Hypoxia-Induced Angiogenesis Good and Evil
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TLDR
A thorough understanding of how hypoxia regulates angiogenesis through an ever-expanding number of pathways in multiple cell types will be essential for the identification of new therapeutic targets and modalities.Abstract:
The vascular network delivers oxygen (O(2)) and nutrients to all cells within the body. It is therefore not surprising that O(2) availability serves as a primary regulator of this complex organ. Most transcriptional responses to low O(2) are mediated by hypoxia-inducible factors (HIFs), highly conserved transcription factors that control the expression of numerous angiogenic, metabolic, and cell cycle genes. Accordingly, the HIF pathway is currently viewed as a master regulator of angiogenesis. HIF modulation could provide therapeutic benefit for a wide array of pathologies, including cancer, ischemic heart disease, peripheral artery disease, wound healing, and neovascular eye diseases. Hypoxia promotes vessel growth by upregulating multiple pro-angiogenic pathways that mediate key aspects of endothelial, stromal, and vascular support cell biology. Interestingly, recent studies show that hypoxia influences additional aspects of angiogenesis, including vessel patterning, maturation, and function. Through extensive research, the integral role of hypoxia and HIF signaling in human disease is becoming increasingly clear. Consequently, a thorough understanding of how hypoxia regulates angiogenesis through an ever-expanding number of pathways in multiple cell types will be essential for the identification of new therapeutic targets and modalities.read more
Citations
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The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy.
TL;DR: Better understanding of the role of hypoxia in cancer progression will open new windows for the discovery of new therapeutics targeting hypoxic tumor cells and hypoxic microenvironment.
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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
TL;DR: Results from clinical studies of a number of HIF prolyl hydroxylase inhibitors are increasingly available and provide support for the continued evaluation of the risk-benefit ratio of this novel therapeutic approach to the treatment of anemia in CKD.
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Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves
Anne-Laure Cattin,Jemima J. Burden,Lucie Van Emmenis,Francesca E. Mackenzie,Julian J.A. Hoving,Noelia Garcia Calavia,Yan-Ping Guo,Maeve McLaughlin,Laura H. Rosenberg,Victor Quereda,Denisa Jamecna,Ilaria Napoli,Simona Parrinello,Tariq Enver,Christiana Ruhrberg,Alison C. Lloyd +15 more
TL;DR: It is shown that blood vessels direct the migrating cords of Schwann cells, which use the blood vessels as "tracks" to cross a ‘bridge’ of new tissue, which forms to reconnect a severed nerve.
Journal ArticleDOI
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond.
TL;DR: Understanding these processes could shed light on pathologies associated with hypoxia, including cardiovascular diseases and cancer, and disease mechanisms, such as inflammation and wound repair.
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Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
TL;DR: Judicious dosing of anti-angiogenic treatment can transiently normalize the tumor vasculature by decreasing vascular permeability and improving tumor perfusion and blood flow, and synergize with immunotherapy in this time window.
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