Journal ArticleDOI
Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis.
Ming Cheng,Ding Liqin,Hongfeng Kan,Hongmin Zhang,Benke Jiang,Benke Jiang,Yingjie Sun,Cao Shijie,Wei Li,Wei Li,Kazuo Koike,Feng Qiu +11 more
TLDR
Two new flavonoid glycosides were isolated from the 75% EtOH extract of the dried roots of Glycyrrhiza uralensis Fisch and evaluated for in vitro hepatoprotective activity against d-galactosamine-induced toxicity in human hepatoma HepG2 cells.Abstract:
Two new flavonoid glycosides, 2′,4′-dihydroxydihydrochalcone-4-O-β-d-glucopyranoside (1) and medicarpin-3-O-β-d-apiofuranosyl (1 → 2)-β-d-glucopyranoside (2), together with 34 known flavonoids were isolated from the 75% EtOH extract of the dried roots of Glycyrrhiza uralensis Fisch. Their structures were elucidated on the basis of spectroscopic analyses. The flavonoids were classified into ten sub-types, namely, dihydrochalcone (1), pterocarpans (2–4), flavones (5–6), flavanones (7–11), chalcones (12–15), retro-chalcones (16–18), isoflavans (19–21), isoflavones (22–28), 3-arylcoumarins (29–30), and coumestans (31–36). The isolated flavonoids were evaluated for in vitro hepatoprotective activity against d-galactosamine-induced toxicity in human hepatoma HepG2 cells.read more
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Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics
Mithun Rudrapal,Johra Khan,Abdul Aziz Bin Dukhyil,Randa Mohammed Ibrahim Ismail Alarousy,Emmanuel Ifeanyi Attah,Tripti Sharma,Shubham Jagdish Khairnar,Atul R. Bendale +7 more
TL;DR: Chalcones are secondary metabolites belonging to the C6-C3-C6 system as mentioned in this paper that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids.
Journal ArticleDOI
Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological and Health-Promoting Abilities.
Javad Sharifi-Rad,Cristina Quispe,Jesús Herrera-Bravo,Jesús Herrera-Bravo,Lisandra Herrera Belén,Rajandeep Kaur,Dorota Kregiel,Yadav Uprety,Ahmet Beyatli,Balakyz Yeskaliyeva,Celale Kirkin,Beraat Özçelik,Surjit Sen,Krishnendu Acharya,Farukh Sharopov,Natália Cruz-Martins,Manoj Kumar,Ahmad Faizal Abdull Razis,Usman Sunusi,Usman Sunusi,Ramla Muhammad Kamal,Shabnum Shaheen,Hafiz Ansar Rasul Suleria +22 more
TL;DR: A review of the most widely investigated Glycyrrhiza species for food and medicinal purposes, with special emphasis on secondary metabolites' composition and bioactive effects, is provided in this paper.
Journal ArticleDOI
Dihydrochalcones: Methods of Acquisition and Pharmacological Properties—A First Systematic Review
TL;DR: This review aims at analyzing and summarizing the methods of obtaining dihydrochalcones and of presenting their pharmacological actions that have been described in the literature to support potential future development of this group of compounds as novel therapeutic drugs.
Journal ArticleDOI
Natural Chalcones in Chinese Materia Medica: Licorice.
TL;DR: This review aims to summarize structures and biological activities of chalcones from licorice, and it is hoped that this work can provide a theoretical basis for the further studies of Chalcone from Licorice.
Journal ArticleDOI
Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation.
Lisard Iglesias-Carres,Michael Hughes,Cortney N. Steele,Monica A. Ponder,Kevin P. Davy,Andrew P. Neilson +5 more
TL;DR: In this paper, a review of the use of phytochemicals as TMAO-reducing agents is presented, which discusses the main mechanisms by which Trimethylamine-N-oxide (TMAO) promotes CVD, including modulation of lipid and bile acid metabolism, and the promotion of endothelial dysfunction and oxidative stress.
References
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Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)
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