Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial hypercholesterolemia
Alexina Orsoni,Alexina Orsoni,Alexina Orsoni,Elise F. Villard,Elise F. Villard,Elise F. Villard,Eric Bruckert,Paul Robillard,Paul Robillard,Paul Robillard,Alain Carrié,Dominique Bonnefont-Rousselot,M. John Chapman,M. John Chapman,M. John Chapman,Geesje M. Dallinga-Thie,Wilfried Le Goff,Wilfried Le Goff,Wilfried Le Goff,Maryse Guerin,Maryse Guerin,Maryse Guerin +21 more
TLDR
It is demonstrated that rapid removal of circulating lipoprotein particles by LDL apheresis transitorily reduces RCT and is without impact on the intrinsic ability of HDL particles to promote either cellular free cholesterol efflux from macrophages or to deliver CE to hepatic cells.About:
This article is published in Journal of Lipid Research.The article was published on 2012-04-01 and is currently open access. It has received 23 citations till now. The article focuses on the topics: LDL apheresis & Familial hypercholesterolemia.read more
Citations
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Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil
TL;DR: This work obtained the first de novo transcriptome of mahi-mahi, and confirmed the novel approach effective for exploring tox-pathways in non-model species, and identified a list of co-expressed genes as potential biomarkers which will provide information for the construction of an Adverse Outcome Pathway which could be useful in Ecological Risk Assessments.
Journal ArticleDOI
Modulating cholesterol efflux capacity to improve cardiovascular disease.
Nicholas Brownell,Anand Rohatgi +1 more
TL;DR: Altering cholesterol efflux capacity (CEC) could be a novel therapeutic approach to improving cardiovascular risk profiles and evaluate CEC modulation by commonly used medications.
Journal Article
ABCA1 : The gatekeeper for eliminating excess tissue cholesterol
TL;DR: As the primary gatekeeper for eliminating tissue cholesterol, ABCA1 has a major impact on cellular and whole body cholesterol metabolism and is likely to play an important role in protecting against cardiovascular disease.
Journal ArticleDOI
The extended abnormalities in lipoprotein metabolism in familial hypercholesterolemia: developing a new framework for future therapies.
TL;DR: Knowledge of an extended metabolic framework will provide the basis for judiciously selecting new pharmacotherapies to treat FH, including apoB antisense oligonucleotides, microsomal transfer protein (MTP) inhibitors and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors.
Journal ArticleDOI
Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia
Katherine D. Connolly,Gareth R. Willis,Dev Datta,Elizabeth A Ellins,Elizabeth A Ellins,Kristin Ladell,David Price,Irina A. Guschina,D. Aled Rees,Philip E. James +9 more
TL;DR: Apheresis nonselectively removes annexin V-positive platelet-derived MPs in individuals with FH; these MPs are potent inducers of coagulation and are elevated in CVD; this reduction in pathological MPs could relate to the long-term benefits of apheresis.
References
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Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Scott M. Grundy,James I. Cleeman,C. Noel Bairey Merz,H. Bryan Brewer,Luther T. Clark,Donald B. Hunninghake,Richard C. Pasternak,Sidney C. Smith,Neil J. Stone +8 more
TL;DR: The trials confirm the benefit of cholesterol-lowering therapy in high-risk patients and support the ATP III treatment goal of low-density lipoprotein cholesterol (LDL-C) <100 mg/dL, and confirm that older persons benefit from therapeutic lowering of LDL-C.
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High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.
David Gordon,Jeffrey L. Probstfield,Robert J. Garrison,James D. Neaton,William P. Castelli,J. D. Knoke,David R. Jacobs,Shrikant I. Bangdiwala,H. A. Tyroler +8 more
TL;DR: A consistent inverse relation of high-density lipoprotein cholesterol levels and coronary heart disease event rates was apparent in BRHS as well as in the four American studies.
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ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins
TL;DR: ABCG1 is highly expressed in macrophages and probably mediates cholesterol efflux from macrophage foam cells to the major HDL fractions, providing a mechanism to explain the relationship between HDL levels and atherosclerosis risk.
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High Density Lipoproteins and Arteriosclerosis: Role of Cholesterol Efflux and Reverse Cholesterol Transport
TL;DR: High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease, and HDL exerts various potentially antiatherogenic properties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs.
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A density gradient ultracentrifugal procedure for the isolation of the major lipoprotein classes from human serum.
TL;DR: Fractionation of gradients on the basis of band distribution, followed by chemical, physical, and immunological analyses of the four principal fractions provided data on their electrophoretic mobility, chemical composition, morphology and size distribution, immunological reactivity and apolipoprotein content, thereby confirming their identities as VLDL, LDL, HDL2, and HDL3.