Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
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Results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.Abstract:
Airways inflammation is thought to play a central role in the pathogenesis of asthma. However, the precise role that individual inflammatory cells and mediators play in the development of airways hyperreactivity and the morphological changes of the lung during allergic pulmonary inflammation is unknown. In this investigation we have used a mouse model of allergic pulmonary inflammation and interleukin (IL) 5-deficient mice to establish the essential role of this cytokine and eosinophils in the initiation of aeroallergen-induced lung damage and the development of airways hyperreactivity. Sensitization and aerosol challenge of mice with ovalbumin results in airways eosinophilia and extensive lung damage analogous to that seen in asthma. Aeroallergen-challenged mice also display airways hyperreactivity to beta-methacholine. In IL-5-deficient mice, the eosinophilia, lung damage, and airways hyperreactivity normally resulting from aeroallergen challenge were abolished. Reconstitution of IL-5 production with recombinant vaccinia viruses engineered to express this factor completely restored aeroallergen-induced eosinophilia and airways dysfunction. These results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.read more
Citations
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Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma.
Alexandre de Paula Rogerio,Caroline Fontanari,Erica Borducchi,Alexandre C. Keller,Monitchilo Russo,Edson Garcia Soares,D. A. Albuquerque,Lúcia Helena Faccioli +7 more
TL;DR: L. pacari and ellagic acid are effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies and curative anti-inflammatory effects, respectively.
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Interleukin-5 in the Pathophysiology of Severe Asthma
Corrado Pelaia,Giovanni Paoletti,Francesca Puggioni,Francesca Racca,Girolamo Pelaia,Giorgio Walter Canonica,Enrico Heffler +6 more
TL;DR: IL-5 is a suitable target for add-on biological therapies based on either IL-5 inhibition or blockade of its receptor (benralizumab), and can result in being definitely beneficial for patients with severe type 2 (T2)-high eosinophilic asthma, refractory to conventional anti-inflammatory drugs such as inhaled and even systemic corticosteroids.
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Targeting the Interleukin-5 Pathway for Treatment of Eosinophilic Conditions Other than Asthma.
TL;DR: Results of clinical trials evaluating the efficacy and safety of these new antibodies in diseases with prominent tissue eosinophilia are reviewed, followed by safety considerations and potential future applications.
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Pulmonary T cells and eosinophils: Coconspirators or independent triggers of allergic respiratory pathology?
TL;DR: Data from both asthmatic patient and mouse models of allergic respiratory inflammation suggest that, in addition to cell-autonomous activities, T-cell and eosinophil interactions may be critical to the onset and progression of pulmonary pathology.
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Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge.
Arihiko Kanehiro,Toshihide Ikemura,Mika J. Mäkelä,Michael Lahn,Anthony Joetham,Azzeddine Dakhama,Erwin W. Gelfand +6 more
TL;DR: It is confirmed that IL-5 dependent eosinophilic inflammation plays an essential role in the development of certain aspects of airway function after rechallenge of sensitized mice and that lymphocytes and neutrophils are also important in theDevelopment of altered airwayfunction.
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