Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
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TLDR
Results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.Abstract:
Airways inflammation is thought to play a central role in the pathogenesis of asthma. However, the precise role that individual inflammatory cells and mediators play in the development of airways hyperreactivity and the morphological changes of the lung during allergic pulmonary inflammation is unknown. In this investigation we have used a mouse model of allergic pulmonary inflammation and interleukin (IL) 5-deficient mice to establish the essential role of this cytokine and eosinophils in the initiation of aeroallergen-induced lung damage and the development of airways hyperreactivity. Sensitization and aerosol challenge of mice with ovalbumin results in airways eosinophilia and extensive lung damage analogous to that seen in asthma. Aeroallergen-challenged mice also display airways hyperreactivity to beta-methacholine. In IL-5-deficient mice, the eosinophilia, lung damage, and airways hyperreactivity normally resulting from aeroallergen challenge were abolished. Reconstitution of IL-5 production with recombinant vaccinia viruses engineered to express this factor completely restored aeroallergen-induced eosinophilia and airways dysfunction. These results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.read more
Citations
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Role of intercellular adhesion molecule-1 in a murine model of toluene diisocyanate-induced asthma.
Shiho Furusho,Shigeharu Myou,Masaki Fujimura,Toshiyuki Kita,Masahide Yasui,Kazuo Kasahara,Shinji Nakao,Kazuhiko Takehara,Shinichi Sato +8 more
TL;DR: This work has shown that the involvement of ICAM‐1 in toluene diisocyanate (TDI) asthma is currently unclear, and some differences from allergic asthma have been noted, including airway neutrophilia.
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Anti-interleukin 5 strategies as a potential treatment for asthma.
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Interleukin 7 receptor is required for myeloid cell homeostasis and reconstitution by hematopoietic stem cells.
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Acute effects of ozone exposure on lung function in mice sensitized to ovalbumin.
Tsuneo Yamauchi,Masayuki Shima,Tomoyuki Kuwaki,Michiko Ando,Masayoshi Ohmichi,Yasuichiro Fukuda,Motoaki Adachi +6 more
TL;DR: The results indicated that sensitization of the immune system to ovalbumin might be a risk factor which aggravates the effects of ozone exposure on the respiratory system.
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