Journal ArticleDOI
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.
TLDR
These findings provide the first direct and definitive evidence of a deeply but reversibly quiescent subpopulation of leukemic cells in patients with CML with both in vitro and in vivo stem cell properties.About:
This article is published in Blood.The article was published on 1999-09-15. It has received 490 citations till now. The article focuses on the topics: Progenitor cell & Interleukin 3.read more
Citations
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Journal ArticleDOI
Cancer Stem Cells
TL;DR: This review describes cancer stem cells, a topic of considerable biologic and clinical interest in oncology.
Journal ArticleDOI
Hematopoietic stem cell quiescence maintained by p21cip1/waf1.
Tao Cheng,Neil P. Rodrigues,Hongmei Shen,Yong-Guang Yang,David Dombkowski,Megan Sykes,David T. Scadden +6 more
TL;DR: P21 is the molecular switch governing the entry of stem cells into the cell cycle, and in its absence, increased cell cycling leads to stem cell exhaustion, and under conditions of stress, restricted cell cycling is crucial to prevent premature stem cell depletion and hematopoietic death.
Journal ArticleDOI
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
Susan M. Graham,Heather G. Jørgensen,Elaine K. Allan,Charlie Pearson,Michael J. Alcorn,Linda Richmond,Tessa L. Holyoake +6 more
TL;DR: In vitro insensitivity to STI571, in combination with its demonstrated antiproliferative activity, could translate into disease relapse after prolonged therapy despite dramatic short-term responses in vivo.
Journal ArticleDOI
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
Bin-Bing S. Zhou,Haiying Zhang,Marc Damelin,Kenneth G. Geles,Justin C. Grindley,Peter B. Dirks +5 more
TL;DR: This Review considers recent advances in the cancer stem cell field, focusing on the challenges and opportunities for anticancer drug discovery.
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Dynamics of chronic myeloid leukaemia.
Franziska Michor,Timothy P. Hughes,Yoh Iwasa,Susan Branford,Neil P. Shah,Charles L. Sawyers,Charles L. Sawyers,Martin A. Nowak +7 more
TL;DR: A four-compartment model, based on the known biology of haematopoietic differentiation, can explain the kinetics of the molecular response to imatinib in a 169-patient data set and provides the first quantitative insights into the in vivoKinetics of a human cancer.
References
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Journal ArticleDOI
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
TL;DR: An unsuspected abnormality in all cells from the nine patients with chronic myelogenous leukaemia has been detected with quinacrine fluorescence and various Giemsa staining techniques, suggesting that there may be a hitherto undetected translocation between the long arm of 22 and thelong arm of 9, producing the 9q+ chromosome.
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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
TL;DR: The highly specific presence of a chromosomal breakpoint within bcr within Ph'-positive CML patients strongly suggests the involvement of bcr in this type of leukemia.
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Differentiation and Proliferation of Hematopoietic Stem Cells
TL;DR: This simple model fits the understanding of the interactions of growth factors with hematopoietic progenitors and risks oversimplification of a very complex process.
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Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
TL;DR: Detailed flow cytometric analysis of the marrow of highly engrafted mice demonstrated both lymphoid and myeloid differentiation, as well as the retention of a significant fraction of CD34(+) CD38(-) cells, which should be useful for identification of the cellular and molecular mechanisms that regulate primitive human hematopoietic cells.
Related Papers (5)
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more