Journal ArticleDOI
Interplay of replication checkpoints and repair proteins at stalled replication forks.
Dana Branzei,Marco Foiani +1 more
Reads0
Chats0
TLDR
This review focuses mainly on the results obtained in budding yeast on the multiple roles of checkpoints in maintaining fork integrity and on the enzymatic activities that cooperate with the checkpoint pathway to promote fork resumption and repair of DNA lesions thereby contributing to genome integrity.About:
This article is published in DNA Repair.The article was published on 2007-07-01. It has received 144 citations till now. The article focuses on the topics: Control of chromosome duplication & DNA re-replication.read more
Citations
More filters
Book
Apoptosis: Physiology and Pathology
John C. Reed,Douglas R. Green +1 more
TL;DR: In this paper, the authors provide a timely compilation of reviews of mechanisms of apoptosis, with contributions from experts in the field, with a focus on organ-specific apoptosis-related diseases.
Journal ArticleDOI
UvrD and UvrD252 Counteract RecQ, RecJ, and RecFOR in a rep Mutant of Escherichia coli
Roxane Lestini,Bénédicte Michel +1 more
TL;DR: It is shown here that the synthetic lethality of rep and uvrD mutations is also suppressed by recQ and recJ inactivation but not by rarA inactivation, and these observations support the idea that UvrD counteracts a deleterious RecA binding to forks blocked in the rep mutant.
Book ChapterDOI
Homologous recombination in eukaryotes.
TL;DR: The players and mechanics of eukaryotic HR are reviewed and the importance of HR can be gauged by the conservation of HR genes and functions from bacteria to man.
Journal ArticleDOI
Maintaining replication fork integrity in UV-irradiated Escherichia coli cells
TL;DR: It is confirmed that RecFOR promote efficient reactivation of stalled forks and demonstrated that they are also needed for productive replication initiated at the origin, or triggered elsewhere by damage to the DNA.
References
More filters
Journal ArticleDOI
RAD6 -dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
TL;DR: It is shown that UBC9, a small ubiquitin-related modifier (SUMO)-conjugating enzyme, is also affiliated with this pathway and that proliferating cell nuclear antigen (PCNA) is a substrate, and that damage-induced PCNA ubiquitination is elementary for DNA repair and occurs at the same conserved residue in yeast and humans.
Journal ArticleDOI
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques,James E. Haber +1 more
TL;DR: This review encompasses different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.
Journal ArticleDOI
The Bloom's syndrome helicase suppresses crossing over during homologous recombination
Leonard Wu,Ian D. Hickson +1 more
TL;DR: It is shown that mutations in BLM and hTOPO IIIα together effect the resolution of a recombination intermediate containing a double Holliday junction and prevents exchange of flanking sequences, which has wider implications for the understanding of the process of homologous recombination and the mechanisms that exist to prevent tumorigenesis.
Journal ArticleDOI
Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
TL;DR: The cellular response to DSBs and DNA replication stress is likely directed by the Mre11 complex detecting and processing DNA ends in conjunction with Sae2 and by RP-A recognizing single-stranded DNA and recruiting additional checkpoint and repair proteins.
Journal ArticleDOI
Replication Dynamics of the Yeast Genome
M. K. Raghuraman,Elizabeth A. Winzeler,David H. Collingwood,Sonia Y. Hunt,Lisa Wodicka,Andrew R. Conway,David J. Lockhart,Ronald W. Davis,Bonita J. Brewer,Walton L. Fangman +9 more
TL;DR: Oligonucleotide microarrays were used to map the detailed topography of chromosome replication in the budding yeast Saccharomyces cerevisiae, finding the two ends of each of the 16 chromosomes are highly correlated in their times of replication.
Related Papers (5)
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Lee Zou,Stephen J. Elledge +1 more