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Open AccessJournal ArticleDOI

Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis

- 01 May 2022 - 
- Vol. 12, Iss: 5, pp 2522-2532
TLDR
In this paper , curcumin-loaded mesoporous polydopamine nanoparticles (CMPN) were used to prevent and treat radiation pneumonitis (RP) by pulmonary delivery.
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This article is published in Acta Pharmaceutica Sinica B.The article was published on 2022-05-01 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Curcumin & Mesoporous material.

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Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers

TL;DR: A summary of the role of curcumin as both a radiosensitizer and radioprotector has been presented, based on the most recent data from the experimental and clinical evaluation ofCurcumin in different cancer cell lines, animal models, and human patients.
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Advances in Delivering Oxidative Modulators for Disease Therapy

TL;DR: Pilot designs for delivering the oxidative modulators and the main applications for inflammatory treatment and tumor therapy, and prospects for future research are provided to identify intelligent strategies and inspire new concepts for delivering oxidative modulator.
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Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury

TL;DR: In this article , the activation of NLRP3 inflammasome in lung epithelial cells was screened by qRT-PCR, western blotting, immunofluorescence, and ELISA.
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Therapeutic potential and limitations of curcumin as antimetastatic agent.

TL;DR: In this paper , the potential of curcumin as an antimetastatic agent and potential mechanisms of its antimetastic activity are discussed. And possible strategies (curcumin formulation, optimization of the method of administration and modification of its structure motif) to overcome its limitation such as low solubility and bioactivity are also presented.
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Pore-engineered nanoarchitectonics for cancer therapy

TL;DR: In this paper , a review of pore-engineered nano-architectures with application targets for cancer therapy by combining basic descriptions and exemplifying therapy applications is presented, where mesoporous materials are unique nanoparticles that offer a network of cavities as vehicles for drug nanocarriers.
References
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The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

TL;DR: A greater understanding is required of the mechanisms by which glucocorticoids exert their anti-inflammatory and immunosuppressive actions, and recent research is shedding new light on some of these mechanisms and has produced some surprising new findings.
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Immune regulation by glucocorticoids

TL;DR: This Review distil several decades of intense (and often conflicting) research that defines the interface between the endocrine stress response and the immune system.
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Insoluble drug delivery strategies: review of recent advances and business prospects

TL;DR: A review of the recent advances in the field of insoluble drug delivery and business prospects covers the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility.
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Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review

TL;DR: In this paper, the authors highlight the recent development of smart drug delivery systems for a number of smart nanocarriers, including liposomes, micelles, dendrimers, meso-porous silica nanoparticles, gold nanoparticles and carbon nanotubes.
Journal ArticleDOI

Radiation-Induced Lung Injury: Assessment and Management.

TL;DR: Current research advances include high-precision radiation techniques, an improved understanding of the molecular basis of RILI, the development of small and large animal models, and the identification of candidate drugs for prevention and treatment.
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