Journal ArticleDOI
Interplay of replication checkpoints and repair proteins at stalled replication forks.
Dana Branzei,Marco Foiani +1 more
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TLDR
This review focuses mainly on the results obtained in budding yeast on the multiple roles of checkpoints in maintaining fork integrity and on the enzymatic activities that cooperate with the checkpoint pathway to promote fork resumption and repair of DNA lesions thereby contributing to genome integrity.About:
This article is published in DNA Repair.The article was published on 2007-07-01. It has received 144 citations till now. The article focuses on the topics: Control of chromosome duplication & DNA re-replication.read more
Citations
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Journal ArticleDOI
Can eukaryotic cells monitor the presence of unreplicated DNA
TL;DR: These results strongly suggest that normal yeast cells do not contain a DNA replication-completion checkpoint, and none of these checkpoints can monitor the presence of unreplicated segments or the unhindered progression of forks in rDNA.
Journal ArticleDOI
Down-regulation of Polη expression leads to increased DNA damage, apoptosis and enhanced S phase arrest in L-02 cells exposed to hydroquinone
Gonghua Hu,Haiyan Huang,Lingqing Yang,Caigao Zhong,Bo Xia,Yuan Yang,Jianjun Liu,Desheng Wu,Qingchen Liu,Zhixiong Zhuang,Zhixiong Zhuang +10 more
TL;DR: Polη plays an important role in the response of L-02 cells to HQ-induced DNA damage, and knockdown of Polη resulted in more enhanced apoptosis and more pronounced S phase arrest following HQ treatment.
Journal ArticleDOI
INO80 meets a fork in the road.
Kelly M. Trujillo,Mary Ann Osley +1 more
TL;DR: A study finds that the INO80 complex is essential for replication fork progression under conditions of replicative stress, stabilizes stalled forks and helps ensure proper restart.
Journal ArticleDOI
Non-radioisotope method for diagnosing photosensitive genodermatoses and a new marker for xeroderma pigmentosum variant.
TL;DR: The non‐radioisotope method and the new marker described here comprise an easy way to diagnose XP and CS and discovered a new useful marker for XP variant based on checkpoint activity.
Dissertation
Characterization and Quantification of Poly(ADP-Ribose) in Cells and Tissues by Isotope Dilution Mass Spectrometry
TL;DR: A sensitive, precise and accurate bioanalytical method, based on chromatography-coupled isotope-dilution tandem mass spectrometry, to characterize and quantify PAR with femtomol sensitivity and unequivocal chemical selectivity will be instrumental for in-depth investigations on the metabolism of poly(ADP-ribosyl)ation.
References
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Journal ArticleDOI
RAD6 -dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
TL;DR: It is shown that UBC9, a small ubiquitin-related modifier (SUMO)-conjugating enzyme, is also affiliated with this pathway and that proliferating cell nuclear antigen (PCNA) is a substrate, and that damage-induced PCNA ubiquitination is elementary for DNA repair and occurs at the same conserved residue in yeast and humans.
Journal ArticleDOI
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques,James E. Haber +1 more
TL;DR: This review encompasses different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.
Journal ArticleDOI
The Bloom's syndrome helicase suppresses crossing over during homologous recombination
Leonard Wu,Ian D. Hickson +1 more
TL;DR: It is shown that mutations in BLM and hTOPO IIIα together effect the resolution of a recombination intermediate containing a double Holliday junction and prevents exchange of flanking sequences, which has wider implications for the understanding of the process of homologous recombination and the mechanisms that exist to prevent tumorigenesis.
Journal ArticleDOI
Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
TL;DR: The cellular response to DSBs and DNA replication stress is likely directed by the Mre11 complex detecting and processing DNA ends in conjunction with Sae2 and by RP-A recognizing single-stranded DNA and recruiting additional checkpoint and repair proteins.
Journal ArticleDOI
Replication Dynamics of the Yeast Genome
M. K. Raghuraman,Elizabeth A. Winzeler,David H. Collingwood,Sonia Y. Hunt,Lisa Wodicka,Andrew R. Conway,David J. Lockhart,Ronald W. Davis,Bonita J. Brewer,Walton L. Fangman +9 more
TL;DR: Oligonucleotide microarrays were used to map the detailed topography of chromosome replication in the budding yeast Saccharomyces cerevisiae, finding the two ends of each of the 16 chromosomes are highly correlated in their times of replication.
Related Papers (5)
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Lee Zou,Stephen J. Elledge +1 more