Journal ArticleDOI
Hypothalamic paraventricular nucleus: interaction between α2-noradrenergic system and circulating hormones and nutrients in relation to energy balance
TLDR
Evidence has led to the hypothesis that NE in the PVN, through the activation of glucocorticoid- and glucose-sensitive alpha 2-receptor sites, is physiologically active in energy homeostasis, most particularly at the onset of the animal's active cycle.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1988-06-01. It has received 220 citations till now. The article focuses on the topics: Energy homeostasis & Hypothalamus.read more
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Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
TL;DR: The current knowledge concerning the multiple actions of PACAP in the central nervous system and in various peripheral organs including the endocrine glands, the airways, and the cardiovascular and immune systems are reviewed, as well as the different effects ofPACAP on a number of tumor cell types.
Journal ArticleDOI
Catecholamine modulation of prefrontal cortical cognitive function.
TL;DR: A fresh understanding of the neurochemical influences on PFC function has led to new treatments for cognitive disorders such as Attention Deficit Hyperactivity Disorder (ADHD), and may help to elucidate the prevalence of PFC dysfunction in other mental disorders.
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Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice
TL;DR: The results indicate the existence of a functional synergistic interaction between leptin and CCK leading to early suppression of food intake which involves CCK-A receptors and capsaicin-sensitive afferent fibers.
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Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight.
Denis G. Baskin,Dianne Figlewicz Lattemann,Randy J. Seeley,Stephen C. Woods,Daniel Porte,Michael W. Schwartz +5 more
TL;DR: Research showing that leptin and insulin enhance the satiety action of peripheral CCK, thereby causing meals to be terminated earlier and reducing cumulative food intake, suggests that hypothalamic pathways that are sensitive toptin and insulin adiposity signals have anatomical connections with caudal brainstem neurons that respond to meal-related signals and regulate meal size.
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Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study
TL;DR: The results suggest that the PVH plays a critical role in the modulation of ACTH and beta-endorphin release from the pituitary, and that CRF-containing pathways in the brain are involved in the mediation of autonomic responses.
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Hypothalamic Integration: Organization of the Paraventricular and Supraoptic Nuclei
Journal Article
Presynaptic regulation of the release of catecholamines.
TL;DR: Evidence has accumulated in favour of the view that, in addition to the classical postsynaptic adrenoceptors that mediate the responses of the effector organ, there are also receptors located on the noradrenergic nerve terminals that appear to be involved in the modulation of the release of dopamine and of epinephrine in the central nervous system.
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Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor.
TL;DR: Aided by decades of expertise accumulated in laboratories throughout the world, workers finally having the right stuff at hand rapidly established CRF-41 as a major physiological mediator of the hypothalamic control of ACTH secretion.
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Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor.
Kjell Fuxe,Ann-Charlotte Wikström,Sam Okret,Luigi F. Agnati,Anders Härfstrand,Zhao-Ying Yu,Lars Granholm,Michaeli Zoli,Wylie Vale,Jan-Åke Gustafsson +9 more
TL;DR: It is suggested that the hypothalamic GR may be involved in the regulation of especially CRF secretion but also in the secretion of other anterior pituitary hormones such as TRH and somatostatin.