Hypothermic liquid ventilation prevents early hemodynamic dysfunction and cardiovascular mortality after coronary artery occlusion complicated by cardiac arrest in rabbits.
Lys Darbera,Mourad Chenoune,Fanny Lidouren,Matthias Kohlhauer,Clovis Adam,Patrick Bruneval,Bijan Ghaleh,Jean-Luc Dubois-Randé,Pierre Carli,Benoît Vivien,Jean-Damien Ricard,Alain Berdeaux,Renaud Tissier +12 more
TLDR
Achieving hypothermia rapidly is critical to improve the cardiovascular outcome after cardiac arrest with underlying myocardial infarction.Abstract:
OBJECTIVES: Ultrafast and whole-body cooling can be induced by total liquid ventilation with temperature-controlled perfluorocarbons. Our goal was to determine whether this can afford maximal cardio- and neuroprotections through cooling rapidity when coronary occlusion is complicated by cardiac arrest. DESIGN: Prospective, randomized animal study. SETTING: Academic research laboratory. SUBJECTS: Male New Zealand rabbits. INTERVENTIONS: Chronically instrumented rabbits were submitted to coronary artery occlusion and ventricular fibrillation. After 8 minutes of cardiac arrest, animals were resuscitated and submitted to a normothermic follow-up (control group) or to 3 hours of mild hypothermia induced by total liquid ventilation (total liquid ventilation group) or by combination of cold saline infusion and cold blankets application (saline group). Coronary reperfusion was permitted 40 minutes after the onset of occlusion. After awakening, rabbits were followed up during 7 days. MEASUREMENTS AND MAIN RESULTS: Ten animals were resuscitated in each group. In the control group, all animals secondarily died of cardiac/respiratory failure (8 of 10) or neurological dysfunction (2 of 10). In the saline group, the target temperature of 32°C was achieved within 30-45 minutes after cooling initiation. This slightly reduced infarct size versus control (41% ± 16% vs 54% ± 8% of risk zone, respectively; p < 0.05) but failed to significantly improve cardiac output, neurological recovery, and survival rate (three survivors, six death from cardiac/respiratory failure, and one from neurological dysfunction). Conversely, the 32°C temperature was achieved within 5-10 minutes in the total liquid ventilation group. This led to a dramatic reduction in infarct size (13% ± 4%; p < 0.05 vs other groups) and improvements in cardiac output, neurological recovery, and survival (eight survivors, two deaths from cardiac/respiratory failure). CONCLUSIONS: Achieving hypothermia rapidly is critical to improve the cardiovascular outcome after cardiac arrest with underlying myocardial infarction.read more
Citations
More filters
Journal ArticleDOI
Impact of intra-arrest therapeutic hypothermia in outcomes of prehospital cardiac arrest: a randomized controlled trial
Guillaume Debaty,Maxime Maignan,Dominique Savary,François Xavier Koch,Stéphane Ruckly,Michel Durand,Julien Picard,Christophe Escallier,Renaud Chouquer,Charles Santre,Clémence Minet,Dorra Guergour,Laure Hammer,Hélène Bouvaist,Loic Belle,Christophe Adrie,Jean François Payen,Françoise Carpentier,Pierre Yves Gueugniaud,Vincent Danel,Jean-François Timsit +20 more
TL;DR: IATH did not affect biological markers of inflammation or brain damage or clinical outcome after out-of-hospital cardiac arrest and no difference in survival and cerebral performance were found at 1 month.
Journal ArticleDOI
Hypothermic Total Liquid Ventilation Is Highly Protective Through Cerebral Hemodynamic Preservation and Sepsis-Like Mitigation After Asphyxial Cardiac Arrest.
Matthias Kohlhauer,Fanny Lidouren,Isabelle Remy-Jouet,Nicolas Mongardon,Clovis Adam,Patrick Bruneval,Hakim Hocini,Yves Levy,Fabiola Blengio,Pierre Carli,Benoît Vivien,Jean-Damien Ricard,Philippe Micheau,Hervé Walti,Mathieu Nadeau,Raymond Robert,Vincent Richard,Paul Mulder,David Maresca,Charlie Demene,Mathieu Pernot,Mickael Tanter,Bijan Ghaleh,Alain Berdeaux,Renaud Tissier +24 more
TL;DR: Ultrafast cooling by total liquid ventilation limits the post–cardiac arrest syndrome after asphyxial cardiac arrest in rabbits, and involves an early limitation in reactive oxidative species production, blood-brain barrier disruption, and delayed preservation against the systemic inflammatory response.
Journal ArticleDOI
Kidney Protection by Hypothermic Total Liquid Ventilation after Cardiac Arrest in Rabbits
Renaud Tissier,Sébastien Giraud,Nathalie Quellard,Béatrice Fernandez,Fanny Lidouren,Lys Darbera,Matthias Kohlhauer,Sandrine Pons,Mourad Chenoune,Patrick Bruneval,Jean-Michel Goujon,Bijan Ghaleh,Alain Berdeaux,Thierry Hauet +13 more
TL;DR: Ultrafast cooling with TLV is renal protective after cardiac arrest and resuscitation, which could increase kidney availability for organ donation.
Journal ArticleDOI
Therapeutic hypothermia to protect the heart against acute myocardial infarction.
