Journal ArticleDOI
Interplay of replication checkpoints and repair proteins at stalled replication forks.
Dana Branzei,Marco Foiani +1 more
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TLDR
This review focuses mainly on the results obtained in budding yeast on the multiple roles of checkpoints in maintaining fork integrity and on the enzymatic activities that cooperate with the checkpoint pathway to promote fork resumption and repair of DNA lesions thereby contributing to genome integrity.About:
This article is published in DNA Repair.The article was published on 2007-07-01. It has received 144 citations till now. The article focuses on the topics: Control of chromosome duplication & DNA re-replication.read more
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Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
TL;DR: The mechanisms and impact of major sources of error in DNA replication, including loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process are reviewed.
Journal ArticleDOI
Replication Stress Leads to Genome Instabilities in Arabidopsis DNA Polymerase δ Mutants
TL;DR: The data suggest that efficient progression of DNA replication, foremost on the lagging strand, relies on the physiological level of the polymerase δ complex and that even a minor disturbance of the replication process critically threatens genomic integrity of Arabidopsis cells.
Journal ArticleDOI
Schizosaccharomyces pombe Histone Acetyltransferase Mst1 (KAT5) Is an Essential Protein Required for Damage Response and Chromosome Segregation
TL;DR: Schizosaccharomyces pombe (mst1) as mentioned in this paper is a member of the MYST family of histone acetyltransferases and is the likely ortholog of Esa1 and human Tip60 (KAT5).
Journal ArticleDOI
Genome Rearrangements Caused by Depletion of Essential DNA Replication Proteins in Saccharomyces cerevisiae
Edith Cheng,Jessica A. Vaisica,Jiongwen Ou,Anastasia Baryshnikova,Yong Lu,Frederick P. Roth,Frederick P. Roth,Grant W. Brown +7 more
TL;DR: A core set of 15 genes involved in DNA replication that are critical in preventing both spontaneous DNA damage and genome rearrangements are identified and a mechanisms by which depletion of essential replication proteins can lead to double-stranded DNA breaks near these features are proposed.
Journal ArticleDOI
ruvA and ruvB mutants specifically impaired for replication fork reversal
Marie Le Masson,Zeynep Baharoglu,Zeynep Baharoglu,Zeynep Baharoglu,Bénédicte Michel,Bénédicte Michel,Bénédicte Michel +6 more
TL;DR: The isolation and characterization of ruvA and ruvB single mutants that are impaired for RFR at forks arrested by the inactivation of polymerase III are presented, implying that RFR is a more demanding reaction than Holliday junction resolution.
References
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RAD6 -dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
TL;DR: It is shown that UBC9, a small ubiquitin-related modifier (SUMO)-conjugating enzyme, is also affiliated with this pathway and that proliferating cell nuclear antigen (PCNA) is a substrate, and that damage-induced PCNA ubiquitination is elementary for DNA repair and occurs at the same conserved residue in yeast and humans.
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Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques,James E. Haber +1 more
TL;DR: This review encompasses different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.
Journal ArticleDOI
The Bloom's syndrome helicase suppresses crossing over during homologous recombination
Leonard Wu,Ian D. Hickson +1 more
TL;DR: It is shown that mutations in BLM and hTOPO IIIα together effect the resolution of a recombination intermediate containing a double Holliday junction and prevents exchange of flanking sequences, which has wider implications for the understanding of the process of homologous recombination and the mechanisms that exist to prevent tumorigenesis.
Journal ArticleDOI
Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
TL;DR: The cellular response to DSBs and DNA replication stress is likely directed by the Mre11 complex detecting and processing DNA ends in conjunction with Sae2 and by RP-A recognizing single-stranded DNA and recruiting additional checkpoint and repair proteins.
Journal ArticleDOI
Replication Dynamics of the Yeast Genome
M. K. Raghuraman,Elizabeth A. Winzeler,David H. Collingwood,Sonia Y. Hunt,Lisa Wodicka,Andrew R. Conway,David J. Lockhart,Ronald W. Davis,Bonita J. Brewer,Walton L. Fangman +9 more
TL;DR: Oligonucleotide microarrays were used to map the detailed topography of chromosome replication in the budding yeast Saccharomyces cerevisiae, finding the two ends of each of the 16 chromosomes are highly correlated in their times of replication.
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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Lee Zou,Stephen J. Elledge +1 more