Journal ArticleDOI
Interplay of replication checkpoints and repair proteins at stalled replication forks.
Dana Branzei,Marco Foiani +1 more
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TLDR
This review focuses mainly on the results obtained in budding yeast on the multiple roles of checkpoints in maintaining fork integrity and on the enzymatic activities that cooperate with the checkpoint pathway to promote fork resumption and repair of DNA lesions thereby contributing to genome integrity.About:
This article is published in DNA Repair.The article was published on 2007-07-01. It has received 144 citations till now. The article focuses on the topics: Control of chromosome duplication & DNA re-replication.read more
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DissertationDOI
S-phase checkpoint activity and function throughout the cell cycle
TL;DR: The Republic of Turkey Ministry of national education, the Raymond and Beverly Sackler Scholarships are awarded for outstanding contributions to the education of girls in Turkey.
Regulation of the DNA damage response by cyclin-dependent kinase in "Saccharomyces cerevisiae ”
TL;DR: In this article, the authors propose a method to solve the problem of "uniformity" and "uncertainty" in the context of broadcast broadcast, and it works well.
Journal ArticleDOI
The importance of nuclear RAGE–Mcm2 axis in diabetes or cancer-associated replication stress
Zhe Han,Martin Andrs,Bindhu Madhavan,Serap Kaymak,Alba Sulaj,Zoltan Kender,Stefan Kopf,Lars P. Kihm,Rainer Pepperkok,Pavel Janscak,Peter P. Nawroth,Varun Kumar +11 more
TL;DR: In this article , it was shown that RAGE deficiency leads to premature fork collapse, hypersensitivity to replication stress agents and reduction of viability, which was reversed by the reconstitution of RAGE.
References
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Journal ArticleDOI
RAD6 -dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
TL;DR: It is shown that UBC9, a small ubiquitin-related modifier (SUMO)-conjugating enzyme, is also affiliated with this pathway and that proliferating cell nuclear antigen (PCNA) is a substrate, and that damage-induced PCNA ubiquitination is elementary for DNA repair and occurs at the same conserved residue in yeast and humans.
Journal ArticleDOI
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques,James E. Haber +1 more
TL;DR: This review encompasses different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.
Journal ArticleDOI
The Bloom's syndrome helicase suppresses crossing over during homologous recombination
Leonard Wu,Ian D. Hickson +1 more
TL;DR: It is shown that mutations in BLM and hTOPO IIIα together effect the resolution of a recombination intermediate containing a double Holliday junction and prevents exchange of flanking sequences, which has wider implications for the understanding of the process of homologous recombination and the mechanisms that exist to prevent tumorigenesis.
Journal ArticleDOI
Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
TL;DR: The cellular response to DSBs and DNA replication stress is likely directed by the Mre11 complex detecting and processing DNA ends in conjunction with Sae2 and by RP-A recognizing single-stranded DNA and recruiting additional checkpoint and repair proteins.
Journal ArticleDOI
Replication Dynamics of the Yeast Genome
M. K. Raghuraman,Elizabeth A. Winzeler,David H. Collingwood,Sonia Y. Hunt,Lisa Wodicka,Andrew R. Conway,David J. Lockhart,Ronald W. Davis,Bonita J. Brewer,Walton L. Fangman +9 more
TL;DR: Oligonucleotide microarrays were used to map the detailed topography of chromosome replication in the budding yeast Saccharomyces cerevisiae, finding the two ends of each of the 16 chromosomes are highly correlated in their times of replication.
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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Lee Zou,Stephen J. Elledge +1 more