Journal ArticleDOI
Interictal plasma pituitary adenylate cyclase-activating polypeptide levels are decreased in migraineurs but remain unchanged in patients with tension-type headache.
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TLDR
Differences in interictal PACAP levels in migraine and TTH are demonstrated, suggesting that PACAP is involved in the pathogenesis of migraine rather than TTH.About:
This article is published in Clinica Chimica Acta.The article was published on 2015-10-23. It has received 27 citations till now. The article focuses on the topics: Chronic Migraine & Migraine.read more
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Human models of migraine - short-term pain for long-term gain.
TL;DR: The existing experimental models of migraine in humans, including those that exploit nitric oxide, histamine, neuropeptide and prostaglandin signalling, are summarized and the development and use of these models in the discovery of molecular pathways that are responsible for initiation of migraine attacks are described.
Journal ArticleDOI
PACAP and its role in primary headaches
TL;DR: It is suggested that the activation of the trigeminal system may result in elevated venous levels of PACAP, a change that can be reduced when headache is treated, and PACAP and its receptors may be promising targets for migraine therapeutics.
Journal ArticleDOI
Chronic migraine: A process of dysmodulation and sensitization.
Min Su,Shengyuan Yu +1 more
TL;DR: The latest data is reviewed to outline the clinical feature, pathophysiological mechanism, and management of chronic migraine, in the expectation to provide direction for future research and finally to take good care of Chronic migraine patients.
Journal ArticleDOI
Neuropeptides as a Marker for Chronic Headache
TL;DR: Current data on TVS neuropeptides as potential migraine biomarkers must be taken with caution, even for the promising case of CGRP, as there are no data for other parasympathetic peptides.
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Perivascular neurotransmitters: Regulation of cerebral blood flow and role in primary headaches.
Simona Denise Frederiksen,Kristian Agmund Haanes,Karin Warfvinge,Karin Warfvinge,Lars Edvinsson,Lars Edvinsson +5 more
TL;DR: A literature review with particular emphasis on the role of perivascular neurotransmitters supports a role for the vasculature in primary headache disorders.
References
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Journal ArticleDOI
The International Classification of Headache Disorders, 3rd edition (beta version)
Jes Olesen,André Bes,Robert S. Kunkel,James W. Lance,Giuseppe Nappi,V Pfaffenrath,Frank Clifford Rose,Bruce S. Schoenberg,D. Soyka,Peer Tfelt-Hansen,K. Michael A. Welch,Marica Wilkinson,Marie-Germaine Bousser,Hans-Christoph Diener,David W. Dodick,Michael First,Peter J. Goadsby,Hartmut Göbel,Miguel J. A. Láinez,Richard B. Lipton,Fumihiko Sakai,Jean Schoenen,Stephen D. Silberstein,Timothy J. Steiner,Lars Bendtsen,Anne Ducros,Stefan Evers,Andrew D. Hershey,Zaza Katsarava,Morris Levin,Julio Pascual,Michael Bjørn Russell,Todd J. Schwedt,Cristina Tassorelli,Gisela M. Terwindt,Maurice Vincent,Shuu Jiun Wang,Andrew Charles,R. Lipton,Hayrunnisa Bolay,Michel Lantéri-Minet,E. A. Macgregor,T. Takeshima,Henrik Winther Schytz,S. Ashina,M. T. Goicochea,K. Hirata,Kenneth A. Holroyd,Christian Lampl,Dimos-Dimitrios Mitsikostas,P. Goadsby,C. Boes,C. Bordini,E. Cittadini,Andrew I. Cohen,M. Leone,A. May,L. Newman,J. Pareja,J. W. Park,T. Rozen,E. Waldenlind,Jong Ling Fuh,Aynur Özge,J. A. Pareja,Mario Fernando Prieto Peres,William B. Young,S. Y. Yu,Ishaq Abu-Arafeh,J. Gladstone,S. J. Huang,Rigmor Jensen,J.M. Láinez,D. Obelieniene,Peter S. Sandor,A. I. Scher,Marcel Arnold,Martin Dichgans,E. Houdart,José M. Ferro,Elizabeth Leroux,Y. S. Li,Aneesh B. Singhal,Gretchen E. Tietjen,Deborah I. Friedman,S. Kirby,B. Mokri,A. Purdy,K. Ravishankar,W. Schievink,R. Stark,F. Taylor,A. V. Krymchantowski,A. Tugrul,N. J. Wiendels,E. Marchioni,V. V. Osipova,Lidia Savi,J. R. Berger,Marcelo E. Bigal,J. González Menacho,Federico Mainardi,J. Pereira-Monteiro,M. Serrano-Dueñas,Roger Cady,C. Fernandez de las Peñas,Vincenzo Guidetti,J. Lance,Peter Svensson,Elizabeth Loder,A. E. Lake,Françoise Radat,J. I. Escobar,R. Benoliel,Claudia Sommer,A. Woda,Joanna M Zakrzewska,V. Aggarwal,L. Bonamico,Dominik A Ettlin,S. Graff-Radford,Jean-Paul Goulet,S. Jääskeläinen,Volker Limmroth,Ambra Michelotti,Donald R. Nixdorf,Mark Obermann,Richard Ohrbach,Paul Pionchon,Tara Renton,S. De Siqueira,Çiçek Wöber-Bingöl +131 more
TL;DR: The International Classification of Headache Disorders, 3 edition (beta version), may be reproduced freely for scientific, educational or clinical uses by institutions, societies or individuals as mentioned in this paper. But the authors require the permission of the International Headache Society.
Journal ArticleDOI
The Global Burden of Headache: A Documentation of Headache Prevalence and Disability Worldwide:
Lars Jacob Stovner,Knut Hagen,Rigmor Jensen,Zaza Katsarava,Richard B. Lipton,Ann I. Scher,Timothy J. Steiner,John-Anker Zwart +7 more
TL;DR: The calculations indicate that the disability attributable to tension-type headache is larger worldwide than that due to migraine, which would bring headache disorders into the 10 most disabling conditions for the two genders, and into the five most disabling for women.
Journal ArticleDOI
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
David Vaudry,Anthony Falluel-Morel,Steve Bourgault,Magali Basille,Delphine Burel,Olivier Wurtz,Alain Fournier,Billy K. C. Chow,Hitoshi Hashimoto,Ludovic Galas,Hubert Vaudry +10 more
TL;DR: The present report reviews the current knowledge concerning the pleiotropic actions of PACAP and discusses its possible use for future therapeutic applications.
Journal ArticleDOI
PACAP38 induces migraine-like attacks in patients with migraine without aura.
Henrik Winther Schytz,Steffen Birk,Troels Wienecke,Christina Kruuse,Jes Olesen,Messoud Ashina +5 more
TL;DR: Pituitary adenylate cyclase activating peptide-38 infusion caused headache and vasodilatation in both healthy subjects and migraine patients and caused delayed migraine-like attacks in migraine sufferers.
Journal ArticleDOI
The Prevalence and Burden of Primary Headaches in China: A Population‐Based Door‐to‐Door Survey
Shengyuan Yu,Ruozhuo Liu,Gang Zhao,Xiaosu Yang,Xiangyang Qiao,Jiachun Feng,Yannan Fang,Xiutang Cao,Mianwang He,Timothy J. Steiner +9 more
TL;DR: A population‐based survey was initiated by Lifting The Burden: the Global Campaign against Headache to investigate the prevalence and burden of primary headache disorders in the mainland of China.