Journal ArticleDOI
Interleukin-5 Messenger RNA and Immunoreactive Protein Expression by Activated Eosinophils in Lesional Atopic Dermatitis Skin
Yoichi Tanaka,Emmanuel Delaporte,Sylvain Dubucquoi,Abdelilah S. Gounni,Eliane Porchet,André Capron,Monique Capron +6 more
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TLDR
It is found that dermal eosinophils from lesional atopic dermatitis skin express IL-5 mRNA and protein, which might suggest an autocrine pathway of eOSinophil differentiation and activation.About:
This article is published in Journal of Investigative Dermatology.The article was published on 1994-10-01. It has received 50 citations till now. The article focuses on the topics: Eosinophil cationic protein & Interleukin 5.read more
Citations
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Anti-IL-5 recombinant humanized monoclonal antibody (Mepolizumab) for the treatment of atopic dermatitis
J. M. Oldhoff,Ulf Darsow,Thomas Werfel,K. Katzer,A. Wulf,J. Laifaoui,DirkJan Hijnen,Sabine Gisela Plötz,Edward F. Knol,Alexander Kapp,C. A. F. M. Bruijnzeel-Koomen,Johannes Ring,M S de Bruin-Weller +12 more
TL;DR: This study was designed to study the effect of mepolizumab in AD, a monoclonal antibody to human interleukin‐5 that was developed for atopic diseases.
Journal ArticleDOI
A role for eosinophils in airway remodelling in asthma
TL;DR: More effective eosinophil-depleting agents than anti-IL-5 are required before the definitive role of this cell type in asthma airway pathophysiology can be established.
Journal ArticleDOI
Th2 cytokines and asthma — The role of interleukin-5 in allergic eosinophilic disease
TL;DR: The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukIn-5 monoclonal antibodies for the treatment of asthma in humans.
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Molecular and clinical rationale for therapeutic targeting of interleukin‐5 and its receptor
TL;DR: Interleukin‐5 is a Th2 homodimeric cytokine involved in the differentiation, maturation, migration, development, survival, trafficking and effector function of blood and local tissue eosinophils, in addition to basophils and mast cells.
References
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Journal ArticleDOI
Recombinant human interleukin 5 is a selective activator of human eosinophil function.
Angel F. Lopez,Colin J. Sanderson,Jennifer R. Gamble,Hugh Campbell,Ian G. Young,Mathew A. Vadas +5 more
TL;DR: Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils, and is thus a prime candidate for the selective eOSinophilia and eos inophil activation seen in disease.
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Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF.
TL;DR: RhIL-5 induced the greatest eosinophil production in liquid cultures, suggesting that although it may act on a smaller population of precursors, it is able to stimulate more proliferative steps than either rhIL-3 or rhGMCSF.
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Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor.
Yuji Yamaguchi,Y Hayashi,Y Sugama,Yasusada Miura,Tadashi Kasahara,S Kitamura,M Torisu,Seiji Mita,Akira Tominaga,Kiyoshi Takatsu +9 more
TL;DR: IL-5 is suggested to play an important role in increasing the functional activities of eosinophils as well as their production in allergic and parasitic diseases.
Journal ArticleDOI
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.
P R Burd,H. W. Rogers,John R. Gordon,C. A. Martin,Sundararajan Jayaraman,S D Wilson,Ann M. Dvorak,Stephen J. Galli,Martin E. Dorf +8 more
TL;DR: It is suggested that in addition to their inflammatory effector function mast cells may serve as a source of growth and regulatory factors.