Journal ArticleDOI
Human β1- and β2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes
TLDR
The β 1 and β 2 -adrenergic receptor subtypes are biochemically and functionally similar and mediate the catecholamine-induced activation of adenylyl cyclase through the GTP-binding protein G s.About:
This article is published in Trends in Neurosciences.The article was published on 1988-01-01. It has received 38 citations till now. The article focuses on the topics: Class C GPCR & Rhodopsin-like receptors.read more
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Molecular characterization of a functional cDNA for rat substance P receptor.
Yasunori Yokota,Yoshiki Sasai,Kohichi Tanaka,Takeshi Fujiwara,Kunihiro Tsuchida,Ryuichi Shigemoto,Akira Kakizuka,Hiroaki Ohkubo,S Nakanishi +8 more
TL;DR: The observed sequence similarity and divergence would contribute to the expression of similar but pharmacologically distinguishable activities of the two tachykinin receptors.
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Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.
TL;DR: A higher level of ligand texture is demonstrated than previously anticipated, opening perspectives for the establishment of pluridimensional correlations between signaling profiles, drug classification, therapeutic efficacy, and safety.
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Is there a third heart β-adrenoceptor?
TL;DR: Alberto Kaumann suggests that such non-conventional partial agonists, often analogues of pindolol, may act through a third heart β 2 -adrenoceptor, which resembles the β 3 -ad Renoceptor of white adipocytes and smooth muscle of airways and ileum.
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In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical β-adrenoceptors in rat colon
TL;DR: The results indicate that the PEAT are a new class of β‐adrenoceptor agonists and suggest that their preferential intestinal action may be accounted for by selectivity for atypical β‐ adrenoceptors, abundant in the rat colon and distinct from the currently recognized β1 and β2 subtypes.
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Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.
Yuting Tang,Liaoyuan A. Hu,William E. Miller,Niels Ringstad,Randy A. Hall,Julie A. Pitcher,Pietro DeCamilli,Robert J. Lefkowitz +7 more
TL;DR: The studies demonstrate a role of the SH3p4/p8/p13 protein family in beta1-AR signaling and suggest that interaction between proline-rich motifs and SH3-containing proteins may represent a previously underappreciated aspect of G-protein coupled receptor signaling.
References
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Journal ArticleDOI
G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
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Three-dimensional model of purple membrane obtained by electron microscopy
Richard Henderson,P. N. T. Unwin +1 more
TL;DR: A 7-Å resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens and shows that Lipid bilayer regions fill the spaces between the protein molecules.
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Differentiation of receptor systems activated by sympathomimetic amines.
TL;DR: The classification of receptor systems which are activated by sympathomimetic amines has engaged the attention of many investigators as mentioned in this paper, who have suggested the convenient designations of alpha (α) and beta (β) to distinguish major differences in the responses elicited in various organ systems.
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Molecular genetics of human color vision: the genes encoding blue, green, and red pigments
TL;DR: The isolation and sequencing of genomic and complementary DNA clones that encode the apoproteins of these three pigments are described and the deduced amino acid sequences show 41 +/- 1 percent identity with rhodopsin.
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Identification of a family of muscarinic acetylcholine receptor genes
TL;DR: Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence.