Journal ArticleDOI
Inflammatory bowel disease (1)
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This article is published in The New England Journal of Medicine.The article was published on 1991-09-26. It has received 1204 citations till now. The article focuses on the topics: Inflammatory bowel disease.read more
Citations
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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.
TL;DR: It is reported that the Treg cells that control intestinal inflammation express the same phenotype (CD25+CD45RBlowCD4+) as those that control autoimmunity, suggesting that Treg cell function contributes to the immune suppression characteristic of CTLA-4 signaling.
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Inflammatory bowel disease: cause and immunobiology
TL;DR: How environmental factors, infectious microbes, ethnic origin, genetic susceptibility, and a dysregulated immune system can result in mucosal inflammation are discussed.
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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.
TL;DR: The data provide evidence for a primary role of the immune system in the etiology of ulcerative colitis and strongly suggest that the disease results from an abnormal immune response to a normal antigenic stimulus.
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Inflammatory bowel disease: clinical aspects and established and evolving therapies.
TL;DR: The current diagnostic approach, their pathology, natural course, and common complications, the assessment of disease activity, extraintestinal manifestations, and medical and surgical management are discussed, and diagnostic and therapeutic algorithms are provided.
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Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer
Yumi Yamamoto,Richard B. Gaynor +1 more
TL;DR: In this paper, the authors discuss cellular genes and disease states associated with activation of the NF-κB pathway and consider therapeutic strategies to prevent the prolonged activation of this pathway, such as glucocorticoids and aspirin.
References
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Journal ArticleDOI
Predictability of the postoperative course of Crohn's disease
TL;DR: The early postoperative lesions in the neoterminal ileum seem to be a suitable model to study the pathogenesis of Crohn's disease and also to evaluate new therapeutic modalities, either to prevent development of these early lesions or to treat progressive recurrence.
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Regional ileitis: a pathologic and clinical entity
TL;DR: A disease of the terminal ileum, affecting mainly young adults, characterized by a subacute or chronic necrotizing and cicatrizing inflammation, which frequently leads to stenosis of the lumen of the intestine, associated with the formation of multiple fistulas.
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Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders
TL;DR: It is established that B27 plays a central role in the pathogenesis of the multi-organ system processes of the spondyloarthropathies and elucidation of the role of B27 should be facilitated by this transgenic model.
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Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
TL;DR: By running the Swedish twin registry containing about 25,000 pairs of twins of the same sex together with the central national diagnosis register of hospital inpatients, 80 twin pairs suffering from inflammatory bowel disease were found and heredity as an aetiological factor is stronger in Crohn's disease than in ulcerative colitis.
Journal ArticleDOI
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
TL;DR: It is inferred that diversion colitis may represent an inflammatory state resulting from a nutritional deficiency in the lumen of the colonic epithelium, which is effectively treated by local application of short-chain fatty acids, the missing nutrients.
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Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more