is described, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing and demonstrates the power of Hi-C to map the dynamic conformations of entire genomes.
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High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
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Topological domains in mammalian genomes identified by analysis of chromatin interactions
Jesse R. Dixon,Siddarth Selvaraj,Siddarth Selvaraj,Feng Yue,Audrey Kim,Yan-Yan Li,Yin-Zhong Shen,Ming Hu,Jun Liu,Bing Ren,Bing Ren +10 more
TL;DR: It is found that the boundaries of topological domains are enriched for the insulator binding protein CTCF, housekeeping genes, transfer RNAs and short interspersed element (SINE) retrotransposons, indicating that these factors may have a role in establishing the topological domain structure of the genome.
Journal ArticleDOI
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
TL;DR: In this paper, a histone H2AX species that has been phosphorylated specifically at serine 139 was found to be a major component of DNA double-stranded break.