Immunity against HIV/AIDS, malaria, and tuberculosis during co-infections with neglected infectious diseases: recommendations for the European Union research priorities.
Diana Boraschi,Markos Abebe Alemayehu,Abraham Aseffa,Francesca Chiodi,John Chisi,Gianfranco Del Prete,T. Mark Doherty,Ibrahim M. Elhassan,Howard Engers,Ben Gyan,Ali M. Harandi,Thomas Kariuki,Fred Kironde,Bourema Kouriba,Jean Langhorne,Tamás Laskay,Donata Medaglini,Ole F. Olesen,Philip Onyebujoh,Carla Palma,Robert W. Sauerwein,Elopy Sibanda,Ulrich Steinhoff,Aldo Tagliabue,Andreas Thiel,Mahnaz Vahedi,Marita Troye-Blomberg +26 more
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TLDR
The only possibility for winning the fight against infections in low-income countries is by studying, in the most global way possible, the complex interaction between different infections and conditions of malnourishment, the new scientific and technical tools of the post-genomic era.Abstract:
Immunity against HIV/AIDS, Malaria, and Tuberculosis during Co-Infections with Neglected Infectious Diseases : Recommendations for the European Union Research Priorities.read more
Citations
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The nature and consequences of coinfection in humans.
TL;DR: These results suggest differences between coinfected patients and those with single infections, with coinfection having serious health effects, and there is a pressing need to quantify the tendency towards negative effects.
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Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum
Linda J. Wammes,Firdaus Hamid,Aprilianto E. Wiria,Brechje de Gier,Erliyani Sartono,Rick M. Maizels,Adrian J. F. Luty,Yvonne Fillie,Gary T. Brice,Taniawati Supali,Hermelijn H. Smits,Maria Yazdanbakhsh +11 more
TL;DR: It is demonstrated that geohelminth‐associated Treg influence immune responses to bystander Ag of mycobacteria and plasmodia and may have important consequences for co‐endemic infections and vaccine trials.
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Polyparasitism Is Associated with Increased Disease Severity in Toxoplasma gondii-Infected Marine Sentinel Species
Amanda K. Gibson,Stephen Raverty,Dyanna M. Lambourn,Jessica L. Huggins,Spencer L. Magargal,Michael E. Grigg +5 more
TL;DR: The finding of widespread polyparasitism among marine mammals indicates pervasive contamination of waterways by zoonotic agents, and the significant association of concomitant infection with mortality and protozoal encephalitis identifies polyParasitism as an important factor contributing to disease severity in marine mammals.
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Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)
Aprilianto E. Wiria,Aprilianto E. Wiria,Margaretta A. Prasetyani,Firdaus Hamid,Firdaus Hamid,Linda J. Wammes,Bertrand Lell,Iwan Ariawan,Hae-Won Uh,Heri Wibowo,Yenny Djuardi,Sitti Wahyuni,Inge Sutanto,Linda May,Adrian J. F. Luty,Jaco J. Verweij,Erliyani Sartono,Maria Yazdanbakhsh,Taniawati Supali +18 more
TL;DR: The area of Nangapanda on Flores Island, Indonesia, where malaria and helminth parasites are co-endemic was selected for a longitudinal study, and a Double-blind randomized trial will be performed, incorporating repeated treatment with albendazole (400 mg) or placebo at three monthly intervals.
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Analysis of a summary network of co-infection in humans reveals that parasites interact most via shared resources.
TL;DR: This work used data from over 300 published studies to construct a network that offers the first broad indications of how groups of co-infecting parasites tend to interact, and found pairs of parasite species had most potential to interact indirectly through shared resources, rather than through immune responses or other parasites.
References
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Control of Neglected Tropical Diseases
Peter J. Hotez,David H. Molyneux,Alan Fenwick,Jacob Kumaresan,Sonia Ehrlich Sachs,Jeffrey D. Sachs,Lorenzo Savioli +6 more
TL;DR: In addition to malaria, tuberculosis, and human immunodeficiency virus infection, several other infectious diseases are associated with substantial morbidity and mortality as discussed by the authors, in particular 13 tropical diseases that cause disabilities such as blindness and heart failure.
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Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria
Peter J. Hotez,David H. Molyneux,Alan Fenwick,Eric A. Ottesen,Sonia Ehrlich Sachs,Jeffrey D. Sachs +5 more
TL;DR: It is argued that achieving success in the global fight against HIV/AIDS, tuberculosis, and malaria may well require a concurrent attack on the neglected tropical diseases.
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Clare Huppatz,David N Durrheim +1 more
TL;DR: From the Sabin Vaccine Institute, and George Washington University, Washington, DC (P.J.H.Hotez, M.E.S., J.D.S.), this work was funded by the National Institutes of Health.
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"Rapid-impact interventions": how a policy of integrated control for Africa's neglected tropical diseases could benefit the poor.
TL;DR: Controlling seven tropical infections in Africa would cost just 40 cents per person per year, and would permanently benefit hundreds of millions of people.
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