Journal ArticleDOI
Interplay of replication checkpoints and repair proteins at stalled replication forks.
Dana Branzei,Marco Foiani +1 more
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TLDR
This review focuses mainly on the results obtained in budding yeast on the multiple roles of checkpoints in maintaining fork integrity and on the enzymatic activities that cooperate with the checkpoint pathway to promote fork resumption and repair of DNA lesions thereby contributing to genome integrity.About:
This article is published in DNA Repair.The article was published on 2007-07-01. It has received 144 citations till now. The article focuses on the topics: Control of chromosome duplication & DNA re-replication.read more
Citations
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Journal ArticleDOI
An oncogene-induced DNA damage model for cancer development.
TL;DR: Oncogene-induced DNA damage may explain two key features of cancer: genomic instability and the high frequency of p53 mutations.
Journal ArticleDOI
The DNA Damage Response: Ten Years After
TL;DR: This work has witnessed an explosion in understanding of DNA damage sensing, signaling, and the complex interplay between protein phosphorylation and the ubiquitin pathway employed by the DDR network to execute the response to DNA damage.
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Mechanism of eukaryotic homologous recombination.
TL;DR: HR accessory factors that facilitate other stages of the Rad51- and Dmc1-catalyzed homologous DNA pairing and strand exchange reaction have also been identified.
Journal ArticleDOI
Regulation of DNA repair throughout the cell cycle
Dana Branzei,Marco Foiani +1 more
TL;DR: The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity and has provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases.
Journal ArticleDOI
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Eva Petermann,Manuel Luis Orta,Manuel Luis Orta,Natalia Issaeva,Niklas Schultz,Thomas Helleday,Thomas Helleday +6 more
TL;DR: The XRCC3 protein, which is required for RAD51 foci formation, is also required for replication restart of HU-stalled forks, suggesting that RAD51-mediated strand invasion supports fork restart.
References
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Journal ArticleDOI
CDC7/DBF4 Functions in the Translesion Synthesis Branch of the RAD6 Epistasis Group in Saccharomyces cerevisiae
TL;DR: It is proposed that the Cdc7-Dbf4 kinase associates with components of the translesion synthesis pathway and that this interaction is dependent upon the type of DNA damage, suggesting a direct role for CDC7 in DNA repair/damage tolerance.
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Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage.
Sonja Flott,John Rouse +1 more
TL;DR: Slx4 is revealed as a new target of the Mec1/Tel1 kinases, with a crucial role in DNA repair that is not restricted to the processing of stalled replisomes, in cells exposed to a wide range of genotoxins.
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Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.
TL;DR: It is proposed that Top3 functions in S phase to both process homologous recombination intermediates and modulate checkpoint activity.
Journal ArticleDOI
Eukaryotic DNA replication: a model for a fixed double replisome
TL;DR: A solution to the difficulty of separating the daughter molecules in an orderly way is suggested and an alternative to the current models is proposed, which reconciles the use of a single polarity of synthesis by the DNA polymerases with the need for parallel polymerization of two strands of opposite polarity.
Journal ArticleDOI
Abnormality in Initiation Program of DNA Replication Is Monitored by the Highly Repetitive rRNA Gene Array on Chromosome XII in Budding Yeast
Satoru Ide,Keiichi Watanabe,Hiromitsu Watanabe,Katsuhiko Shirahige,Takehiko Kobayashi,Hisaji Maki +5 more
TL;DR: It is reported that DNA lesions in the orc mutants are induced much more quickly and frequently within the rRNA gene (rDNA) locus than at other chromosomal loci upon temperature shift, suggesting that the rDNA locus primarily signals abnormalities in the initiation program to the DNA damage checkpoint and that the RDNA copy number modulates the sensitivity of this monitoring function.
Related Papers (5)
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Lee Zou,Stephen J. Elledge +1 more