Journal ArticleDOI
Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds
TLDR
It is demonstrated that cannabinoid and nantradol compounds decrease cyclic AMP accumulation in neuronally derived cells, and that this results from an inhibition of basal and hormone-stimulated adenylate cyclase activity.About:
This article is published in Life Sciences.The article was published on 1984-10-22. It has received 147 citations till now. The article focuses on the topics: Cyclase activity & Cyclase.read more
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Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system.
TL;DR: The results generally agree well with the previous studies using CB1 receptor autoradiography and messenger RNA in situ hybridization, but because of its greater resolution, immunohistochemistry allowed identification of particular neuronal cells and fibers that possess cannabinoid receptors.
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Pharmacology of cannabinoid cb1 and cb2 receptors
TL;DR: This review focuses on the classification, binding properties, effector systems and distribution of cannabinoid receptors, and describes the various cannabinoid receptor agonists and antagonists now available and considers the main in vivo and in vitro bioassay methods that are generally used.
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Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain.
TL;DR: The anatomical distribution and density of cannabinoid receptors in the human brain was studied in one fetal, two neonatal and eight adult human cases using quantitative receptor autoradiography following in vitro labelling of sections with the synthetic cannabinoid agonist [3H]CP55,940.
Journal ArticleDOI
Cannabinoid physiology and pharmacology: 30 years of progress
Allyn C. Howlett,Allyn C. Howlett,Christopher S. Breivogel,Steven R. Childers,Sam A. Deadwyler,Robert E. Hampson,Linda J. Porrino +6 more
TL;DR: Delta9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528, through G-protein-coupled receptors, CB1 in the brain, and CB2 in the immune system.
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Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
TL;DR: Assays of different central nervous system (CNS) regions demonstrated significant activity of cannabinoids in CB(1)(-/-) membranes from brain stem, cortex, hippocampus, diencephalon, midbrain, and spinal cord, but not basal ganglia or cerebellum.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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A Highly Sensitive Adenylate Cyclase Assay
TL;DR: The high sensitivity of this method permits detection of the small amounts of cyclic AMP formed at low enzyme concentrations or at early time points in kinetic studies.
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Multiple cyclic nucleotide phosphodiesterase activities from rat brain
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Further studies of the lipid composition and biochemical properties of Tetrahymena pyriformis membrane systems.
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Physicochemical Properties, Solubility, and Protein Binding of Δ9 -Tetrahydrocannabinol
TL;DR: The rate and extent of glass binding of Δ9 -tetrahydrocannabinol in aqueous solution depend on the surface area and pretreatment of glass and the concentration of the drug as mentioned in this paper.