Matthias Kohlhauer,Alain Berdeaux,Alain Berdeaux,Alain Berdeaux,Bijan Ghaleh,Bijan Ghaleh,Bijan Ghaleh,Renaud Tissier,Renaud Tissier,Renaud Tissier +9 more
TL;DR: Novel strategies for ultra-fast induction of hypothermia and/or prehospital cooling might therefore be more beneficial in patients with a large infarction and more rapid cooling before reperfusion.
Journal ArticleDOI
Total liquid ventilation offers ultra-fast and whole-body cooling in large animals in physiological conditions and during cardiac arrest
Alice Hutin,Fanny Lidouren,Fanny Lidouren,Fanny Lidouren,Matthias Kohlhauer,Matthias Kohlhauer,Matthias Kohlhauer,Luc Lotteau,Aurélien Seemann,Aurélien Seemann,Aurélien Seemann,Nicolas Mongardon,Nicolas Mongardon,Nicolas Mongardon,Bertrand Renaud,Daniel Isabey,Daniel Isabey,Pierre Carli,Benoît Vivien,Jean-Damien Ricard,Thierry Hauet,Richard E. Kerber,Alain Berdeaux,Alain Berdeaux,Alain Berdeaux,Bijan Ghaleh,Bijan Ghaleh,Bijan Ghaleh,Renaud Tissier,Renaud Tissier,Renaud Tissier +30 more
TL;DR: Using a specifically designed liquid ventilator, TLV induced a very rapid cooling of the entire body in large animals and could be relevant for ultra-rapid cooling independently of body weight.
References
More filters
Journal ArticleDOI
Part 9: Post-Cardiac Arrest Care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Mary Ann Peberdy,Clifton W. Callaway,Robert W. Neumar,Romergryko G. Geocadin,Janice L. Zimmerman,Michael W. Donnino,Andrea Gabrielli,Scott M. Silvers,Arno Zaritsky,Raina M. Merchant,Terry L. Vanden Hoek,Steven L. Kronick +11 more
TL;DR: The goal of immediate post-cardiac arrest care is to optimize systemic perfusion, restore metabolic homeostasis, and support organ system function to increase the likelihood of intact neurological survival.
Journal ArticleDOI
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok Junhee Seok,Shaw Warren,G. Cuenca Alex,N. Mindrinos Michael,V. Baker Henry,Weihong Xu,Daniel R. Richards,Grace P. McDonald-Smith,Hong Gao,Laura Hennessy,Celeste C. Finnerty,Cecilia M Lopez,Shari Honari,Ernest E. Moore,Joseph P. Minei,Joseph Cuschieri,Paul E. Bankey,Jeffrey L. Johnson,Jason L. Sperry,Avery B. Nathens,Timothy R. Billiar,Michael West,Marc G. Jeschke,Matthew B. Klein,Richard L. Gamelli,Nicole S. Gibran,Bernard H. Brownstein,Carol L. Miller-Graziano,Steve E. Calvano,Philip H. Mason,J. Perren Cobb,Laurence G. Rahme,Stephen F. Lowry,Ronald V. Maier,Lyle L. Moldawer,David N. Herndon,Ronald W. Davis,Wenzhong Xiao,Wenzhong Xiao,Ronald G. Tompkins +39 more
TL;DR: This study shows that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.
Journal ArticleDOI
Part 12: Cardiac Arrest in Special Situations 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Terry L. Vanden Hoek,Laurie J. Morrison,Michael Shuster,Michael W. Donnino,Elizabeth Sinz,Eric J. Lavonas,Farida M. Jeejeebhoy,Andrea Gabrielli +7 more
TL;DR: This section of the 2010 AHA Guidelines for CPR and ECC addresses cardiac arrest in situations that require special treatments or procedures beyond those provided during basic life support (BLS) and advanced cardiovascular life support(ACLS).
Journal ArticleDOI
Immediate Coronary Angiography in Survivors of Out-of-Hospital Cardiac Arrest
Christian Spaulding,Luc-Marie Joly,Alain Rosenberg,Mehran Monchi,Simon Weber,Jean-François Dhainaut,Pierre Carli +6 more
TL;DR: Acute coronary-artery occlusion is frequent in survivors of out-of-hospital cardiac arrest and is predicted poorly by clinical and electrocardiographic findings, but accurate diagnosis by immediate coronary angiography can be followed in suitable candidates by coronary angioplasty, which seems to improve survival.
Journal ArticleDOI
Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: a prospective, randomized study
TL;DR: Mild, resuscitative cerebral hypothermia induced immediately with reperfusions after cardiac arrest improves cerebral functional and morphologic outcome, whereas a delay of 15 mins in initiation of cooling after reperfusion may not improve functional outcome, although it may slightly decrease tissue damage.
Related Papers (5)
Rapid cooling preserves the ischaemic myocardium against mitochondrial damage and left ventricular dysfunction
Renaud Tissier,N. Couvreur,N. Couvreur,N. Couvreur,Bijan Ghaleh,Bijan Ghaleh,Bijan Ghaleh,Patrick Bruneval,Fanny Lidouren,Fanny Lidouren,Fanny Lidouren,Didier Morin,Didier Morin,Didier Morin,Roland Zini,Roland Zini,Roland Zini,Alain Bizé,Alain Bizé,Alain Bizé,Mourad Chenoune,Mourad Chenoune,Mourad Chenoune,Marie-France Belair,Chantal Mandet,Martine Douheret,Jean-Luc Dubois-Randé,Jean-Luc Dubois-Randé,James C. Parker,Michael V. Cohen,James M. Downey,Alain Berdeaux,Alain Berdeaux,Alain Berdeaux +33 more