Journal ArticleDOI
Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: a study in mice.
TLDR
It is concluded that pre-treatment with astaxanthin attenuates cyclophosphamide-induced oxidative stress and subsequent DNA damage in mice and it can be used as a chemoprotective agent against the toxicity of anticancer drug cycloph phosphamide.About:
This article is published in Chemico-Biological Interactions.The article was published on 2009-08-14. It has received 125 citations till now. The article focuses on the topics: Comet assay & Oxidative stress.read more
Citations
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Oxidative stress in bone remodelling and disease.
TL;DR: The crucial role of oxidative stress in bone pathophysiology is reviewed, and the possibility that ROS production might be a relevant therapeutic target under certain conditions is discussed, to investigate whether manipulation of the redox balance in bone cells represents a useful approach in the design of future therapies for bone diseases.
Journal ArticleDOI
Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review.
TL;DR: A range of potential mechanisms through which astaxanthin might exert its benefits on skin homeostasis have been proposed, including photoprotective, antioxidant, and anti-inflammatory effects.
Journal ArticleDOI
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
Lynnette R. Ferguson,Helen Chen,Andrew Collins,Marisa Connell,Giovanna Damia,Santanu Dasgupta,Meenakshi Malhotra,Alan K. Meeker,Amedeo Amedei,Amr Amin,Amr Amin,S. Salman Ashraf,Katia Aquilano,Asfar S. Azmi,Dipita Bhakta,Alan Bilsland,Chandra S. Boosani,Sophie Chen,Maria Rosa Ciriolo,Hiromasa Fujii,Gunjan Guha,Dorota Halicka,William G. Helferich,W. Nicol Keith,Sulma I. Mohammed,Elena Niccolai,Xujuan Yang,Kanya Honoki,Virginia R. Parslow,Satya Prakash,Sarallah Rezazadeh,Rodney E. Shackelford,David Sidransky,Phuoc T. Tran,Eddy S. Yang,Christopher A. Maxwell +35 more
TL;DR: Vitamin D and B, selenium, carotenoids, PARP inhibitors, resveratrol, and isothiocyanates are highlighted as priority approaches against genomic instability.
Journal ArticleDOI
Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases.
Haijian Wu,Huanjiang Niu,Anwen Shao,Cheng Wu,Brandon Dixon,Jianmin Zhang,Shuxu Yang,Yirong Wang +7 more
TL;DR: There is evidence demonstrating that astaxanthin confers neuroprotective effects in experimental models of acute injuries, chronic neurodegenerative disorders, and neurological diseases.
Journal ArticleDOI
Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: role of Nrf2, p53, p38 and phase-II enzymes.
TL;DR: Astaxanthin is a potent antioxidant and attenuates oxidative stress, DNA damage, cell death as well as induction of early hepatocarcinogenesis in rat induced by cyclophosphamide, providing the evidence that one of the mechanism of chemoprotection offered by astaxanth in is mediated through Nrf2-ARE pathway.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
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A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
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Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.
TL;DR: The activities of some glutathione-metabolizing enzymes were observed to be 5-to 60-fold lower in lung tissue than in the liver, and that phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutATHione in lung and liver.