Identification of linear epitopes in bacillus anthracis protective antigen bound by neutralizing antibodies
Nareen Abboud,Magdia De Jesus,Antonio Nakouzi,Radames J. B. Cordero,Mario Pujato,Andras Fiser,Johanna Rivera,Arturo Casadevall +7 more
TLDR
These results identify the first linear neutralizing epitopes of PA and show that peptides containing epitope sequences can elicit neutralizing antibody responses, a finding that could be exploited for vaccine design.About:
This article is published in Journal of Biological Chemistry.The article was published on 2009-09-11 and is currently open access. It has received 45 citations till now. The article focuses on the topics: Epitope mapping & Epitope.read more
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Patent
Anti-pd-l1 antibodies and uses thereof
Nastri Horacio G,Christel Iffland,Olivier Leger,An Qi,Mark Cartwright,Mckenna Sean D,Vanita D. Sood,Hao Gang +7 more
TL;DR: In this paper, anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity.
Journal ArticleDOI
Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins
Johanna Rivera,Radames J. B. Cordero,Antonio Nakouzi,Susana Frases,André Moraes Nicola,André Moraes Nicola,Arturo Casadevall +6 more
TL;DR: The results indicate that toxin secretion in B. anthracis is, at least, partially vesicle-associated, thus allowing concentrated delivery of toxin components to target host cells, a mechanism that may increase toxin potency.
Book ChapterDOI
Comparative Protein Structure Modelling
TL;DR: The current state and recent advances in structure modelling approaches are reviewed here, with special emphasis on comparative structure modelling techniques.
Journal ArticleDOI
A requirement for FcγR in antibody-mediated bacterial toxin neutralization
Nareen Abboud,Siu Kei Chow,Carolyn Saylor,Alena Janda,Jeffery V. Ravetch,Matthew D. Scharff,Arturo Casadevall +6 more
TL;DR: Constant regions of antibodies influence toxin neutralization in a manner dependent on FcγR.
Book ChapterDOI
Immunity to Ricin: Fundamental Insights into Toxin–Antibody Interactions
Joanne M. O’Hara,Anastasiya Yermakova,Anastasiya Yermakova,Nicholas J. Mantis,Nicholas J. Mantis +4 more
TL;DR: The characterization of dozens of monoclonal antibodies against the toxin's enzymatic and binding subunits has begun to reveal fundamental insights into the underlying mechanisms by which antibodies neutralize (or fail to neutralize) ricin in systemic and mucosal compartments.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Comparative Protein Modelling by Satisfaction of Spatial Restraints
Andrej Sali,Tom L. Blundell +1 more
TL;DR: A comparative protein modelling method designed to find the most probable structure for a sequence given its alignment with related structures, which is automated and illustrated by the modelling of trypsin from two other serine proteinases.
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Production of monoclonal antibodies: strategy and tactics.
TL;DR: A myeloma line has been developed which produces no globulin chains of its own, has a duplication of 8.7 h, fuses effectively with B-lymphoblasts and produces stable hybrids, and an enhancing effect of macrophages on hybridoma yields has been observed.
Journal ArticleDOI
Anthrax as a biological weapon, 2002: updated recommendations for management.
Thomas V. Inglesby,Tara O'Toole,Donald A. Henderson,John G. Bartlett,Michael S. Ascher,Edward M. Eitzen,Arthur M. Friedlander,Julie L. Gerberding,Jerome Hauer,James M. Hughes,Joseph E. McDade,Michael T. Osterholm,Gerald W. Parker,Trish M. Perl,Philip K. Russell,Kevin Tonat +15 more
TL;DR: This revised consensus statement presents new information based on the analysis of the anthrax attacks of 2001, including developments in the investigation of the Anthrax Attacks of 2001; important symptoms, signs, and laboratory studies; new diagnostic clues that may help future recognition of this disease; updated antibiotic therapeutic considerations; and judgments about environmental surveillance and decontamination.
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