Journal ArticleDOI
Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor.
Young Hwan Ahn,Jean-Charles Bensadoun,Patrick Aebischer,Anne D. Zurn,Åke Seiger,Anders Björklund,Olle Lindvall,Lars Wahlberg,Patrik Brundin,Gabriele S. Kaminski Schierle +9 more
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TLDR
It is suggested that continuous and safe delivery of GDNF to the brain could be a potential way to optimize neural transplantation as a therapy for Parkinson's disease.About:
This article is published in Brain Research Bulletin.The article was published on 2005-07-30. It has received 38 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & Neurotrophic factors.read more
Citations
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Journal ArticleDOI
Advances in the treatment of Parkinson's disease.
TL;DR: The limitations of currently available therapies and the most recent research regarding neuroprotective agents, antioxidants, stem cell research, vaccines and various surgical techniques available and being developed for the management of PD are summarized.
Journal ArticleDOI
Emerging restorative treatments for Parkinson's disease.
TL;DR: Experimental and clinical data regarding growth factor administration and glial cell line-derived neurotrophic factor, particularly its role in neuroprotection and in regeneration in Parkinson's disease are described.
Journal ArticleDOI
Polymer hollow fiber three-dimensional matrices with controllable cavity and shell thickness
TL;DR: The development of a novel technology to fabricate hollow fibers with controllable hollow cavity diameter and shell thickness is reported here and applications in tissue engineering and controlled drug delivery of these constructs are presented.
Journal ArticleDOI
Encapsulated cell therapy for neurodegenerative diseases: From promise to product
TL;DR: Recent advances in human cell line development have increased the levels of secreted therapeutic molecules from encapsulated cells, and membrane extrusion techniques have led to the first ever clinical demonstrations of long-term survival and function of encapsulation cells in the brain parenchyma.
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Compacted DNA Nanoparticle Gene Transfer of GDNF to the Rat Striatum Enhances the Survival of Grafted Fetal Dopamine Neurons
TL;DR: Data analysis for protein, morphological, and behavioral measures suggests that compacted pGDNF DNPs injected into the striatum can result in transfected cells overexpressing GDNF protein at levels that provide neurotrophic support for grafted embryonic dopamine neurons.
References
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Journal ArticleDOI
Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
Curt R. Freed,Paul Greene,Robert E. Breeze,Wei-Yann Tsai,William DuMouchel,Richard Kao,Sandra Dillon,Howard Winfield,Sharon Culver,John Q. Trojanowski,David Eidelberg,Stanley Fahn +11 more
TL;DR: After improvement in the first year, dystonia and dyskinesias recurred in 15 percent of the patients who received transplants, even after reduction or discontinuation of the dose of levodopa.
Journal ArticleDOI
Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.
TL;DR: The nigrostriatal dopamine system of rats is unilaterally lesioned by intracerebral injection of 6-hydroxy-dopamine which produces an almost complete and selective lesion and the remaining contralateral dopamine system is activated by systemic treatment with amphetamine.
Journal ArticleDOI
Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
Steven S. Gill,Nikunj K. Patel,Gary Hotton,Karen O’Sullivan,Renée McCarter,Martin Bunnage,David J. Brooks,Clive N. Svendsen,Peter Heywood +8 more
TL;DR: Positron emission tomography scans of [18F]dopamine uptake showed a significant 28% increase in putamen dopamine storage after 18 months, suggesting a direct effect of GDNF on dopamine function, and warrants careful examination ofGDNF as a treatment for Parkinson disease.
Journal ArticleDOI
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.
Jeffrey H. Kordower,Marina E. Emborg,Jocelyne Bloch,Shuang Y. Ma,Yaping Chu,Liza Leventhal,Jodi L. McBride,Er-Yun Chen,Stéphane Palfi,Ben Roitberg,W. Douglas Brown,James E. Holden,Robert W. Pyzalski,Michael D. Taylor,Paul M. Carvey,Zaodung Ling,Didier Trono,Philippe Hantraye,Nicole Déglon,Patrick Aebischer,Patrick Aebischer +20 more
TL;DR: Data indicate that GDNF delivery using a lentiviral vector system can prevent nigrostriatal degeneration and induce regeneration in primate models of PD and might be a viable therapeutic strategy for PD patients.
Transplantation of embryonic dopamine neurons for severe parkinson's disease
R. F Reed,P Aul E. G Reene,R Obert E. B Reeze,W Ei,W Illiam D U M Ouchel,R Ichard K Ao,W Infield,S Haron C Ulver,J Ohn Q. T Rojanowski,D Avid E Idelberg,S Tanley F Ahn +10 more
TL;DR: For example, in this paper, the authors randomly assigned 40 patients who were 34 to 75 years of age and had severe Parkinson's disease (mean duration, 14 years) to receive a transplant of nerve cells or undergo sham surgery; all were to be followed in a double-blind manner for one year.
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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease.
Anthony E. Lang,Steven S. Gill,Nik K. Patel,Andres M. Lozano,John G. Nutt,Richard D. Penn,David J. Brooks,Gary Hotton,Elena Moro,Peter Heywood,Matthew Brodsky,Kim J. Burchiel,Patrick J. Kelly,Arif Dalvi,Burton L. Scott,Mark Stacy,Dennis A. Turner,V. G. Frederich Wooten,W. J. Elias,Edward R. Laws,Vijay Dhawan,A. Jon Stoessl,James Matcham,Robert J. Coffey,Michael Traub +24 more