Inhibition of PCSK9 Transcription by Berberine Involves Down-regulation of Hepatic HNF1α Protein Expression through the Ubiquitin-Proteasome Degradation Pathway
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TLDR
The studies using BBR as a probe uncovered a new aspect of PCSK9 regulation by ubiquitin-induced proteasomal degradation of HNF1α, and it is shown that the BBR reducing effects on H NF1α protein andPCSK9 gene transcription can be eradicated by proteasome inhibitors.About:
This article is published in Journal of Biological Chemistry.The article was published on 2015-02-13 and is currently open access. It has received 106 citations till now. The article focuses on the topics: MG132 & Proteasome.read more
Citations
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Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.
TL;DR: In this article, the sterol-regulatory element binding protein-1 (SREBP-1) was found to increase the promoter activity of Proprotein convertase subtilisin/kexin type 9.
Journal ArticleDOI
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies.
Suowen Xu,Iqra Ilyas,Peter J. Little,Hong Li,Danielle Kamato,Xueying Zheng,Sihui Luo,Zhuoming Li,Peiqing Liu,Jihong Han,Ian C. Harding,Eno E. Ebong,Scott J. Cameron,Alastair G. Stewart,Jianping Weng +14 more
TL;DR: In this article, the authors provide a timely overview of the multiple layers of endothelial function, describe the consequences and mechanisms of the endothelial dysfunction, and identify pathways to effective targeted therapies.
Journal ArticleDOI
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Xiaojun Feng,Antoni Sureda,Samineh Jafari,Zahra Memariani,Devesh Tewari,Giuseppe Annunziata,Luigi Barrea,Sherif T. S. Hassan,Karel Šmejkal,Milan Malaník,Alice Sychrová,Davide Barreca,Lovro Ziberna,Mohamad Fawzi Mahomoodally,Gokhan Zengin,Suowen Xu,Seyed Mohammad Nabavi,Aizong Shen +17 more
TL;DR: A timely overview of the pharmacological properties and therapeutic application of BBR in CVMD is provided, and recent pharmacological advances which validate BBR as a promising lead drug against CVMD are underlined.
Book ChapterDOI
Berberine and Its Role in Chronic Disease
TL;DR: Preliminary clinical evidence suggest the ability of berberine to reduce endothelial inflammation improving vascular health, even in patients already affected by cardiovascular diseases, and a possible application in the management of chronic cardiometabolic disorders.
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Functional foods and dietary supplements for the management of dyslipidaemia.
Paola M. Hunter,Robert A. Hegele +1 more
TL;DR: Natural health products marketed at individuals with dyslipidaemia, such as policosanol, guggulsterone and resveratrol, have minimal definitive evidence of a biochemical benefit.
References
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Basic Medical Research Award. The ubiquitin system.
TL;DR: The ubiquitin system plays important roles in the control of numerous processes, including cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation, and endocytosis as mentioned in this paper.
Journal ArticleDOI
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
Jay D. Horton,Nila Shah,Janet A. Warrington,Norma N. Anderson,Sahng Wook Park,Michael S. Brown,Joseph L. Goldstein +6 more
TL;DR: Through application of stringent combinatorial criteria, the transgenic/knockout approach allows identification of genes whose activities are likely to be controlled directly by one family of transcription factors, in this case the SREBPs.
Journal ArticleDOI
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.
Wei-Jia Kong,Jing Wei,Parveen Abidi,Meihong Lin,Satoru Inaba,Cong Li,Yanling Wang,Zi-Zheng Wang,Shuyi Si,Huai-Ning Pan,Shukui Wang,Jingdan Wu,Yue Wang,Zhuorong Li,Jingwen Liu,Jian-Dong Jiang,Jian-Dong Jiang +16 more
TL;DR: Findings show berberine (BBR) as a new hypolipidemic drug with a mechanism of action different from that of statin drugs.
Journal ArticleDOI
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
Nabil G. Seidah,Suzanne Benjannet,Louise Wickham,Jadwiga Marcinkiewicz,Stephanie Belanger Jasmin,Stefano Stifani,Ajoy Basak,Annik Prat,Michel Chrétien +8 more
TL;DR: The properties of a proteinase K-like subtilase, neural apoptosis-regulated convertase 1 (NARC-1), representing the ninth member of the secretory subtilases family, are described, suggesting that NARC- 1 is implicated in the differentiation of cortical neurons.
Journal ArticleDOI
Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation
Da-Wei Zhang,Thomas A. Lagace,Rita Garuti,Zhenze Zhao,Meghan McDonald,Jay D. Horton,Jonathan Cohen,Helen H. Hobbs +7 more
TL;DR: Data are consistent with a model in which PCSK9 binding to EGF-A interferes with an acid-dependent conformational change required for receptor recycling, and the LDLR is rerouted from the endosome to the lysosome where it is degraded.
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