HIV treatment as prevention: the key to an AIDS-free generation.
Mark Hull,Julio S. G. Montaner +1 more
TLDR
Results of a randomized clinical trial have now confirmed that antiretroviral therapy markedly decreases HIV transmission risk, and Mathematical models and population-based ecologic studies suggest that further expansion of antireTroviral coverage within current guidelines can play a major role in controlling the spread of HIV.About:
This article is published in Journal of Food and Drug Analysis.The article was published on 2013-12-01 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Treatment as prevention & Acquired immunodeficiency syndrome (AIDS).read more
Citations
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HIV pre-exposure prophylaxis (PrEP): a review of current knowledge of oral systemic HIV PrEP in humans
Christoph D. Spinner,Christoph Boesecke,Alexander Zink,Heiko Jessen,Hans-Jürgen Stellbrink,Jürgen K. Rockstroh,Stefan Esser +6 more
TL;DR: Continuous and intermittent PrEP demonstrated high efficacy in preventing HIV seroconversion, notably among MSM and the PrEP was well tolerated, and the evolution of HIV resistance has been low.
Journal ArticleDOI
A network intervention that locates and intervenes with recently HIV-infected persons: The Transmission Reduction Intervention Project (TRIP).
Georgios K. Nikolopoulos,Georgios K. Nikolopoulos,Eirini Pavlitina,Stephen Q. Muth,John A. Schneider,Mina Psichogiou,Leslie D. Williams,Dimitrios Paraskevis,Vana Sypsa,Gkikas Magiorkinis,Gkikas Magiorkinis,Pavlo Smyrnov,Anya Korobchuk,Tetyana I. Vasylyeva,Britt Skaathun,Melpomeni Malliori,E. Kafetzopoulos,Angelos Hatzakis,Samuel R. Friedman +18 more
TL;DR: Strategic network tracing that starts with recently infected persons could support public health efforts to find and treat people early in their HIV infection.
Journal ArticleDOI
The impact of COVID-19 on HIV financing in Nigeria: a call for proactive measures.
TL;DR: The relatively low number of cases and deaths compared with countries with similar populations in Africa may be due to limited test kits and laboratories, under-reporting and public health control measures.
Journal ArticleDOI
Challenges and emerging opportunities for the HIV prevention, treatment and care cascade in men who have sex with men in Asia Pacific.
Frits van Griensven,Thomas E. Guadamuz,Jan van Wijngaarden,Nittaya Phanuphak,Sunil S. Solomon,Ying Ru Lo +5 more
TL;DR: Widening the cascade with a preventive extension, including pre-exposure prophylaxis, the first proven efficacious and only biomedical HIV prevention strategy in MSM, will be instrumental in achieving HIV epidemic control in this group.
Journal ArticleDOI
Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.
Vikram Mehraj,Joseph Cox,Joseph Cox,Bertrand Lebouché,Bertrand Lebouché,Cecilia T. Costiniuk,Wei Cao,Wei Cao,Taisheng Li,Rosalie Ponte,Réjean Thomas,Jason Szabo,Jean-Guy Baril,Benoit Trottier,Pierre Côté,Roger LeBlanc,Julie Bruneau,Cécile Tremblay,Jean-Pierre Routy +18 more
TL;DR: The influence of socio‐demographic and clinical factors in addition to time trends on early ART initiation among participants of the Montreal Primary HIV Infection Study are investigated.
References
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Journal ArticleDOI
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
Frank J. Palella,Kathleen M. Delaney,Anne C. Moorman,Mark O. Loveless,Jack Fuhrer,Glen A. Satten,Diane J. Aschman,Scott D. Holmberg +7 more
TL;DR: The recent declines in morbidity and mortality due to AIDS are attributable to the use of more intensive antiretroviral therapies.
Journal ArticleDOI
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
TL;DR: In this article, Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.
Journal ArticleDOI
Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection
TL;DR: A study was conducted to evaluate the impact of protease inhibitors on the rates of selected opportunistic processes and mortality in patients with AIDS and found similar results.
Journal ArticleDOI
Prevention of HIV-1 infection with early antiretroviral therapy
TL;DR: The exciting evidence generated by this paper – that antiretroviral treatment of HIV-1 infection definitively reduces the risk of onward transmission of the virus by 96% – was rightly dubbed Science magazine's ‘Breakthrough of the Year’ in 2011.
Journal ArticleDOI
Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
Robert M. Grant,Javier R. Lama,Peter L. Anderson,Vanessa McMahan,Albert Y. Liu,Lorena Vargas,Pedro Goicochea,Martin Casapia,Juan Vicente Guanira-Carranza,Maria Esther Ramirez-Cardich,Orlando Montoya-Herrera,Telmo Fernandez,Valdilea G. Veloso,Susan Buchbinder,Suwat Chariyalertsak,Mauro Schechter,Linda-Gail Bekker,Kenneth H. Mayer,Esper G. Kallas,K. Rivet Amico,Kathleen Mulligan,Lane R. Bushman,Robert J. Hance,Carmela Ganoza,Patricia Defechereux,Brian S. Postle,Furong Wang,J. Jeff McConnell,Jia-Hua Zheng,Jeanny Lee,James F. Rooney,Howard S. Jaffe,Ana Martinez,David N. Burns,David V. Glidden +34 more
TL;DR: Oral FTC-TDF provided protection against the acquisition of HIV infection among the subjects and Detectable blood levels strongly correlated with the prophylactic effect.
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Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more