Journal ArticleDOI
Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential.
Sukant Garg,Sukant Garg,He Huifu,He Huifu,Anjani Kumari,Durai Sundar,Sunil C. Kaul,Renu Wadhwa,Renu Wadhwa +8 more
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TLDR
It is proposed that CucWi-N is a potential natural anticancer drug that warrants further mechanistic and clinical studies and possesses high capability to target mortalin-p53 interaction and hnRNP-K proteins.Abstract:
Cancer, an uncontrolled proliferation syndrome, is treated with synthetic chemotherapeutic drugs that are associated with severe adverse effects. Development and application of new natural compounds is warranted to deal with the exponentially increasing incidence of cancer worldwide. Keeping selective toxicity to cancer cells as a priority criterion, we developed a combination of Cucurbitacin B and Withanone, and analyzed its anticancer potential using non-small cell lung cancer cells. We demonstrate that the selective cytotoxicity of the combination, called CucWi-N, to cancer cells is mediated by induction of cellular senescence that was characterized by decrease in Lamin A/C, CDK2, CDK4, Cyclin D, Cyclin E, phosphorylated RB, mortalin and increase in p53 and CARF proteins. It compromised cancer cell migration that was mediated by decrease in mortalin, hnRNP-K, vascular endothelial growth factor, matrix metalloproteinase 2, and fibronectin. We provide in silico, molecular dynamics and experimental data to support that CucWi-N (i) possesses high capability to target mortalin-p53 interaction and hnRNP-K proteins, (ii) triggers replicative senescence and inhibits metastatic potential of the cancer cells, and (iii) inhibits tumor progression and metastasis in vivo. We propose that CucWi-N is a potential natural anticancer drug that warrants further mechanistic and clinical studies.read more
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Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine.
Hua Luo,Chi Teng Vong,Hanbin Chen,Yan Gao,Peng Lyu,Ling Qiu,Mingming Zhao,Qiao Liu,Zehua Cheng,Jian Zou,Peifen Yao,Caifang Gao,Jinchao Wei,Carolina Oi Lam Ung,Shengpeng Wang,Zhangfeng Zhong,Yitao Wang +16 more
TL;DR: The present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshin one in view of their potentials in cancer therapy.
Journal ArticleDOI
Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis
Renyikun Yuan,Wentong Zhao,Wentong Zhao,Qin-Qin Wang,Jia He,Shan Han,Hongwei Gao,Yulin Feng,Shilin Yang +8 more
TL;DR: In this paper, the exact molecular mechanisms and the direct targets of CuB in non-small cell lung cancer (NSCLC) remain to be discovered, however, the authors have shown that CuB exerted an anti-tumor effect via pyroptosis in NSCLC cells and mice models.
Journal ArticleDOI
Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence.
Sukant Garg,Sajal Afzal,Ahmed Elwakeel,Damini Sharma,Navaneethan Radhakrishnan,Jaspreet Kaur Dhanjal,Durai Sundar,Sunil C. Kaul,Renu Wadhwa +8 more
TL;DR: Investigation of fucoxanthin activities in human cancer cell culture-based viability, migration, and molecular assays found that it possesses strong anticancer and anti-metastatic activities that work irrespective of the p53 status of cancer cells.
Journal ArticleDOI
Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action.
Anissa Nofita Sari,Priyanshu Bhargava,Jaspreet Kaur Dhanjal,Jaspreet Kaur Dhanjal,Jayarani F. Putri,Navaneethan Radhakrishnan,seyad shefrin,Yoshiyuki Ishida,Keiji Terao,Durai Sundar,Sunil C. Kaul,Sunil C. Kaul,Renu Wadhwa,Renu Wadhwa +13 more
TL;DR: Experimental evidences are provided that Wi-A and CAPE cause inactivation of PARP1-mediated DNA repair leading to accumulation of DNA damage and activation of apoptosis signaling by multiple ways, and a combination of Wi- A andCAPE offers selective toxicity and better potency to cancer cells.
Journal ArticleDOI
Withania somnifera (L.) Dunal: Phytochemistry, structure-activity relationship, and anticancer potential.
Devesh Tewari,Vikas Chander,A. Dhyani,Sanjeev Kumar Sahu,Pawan Gupta,Pooja Patni,Lindsay S. Kalick,Anupam Bishayee +7 more
TL;DR: An updated review on the anticancer potential and mechanisms of action of the major bioactive components of W. somnifera, including withanolides, withaferin A and withanone, is presented in this paper .
References
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