Journal ArticleDOI
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.
TLDR
These findings provide the first direct and definitive evidence of a deeply but reversibly quiescent subpopulation of leukemic cells in patients with CML with both in vitro and in vivo stem cell properties.About:
This article is published in Blood.The article was published on 1999-09-15. It has received 490 citations till now. The article focuses on the topics: Progenitor cell & Interleukin 3.read more
Citations
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Journal ArticleDOI
Regulation of self-renewal in normal and cancer stem cells
TL;DR: Differences in mode of division, cell‐cycle properties, replicative potential and handling of DNA damage, in addition to the activation/inactivation of cancer‐specific molecular pathways confer on cancer stem cells a malignant phenotype.
Book ChapterDOI
High-Dimensional Single-Cell Cancer Biology
Jonathan M. Irish,Deon B. Doxie +1 more
TL;DR: Flow cytometry techniques that enable a "single-cell " view of cancer are described and are critical to optimizing the next generation of cancer treatments combining targeted approaches and immunotherapy.
Journal ArticleDOI
Role of STAT3 in Transformation and Drug Resistance in CML.
TL;DR: JAK/STAT3 is an attractive therapeutic target for developing strategies for targeting the JAK–STAT3 pathway in combination with bcr–abl kinase inhibitors and may represent a viable strategy for eliminating or reducing minimal residual disease located in the BM in CML.
Journal ArticleDOI
Biology of BCR-ABL
TL;DR: This retrovirus was isolated from a pred-nisolone treated mouse which developed lymphomafollowing innoculation with Moloney murineleukaemia virus (M-MuLV).
Journal ArticleDOI
Pathobiology of lymphoid and myeloid blast crisis and management issues.
TL;DR: The effect of imatinib on primitive CML progenitors and how this might influence the pathophysiology of blast crisis are examined and a rational framework for deciding how best to integrate stem cell transplantation, traditional chemotherapy,Imatinib, and other BCR-ABL kinase inhibitors in the care ofblast crisis patients are discussed.
References
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Journal ArticleDOI
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
TL;DR: An unsuspected abnormality in all cells from the nine patients with chronic myelogenous leukaemia has been detected with quinacrine fluorescence and various Giemsa staining techniques, suggesting that there may be a hitherto undetected translocation between the long arm of 22 and thelong arm of 9, producing the 9q+ chromosome.
Journal ArticleDOI
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
TL;DR: The highly specific presence of a chromosomal breakpoint within bcr within Ph'-positive CML patients strongly suggests the involvement of bcr in this type of leukemia.
Journal ArticleDOI
Differentiation and Proliferation of Hematopoietic Stem Cells
TL;DR: This simple model fits the understanding of the interactions of growth factors with hematopoietic progenitors and risks oversimplification of a very complex process.
Journal ArticleDOI
Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
TL;DR: Detailed flow cytometric analysis of the marrow of highly engrafted mice demonstrated both lymphoid and myeloid differentiation, as well as the retention of a significant fraction of CD34(+) CD38(-) cells, which should be useful for identification of the cellular and molecular mechanisms that regulate primitive human hematopoietic cells.
Related Papers (5)
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more