Journal ArticleDOI
Induction of immune-related gene expression by seminal exosomes in the porcine endometrium.
TLDR
Observations indicated that exosomes present in SP are involved in the immune-related gene regulation in the uterus, which could pave the passage for sperm and possibly fertilized eggs.Citations
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Journal ArticleDOI
The Female Response to Seminal Fluid.
TL;DR: Male-female seminal fluid signaling is evident in all mammalian species investigated including human, and effects of seminal fluid in invertebrates indicate evolutionarily conserved mechanisms.
Journal ArticleDOI
A highly efficient method for isolating urinary exosomes
TL;DR: The results indicated that OUF clearly outperforms UC in quantity, quality and biological stability, and this improved method may have extensive applications in the growing fields of clinical biomarker discovery and exosome research.
Journal ArticleDOI
Driving the Next Generation: Paternal Lifetime Experiences Transmitted via Extracellular Vesicles and Their Small RNA Cargo.
TL;DR: The possibility that paternal extracellular vesicles could themselves serve as vectors, delivering signals not only to gametes or the zygote but also to tissues of the maternal reproductive tract to influence fetal development is explored.
Journal ArticleDOI
Extracellular vesicles isolated from porcine seminal plasma exhibit different tetraspanin expression profiles
Isabel Barranco,Lorena Padilla,Inmaculada Parrilla,Alberto Álvarez-Barrientos,Cristina Perez-Patiño,Fernando J. Peña,Emilio A. Martinez,Heriberto Rodriguez-Martinez,Jordi Roca +8 more
TL;DR: The new generation of flow cytometers are able to accurately identify EVs and to gate them in two size-different populations named exosomes and MVs, suggesting dissimilar cargo and binding affinity.
Journal ArticleDOI
Expression of Immune Regulatory Genes in the Porcine Internal Genital Tract Is Differentially Triggered by Spermatozoa and Seminal Plasma
Manuel Alvarez-Rodriguez,Mohammad Atikuzzaman,Mohammad Atikuzzaman,Heli Venhoranta,Dominic Wright,Heriberto Rodriguez-Martinez +5 more
TL;DR: Sperm-free SP, on the other hand, did not lead to major effects on gene expression, despite the clinical notion that SP mitigates reactivity by the female immune system after mating or artificial insemination.
References
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Journal ArticleDOI
Interleukin-6 and chronic inflammation.
TL;DR: Strategies targeting IL-6 andIL-6 signaling led to effective prevention and treatment of models of rheumatoid arthritis and other chronic inflammatory diseases.
Journal ArticleDOI
Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses
Angélique Bobrie,Marina Colombo,Marina Colombo,Marina Colombo,Graça Raposo,Graça Raposo,Clotilde Théry,Clotilde Théry +7 more
TL;DR: The current ideas on exosomes and immune responses are focused on their mechanisms of secretion and the use of this knowledge to elucidate the former issue, and on their capacity to vehicle genetic messages.
Journal ArticleDOI
Antioxidant strategies in the epididymis
TL;DR: The different sources of ROS are examined and then the antioxidant strategies that protect spermatozoa during epididymal transit are reviewed, with a major focus on the involvement of glutathione peroxidase.
Journal ArticleDOI
Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC
Masataka Baba,Toshio Imai,Miyuki Nishimura,Mayumi Kakizaki,Shin Takagi,Kunio Hieshima,Hisayuki Nomiyama,Osamu Yoshie +7 more
TL;DR: GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-Y4, which is proposed to be designated as CCR6.
Journal ArticleDOI
Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2
Kunio Hieshima,Toshio Imai,Ghislain Opdenakker,Jo Van Damme,Jun Kusuda,Hajime Tei,Yoshiyuki Sakaki,Kiyoshi Takatsuki,Retsu Miura,Osamu Yoshie,Hisayuki Nomiyama +10 more
TL;DR: This chemokine was mainly expressed in liver among various tissues and strongly induced in several human cell lines by phorbol myristate acetate and may represent a new group of CC chemokines localized on chromosome 2.
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