Journal ArticleDOI
Inhibition of N-, P/Q- and other types of Ca2+ channels in rat hippocampal nerve terminals by the adenosine A1 receptor
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TLDR
The present results suggest that, in hippocampal glutamatergic nerve terminals, adenosine A1 receptor activation partly inhibits P/Q- and other non-identified types of Ca2+ channels.About:
This article is published in European Journal of Pharmacology.The article was published on 1997-12-11. It has received 79 citations till now. The article focuses on the topics: Adenosine A1 receptor & Adenosine.read more
Citations
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Book ChapterDOI
Adenosine and Brain Function
TL;DR: Much additional work is needed to pinpoint the sites and mechanisms of action, as well as the roles in chronic pain states of adenosine A 2A receptors in neurodegenerative disorders and ARs in psychiatric disorders.
Journal ArticleDOI
Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors
TL;DR: Evidence is presented to suggest that adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic modulator and also as a neuromodulator at the synaptic level, which originated from different metabolic sources, and involve receptors with different sub-cellular localisation.
Journal ArticleDOI
Adenosine receptors and brain diseases: neuroprotection and neurodegeneration.
Catarina Alexandra dos Reis Vale Gomes,Manuella P. Kaster,Angelo R. Tomé,Paula Agostinho,Rodrigo A. Cunha +4 more
TL;DR: It seems evident that targeting adenosine receptors might indeed constitute a novel strategy to control the demise of different neurological and psychiatric disorders.
Journal ArticleDOI
How does adenosine control neuronal dysfunction and neurodegeneration
TL;DR: The adenosine modulation system mostly operates through inhibitory A1 (A1R) and facilitatory A2A receptors (A2AR) in the brain, and simultaneously bolstering A1R preconditioning and preventing excessive A2AR function might afford maximal neuroprotection.
Journal ArticleDOI
Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition
TL;DR: The results suggest that A 2A receptor agonists facilitate hippocampal synaptic transmission by attenuating the tonic effect of inhibitory presynaptic A 1 receptors located in glutamatergic nerve terminals.
References
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Journal ArticleDOI
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
TL;DR: A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+ using an 8-coordinate tetracarboxylate chelating site with stilbene chromophores that offer up to 30-fold brighter fluorescence.
Book ChapterDOI
Spectrophotometric and turbidimetric methods for measuring proteins
TL;DR: The turbidity produced when protein is mixed with low concentrations of any of the common protein precipitants can be used as an index of protein concentration, and this advantage is used to eliminate the interference of nucleic acids in the estimation of protein.
Journal ArticleDOI
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission
TL;DR: A role for alpha 1A subunits in synaptic transmission is suggested and the idea that neurotransmitter release may depend on multiple types of calcium channels under physiological conditions is supported.
Journal ArticleDOI
How does adenosine inhibit transmitter release
TL;DR: It is suggested that adenosine may depress transmitter release in several ways and that the relative importance of these presynaptic actions may vary between nerve terminals.
Journal ArticleDOI
Presynaptic inhibition of elicited neurotransmitter release
Ling-Gang Wu,Peter Saggau +1 more
TL;DR: Evidence at synapses suggests that inhibition of presynaptic voltage-dependent Ca2+ channels plays the major role inPresynaptic inhibition of elicited neurotransmitter release, and modulation of the release machinery might contribute to inhibition of elicit release.
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The Role and Regulation of Adenosine in the Central Nervous System
Adenosine in the central nervous system: release mechanisms and extracellular concentrations.
Serena Latini,Felicita Pedata +1 more