Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
Reads0
Chats0
TLDR
Results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.Abstract:
Airways inflammation is thought to play a central role in the pathogenesis of asthma. However, the precise role that individual inflammatory cells and mediators play in the development of airways hyperreactivity and the morphological changes of the lung during allergic pulmonary inflammation is unknown. In this investigation we have used a mouse model of allergic pulmonary inflammation and interleukin (IL) 5-deficient mice to establish the essential role of this cytokine and eosinophils in the initiation of aeroallergen-induced lung damage and the development of airways hyperreactivity. Sensitization and aerosol challenge of mice with ovalbumin results in airways eosinophilia and extensive lung damage analogous to that seen in asthma. Aeroallergen-challenged mice also display airways hyperreactivity to beta-methacholine. In IL-5-deficient mice, the eosinophilia, lung damage, and airways hyperreactivity normally resulting from aeroallergen challenge were abolished. Reconstitution of IL-5 production with recombinant vaccinia viruses engineered to express this factor completely restored aeroallergen-induced eosinophilia and airways dysfunction. These results indicate that IL-5 and eosinophils are central mediators in the pathogenesis of allergic lung disease.read more
Citations
More filters
Journal ArticleDOI
Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity.
TL;DR: This study provides the first direct demonstration that allergic conditions, particularly in airways, may inhibit immune responses to concomitant virus infection and suggests that transient mucosal IL‐12 gene therapy represents an effective approach to both the prevention and treatment of allergic airways disease and associated immunosuppression of CMI.
Journal ArticleDOI
Prolonged Eosinophil Accumulation in Allergic Lung Interstitium of ICAM-2-Deficient Mice Results in Extended Hyperresponsiveness
Nicole Gerwin,Jose-Angel Gonzalo,Jose-Angel Gonzalo,Clare M. Lloyd,Clare M. Lloyd,Anthony J. Coyle,Yvonne Reiss,Naheed Banu,Baoping Wang,Hong Xu,Hava Avraham,Britta Engelhardt,Timothy A. Springer,Jose C. Gutierrez-Ramos,Jose C. Gutierrez-Ramos +14 more
TL;DR: An essential role for ICAM-2 is revealed in the development of the inflammatory and respiratory components of allergic lung disease and increased and prolonged accumulation of eosinophils in lung interstitium results in prolonged, heightened airway hyperresponsiveness.
Journal ArticleDOI
Chemokines in allergy.
Bernhard Homey,Albert Zlotnik +1 more
TL;DR: A better understanding of the complex mechanisms involved in leukocyte recruitment and inflammation as well as their potential role in the immunopathogenesis of human diseases is given.
Journal ArticleDOI
Vitamin E inhibits IL-4 gene expression in peripheral blood T cells.
TL;DR: Investigation of the molecular mechanism by which vitamin E suppressesIL‐4 transcription shows that it blocks binding of transcription factors to two important IL‐4 promoter binding sites for NF‐κB and AP‐1 and interferes with promoter activity upon T cell activation.
Journal ArticleDOI
Antioxidant and Anti-Inflammatory Effects of Resveratrol in Airway Disease
TL;DR: It is concluded that resveratrol has potential as a therapeutic agent in respiratory disease, which should be further investigated.
References
More filters
Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Cellular events in the bronchi in mild asthma and after bronchial provocation.
TL;DR: It is concluded that allergic asthma is accompanied by extensive inflammatory changes in the airways, even in mild clinical and subclinical disease.
Journal ArticleDOI
Macrophages and polymorphonuclear neutrophils in lung defense and injury
Yves Sibille,Herbert Y. Reynolds +1 more
TL;DR: Alveolar macrophages are part of the regulatory mechanisms of PMN mobility and adherence that appears to be crucial in the initiation of some inflammatory reactions, and this supports a central role for alveolarmacrophages in the regulation of PMn traffic in the lungs.
Journal ArticleDOI
Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions.
TL;DR: Bronchoalveolar lavage was performed in 19 asthmatic patients and in 5 control subjects to suggest that eosinophils and their mediators might be involved in the development of LAR after allergen inhalation.
Journal ArticleDOI
Recombinant human interleukin 5 is a selective activator of human eosinophil function.
Angel F. Lopez,Colin J. Sanderson,Jennifer R. Gamble,Hugh Campbell,Ian G. Young,Mathew A. Vadas +5 more
TL;DR: Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils, and is thus a prime candidate for the selective eOSinophilia and eos inophil activation seen in disease.