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Leptospira and leptospirosis.
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The article was published on 2015-01-01 and is currently open access. It has received 1720 citations till now. The article focuses on the topics: Leptospira & Leptospirosis.read more
Citations
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Journal ArticleDOI
Global Morbidity and Mortality of Leptospirosis: A Systematic Review.
Federico Costa,José E. Hagan,Juan Ignacio Calcagno,Michael J. Kane,Paul R. Torgerson,Martha Sílvia Martinez-Silveira,Claudia Stein,Bernadette Abela-Ridder,Albert I. Ko,Albert I. Ko +9 more
TL;DR: Leptospirosis is among the leading zoonotic causes of morbidity worldwide and accounts for numbers of deaths, which approach or exceed those for other causes of haemorrhagic fever.
Book ChapterDOI
Leptospirosis in Humans
David A. Haake,Paul N. Levett +1 more
TL;DR: Data emerging from prospective surveillance studies suggest that most human leptospiral infections in endemic areas are mild or asymptomatic, and patients progressing to multisystem organ failure have widespread hematogenous dissemination of pathogens.
Journal ArticleDOI
Leptospira : the dawn of the molecular genetics era for an emerging zoonotic pathogen
TL;DR: The life cycle of the bacterium, the recent advances in understanding and the implications for the future prevention of leptospirosis are discussed.
Journal ArticleDOI
Climate change, flooding, urbanisation and leptospirosis: fuelling the fire?
TL;DR: Mechanisms by which climate change can affect various ecological factors that are likely to drive an increase in the overall incidence as well as the frequency of outbreaks of leptospirosis are examined.
Journal ArticleDOI
Leptospirosis in the Asia Pacific region
Ann Florence B. Victoriano,Lee D. Smythe,Nina Gloriani-Barzaga,Lolita L Cavinta,Takeshi Kasai,Khanchit Limpakarnjanarat,Bee Lee Ong,Gyanendra Gongal,Julie Lyn Hall,Caroline Anne Coulombe,Yasutake Yanagihara,Shin-ichi Yoshida,Ben Adler +12 more
TL;DR: In the Asia Pacific region, predominantly in developing countries, leptospirosis is largely a water-borne disease and unless interventions to minimize exposure are aggressively implemented, the current global climate change will further aggravate the extent of the disease problem.
References
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Journal ArticleDOI
Leptospirosis: a zoonotic disease of global importance
Ajay R. Bharti,Jarlath E. Nally,Jessica N. Ricaldi,Michael A. Matthias,Monica M. Diaz,Michael A. Lovett,Paul N. Levett,Robert H. Gilman,Michael R. Willig,Eduardo Gotuzzo,Joseph M. Vinetz +10 more
TL;DR: The completion of the genome sequence of Leptospira interrogans serovar lai, and other continuing leptospiral genome sequencing projects, promise to guide future work on the disease.
Journal ArticleDOI
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.
Catherine Werts,Catherine Werts,Richard I. Tapping,John C. Mathison,Tsung-Hsien Chuang,Vladimir V. Kravchenko,Isabelle Saint Girons,David A. Haake,Paul J. Godowski,Fumitaka Hayashi,Adrian Ozinsky,David M. Underhill,Carsten J. Kirschning,Hermann Wagner,Alan Aderem,Peter S. Tobias,Richard J. Ulevitch +16 more
TL;DR: It is shown that for intact L. interrogans, it is LPS, not lipoprotein, that constitutes the predominant signaling component for macrophages through a TLR2 pathway, providing a basis for understanding the innate immune response caused by leptospirosis.
Journal ArticleDOI
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Shuang-Xi Ren,Shuang-Xi Ren,Gang Fu,Xiu-Gao Jiang,Rong Zeng,You-Gang Miao,Hai Xu,Yi-Xuan Zhang,Hui Xiong,Gang Lu,Ling-Feng Lu,Hong-Quan Jiang,Jia Jia,Yuefeng Tu,Ju-Xing Jiang,Wenyi Gu,Yue-Qing Zhang,Yue-Qing Zhang,Zhen Cai,Haihui Sheng,Hai-Feng Yin,Yi Zhang,Genfeng Zhu,Ma Wan,Hong-Lei Huang,Zhen Qian,Shengyue Wang,Wei Ma,Zhijian Yao,Yan Shen,Boqin Qiang,Qi-Chang Xia,Xiaokui Guo,Antoine Danchin,Isabelle Saint Girons,Ronald L. Somerville,Yu-Mei Wen,Man-Hua Shi,Zhu Chen,Jianguo Xu,Guoping Zhao,Guoping Zhao +41 more
TL;DR: The complete genomic sequence of a representative virulent serovar type strain (Lai) of Leptospira interrogans serogroup Icterohaemorrhagiae is reported, consisting of a 4.33-megabase large chromosome and a 359-kilobase small chromosome, with a total of 4,768 predicted genes.
Journal ArticleDOI
Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
Ana L. T. O. Nascimento,Albert I. Ko,Albert I. Ko,Elizabeth A. L. Martins,Claudia Barros Monteiro-Vitorello,Paulo L. Ho,David A. Haake,David A. Haake,Sergio Verjovski-Almeida,Rudy A. Hartskeerl,Marilis V. Marques,Mariana Cabral de Oliveira,Carlos Frederico Martins Menck,Luciana C. C. Leite,Helaine Carrer,Luiz Lehmann Coutinho,Wim Degrave,Odir Antônio Dellagostin,Hamza El-Dorry,Emer S. Ferro,Maria Inês Tiraboschi Ferro,Luiz Roberto Furlan,Marcia Gamberini,E. A. Giglioti,Aristóteles Góes-Neto,Gustavo H. Goldman,Maria Helena S. Goldman,Ricardo Harakava,Selma M. B. Jeronimo,Inácio L.M. Junqueira-de-Azevedo,Edna Teruko Kimura,Eiko E. Kuramae,Eliana Gertrudes de Macedo Lemos,Manoel Victor Franco Lemos,Celso Luis Marino,Luiz R. Nunes,R. C. de Oliveira,Gonçalo A.G. Pereira,Marcelo S. Reis,A. Schriefer,Walter José Siqueira,P. Sommer,Siu Mui Tsai,Andrew J. G. Simpson,Jesus Aparecido Ferro,Luis Eduardo Aranha Camargo,João Paulo Kitajima,João C. Setubal,M. A. Van Sluys +48 more
TL;DR: Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis.