Influenza vaccine effectiveness against medically attended influenza illness in Beijing, China, 2014/15 season.
Chunna Ma,Yang Pan,Li Zhang,Yi Zhang,Shuangsheng Wu,Ying Sun,Wei Duan,Man Zhang,Quanyi Wang,Peng Yang +9 more
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TLDR
The influenza VE against medically attended influenza-like illness (ILI) associated with laboratory-confirmed influenza virus infection using a test-negative design was estimated, and the effect of prior vaccination on current vaccination was examined.Abstract:
Influenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in China. Poor influenza vaccine effectiveness (VE) was reported in the 2014/15 ...read more
Citations
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Journal ArticleDOI
The Use of Test-negative Controls to Monitor Vaccine Effectiveness: A Systematic Review of Methodology
Huiying Chua,Shuo Feng,Joseph A Lewnard,Sheena G. Sullivan,Christopher C Blyth,Marc Lipsitch,Benjamin J. Cowling +6 more
TL;DR: If vaccination reduces disease severity in breakthrough infections, particular care must be taken in interpreting vaccine effectiveness estimates from test-negative design studies, including studies on VE against influenza virus, rotavirus, and nine other pathogens.
Journal ArticleDOI
Variable seasonal influenza vaccine effectiveness across geographical regions, age groups and levels of vaccine antigenic similarity with circulating virus strains: A systematic review and meta-analysis of the evidence from test-negative design studies after the 2009/10 influenza pandemic.
TL;DR: The authors examined the influence of some factors on seasonal influenza vaccine effectiveness from test-negative design (TND) studies, using an inverse variance, random-effects model, and found consistent patterns appear to exist in seasonal influenza VE across regions, age groups, and levels of vaccine antigenic similarity with circulating virus strains.
Journal ArticleDOI
Influenza vaccine effectiveness in preventing laboratory-confirmed influenza in outpatient settings: A test-negative case-control study in Beijing, China, 2016/17 season.
Shuangsheng Wu,Yang Pan,Xinxin Zhang,Li Zhang,Wei Duan,Chunna Ma,Yi Zhang,Man Zhang,Ying Sun,Peng Yang,Quanyi Wang,Jun Ma +11 more
TL;DR: A Amino acid substitutions in the hemagglutinin may contribute to the low VE against influenza A(H3N2) for this season.
Journal ArticleDOI
The 2015-2016 influenza epidemic in Beijing, China: Unlike elsewhere, circulation of influenza A(H3N2) with moderate vaccine effectiveness.
Li Zhang,Yang Pan,Volker Hackert,Wim van der Hoek,Adam Meijer,Thomas Krafft,Peng Yang,Quanyi Wang +7 more
TL;DR: Overall the 2015-2016 TIV was protective against influenza infection in Beijing, with higher VE against the A(H3N2) viruses compared to A (H1N1)pdm09 and B viruses.
Journal ArticleDOI
Influenza vaccine effectiveness estimates against influenza A(H3N2) and A(H1N1) pdm09 among children during school-based outbreaks in the 2016-2017 season in Beijing, China.
Li Zhang,Wim van der Hoek,Thomas Krafft,Eva Pilot,Liselotte van Asten,Ge Lin,Shuangsheng Wu,Wei Duan,Peng Yang,Peng Yang,Quanyi Wang +10 more
TL;DR: A study during school outbreaks found that VE of 2016–2017 TIV was moderate against influenza A(H3N2) as well as A( H1N1)pdm09 viruses.
References
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Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution.
Björn F. Koel,David F. Burke,Theo M. Bestebroer,Stefan van der Vliet,Gerben C. M. Zondag,Gaby Vervaet,Eugene Skepner,Nicola S. Lewis,Monique I. J. Spronken,Colin A. Russell,Mikhail Y. Eropkin,Aeron C. Hurt,Ian G. Barr,Jan C. de Jong,Guus F. Rimmelzwaan,Albert D. M. E. Osterhaus,Ron A. M. Fouchier,Derek J. Smith +17 more
TL;DR: The findings of Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions, which substantially skew the way the immune system “sees” the virus.
Journal ArticleDOI
The test-negative design for estimating influenza vaccine effectiveness.
TL;DR: It is shown that test-negative studies of influenza VE can produce biased VE estimates if they include persons seeking care for ARI when influenza is not circulating or do not adjust for calendar time.
Journal ArticleDOI
Influenza Vaccine Effectiveness in the 2011–2012 Season: Protection Against Each Circulating Virus and the Effect of Prior Vaccination on Estimates
Suzanne E. Ohmit,Mark G. Thompson,Joshua G. Petrie,Swathi N. Thaker,Michael L. Jackson,Edward A. Belongia,Richard K. Zimmerman,Manjusha Gaglani,Lois Lamerato,Sarah Spencer,Lisa A. Jackson,Jennifer K. Meece,Mary Patricia Nowalk,Juhee Song,Marcus J. Zervos,Po Yung Cheng,Charles R. Rinaldo,Lydia Clipper,David K. Shay,Pedro A. Piedra,Arnold S. Monto +20 more
TL;DR: Vine effectiveness in the 2011-2012 season was modest overall, with lower effectiveness against the predominant A (H3N2) virus, which may be related to antigenic drift, but past history of vaccination might also play a role.
Journal ArticleDOI
The case test-negative design for studies of the effectiveness of influenza vaccine.
TL;DR: Under sets of increasingly general assumptions, it is found that the case test-negative design can provide unbiased VE estimates, but if vaccinated cases are less severely ill and seek care less frequently than unvaccinated cases, then an appropriate adjustment for illness severity is required to avoid bias in effectiveness estimates.
Journal ArticleDOI
2014-2015 Influenza Vaccine Effectiveness in the United States by Vaccine Type.
Richard K. Zimmerman,Mary Patricia Nowalk,Jessie R Chung,Michael L. Jackson,Lisa A. Jackson,Joshua G. Petrie,Arnold S. Monto,Huong Q. McLean,Edward A. Belongia,Manjusha Gaglani,Kempapura Murthy,Alicia M. Fry,Brendan Flannery,US Flu Ve Investigators +13 more
TL;DR: The 2014-2015 influenza vaccines offered little protection against the predominant influenza A/H3N2 virus but were effective against influenza B and preferential use of LAIV among young children was not supported.
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Brendan Flannery,Jessie R Chung,Edward A. Belongia,Huong Q. McLean,Manjusha Gaglani,Kempapura Murthy,Richard K. Zimmerman,Mary Patricia Nowalk,Michael L. Jackson,Lisa A. Jackson,Arnold S. Monto,Emily T. Martin,Angie Foust,Wendy Sessions,LaShondra Berman,John R. Barnes,Sarah Spencer,Alicia M. Fry +17 more