Journal ArticleDOI
Imparting Functionality to MOF Nanoparticles by External Surface Selective Covalent Attachment of Polymers
Andreas Zimpel,Tobias Preiß,Ruth Röder,Hanna Engelke,Michael Ingrisch,Michael Peller,Joachim O. Rädler,Ernst Wagner,Thomas Bein,Ulrich Lächelt,Stefan Wuttke +10 more
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TLDR
This work proves covalent nanoparticles-polymer bond formation by liquid NMR after dissolution of the functionalized MOF under mild conditions and estimates the amount of covalently attached polymer by UV–vis spectroscopy.Abstract:
Selective functionalization of the external surface of porous nanoparticles is of great interest for numerous potential applications in the field of nanotechnology. Regarding metal–organic frameworks (MOFs), few methods for such modifications have been reported in the literature. Herein, we focus on the covalent attachment of functional polymers on the external surface of MIL-100(Fe) nanoparticles in order to implement properties such as increased chemical and colloidal stability or dye-labeling for the investigation of the particles by fluorescence based techniques. We prove covalent nanoparticles-polymer bond formation by liquid NMR after dissolution of the functionalized MOF under mild conditions and estimate the amount of covalently attached polymer by UV–vis spectroscopy. The functionalization of the MOF nanoparticles with fluorescently labeled polymers enables the investigation of nanoparticle uptake into tumor cells by fluorescence microscopy. Furthermore, the influence of the polymer shell on the ...read more
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Chemodynamic Therapy: Tumour Microenvironment‑Mediated Fenton and Fenton‑like Reactions
TL;DR: Various strategies based on the Fenton reaction have been employed to enhance hydroxyl radical generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview.
Journal ArticleDOI
Hybridization of MOFs and polymers
TL;DR: This review article focuses on the methodology for hybridization of MOFs and polymers, as well as the intriguing functions of hybrid materials.
Journal ArticleDOI
Metal–Organic Framework Nanoparticles
Shunzhi Wang,C. Michael McGuirk,C. Michael McGuirk,Andrea I. d’Aquino,Jarad A. Mason,Chad A. Mirkin +5 more
TL;DR: Recent developments in the synthesis and postsynthetic surface functionalization of MOF NPs that strengthen the fundamental understanding of how such structures form and grow are highlighted; the internal structure and external surface properties of these novel nanomaterials are highlighted.
Journal ArticleDOI
Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine.
TL;DR: A global view of the studies that evaluated nano particles of metal‐organic frameworks' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation is provided.
Journal ArticleDOI
Metal-Organic Framework Nanoparticles in Photodynamic Therapy: Current Status and Perspectives
TL;DR: In this paper, the authors discuss the recent applications of metal-organic framework nanoparticles (MOF NPs) in photodynamic therapy (PDT) of cancer and highlight the potential synergistic effect that could result from their association.
References
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The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Journal ArticleDOI
Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging
Patricia Horcajada,Tamim Chalati,Christian Serre,Brigitte Gillet,Catherine Sebrié,Tarek Baati,Jarrod F. Eubank,Daniela Heurtaux,Pascal Clayette,Christine Kreuz,Jong-San Chang,Young Kyu Hwang,Véronique Marsaud,Phuong-Nhi Bories,Luc Cynober,Sophie Gil,Gérard Férey,Patrick Couvreur,Ruxandra Gref +18 more
TL;DR: It is shown that specific non-toxic porous iron(III)-based metal-organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs against cancer and AIDS.
Journal ArticleDOI
Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.
Journal ArticleDOI
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
TL;DR: These factors have been shown to substantially affect the biodistribution and blood circulation half-life of circulating nanoparticles by reducing the level of nonspecific uptake, delaying opsonization, and increasing the extent of tissue specific accumulation.
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