Journal ArticleDOI
Life expectancy and cardiovascular mortality in persons with schizophrenia.
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TLDR
Schizophrenia is associated with a substantially higher mortality and curtailed life expectancy partly caused by modifiable risk factors, including unhealthy diets, excessive smoking and alcohol use, and lack of exercise.Abstract:
Purpose of reviewTo assess the impact of cardiovascular disease on the excess mortality and shortened life expectancy in schizophrenic patients.Recent findingsPatients with schizophrenia have two-fold to three-fold higher mortality rates compared with the general population, corresponding to a 10–25read more
Citations
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Journal ArticleDOI
Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis.
Carsten Hjorthøj,Carsten Hjorthøj,Anne Emilie Stürup,John J. McGrath,John J. McGrath,John J. McGrath,Merete Nordentoft,Merete Nordentoft +7 more
TL;DR: The effects of schizophrenia on years potential life lost and life expectancy seem to be substantial and not to have lessened over time, and development and implementation of interventions and initiatives to reduce this mortality gap are urgently needed.
Journal ArticleDOI
Excess Early Mortality in Schizophrenia
TL;DR: The most urgent research agenda concerns primary candidates for modifiable risk factors contributing to this excess mortality, i.e., side effects of treatment and lifestyle factors, as well as sufficient prevention and treatment of physical comorbidity.
Journal ArticleDOI
Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder
TL;DR: To what degree medication‐specific and patient‐specific risk factors interact, and how adverse outcomes can be minimized, allowing patients to derive maximum benefits from these medications, requires adequate clinical attention and further research.
Journal ArticleDOI
Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study.
TL;DR: Schizophrenia patients had markedly premature mortality, and the leading causes were ischemic heart disease and cancer, which appeared to be underdiagnosed.
Journal ArticleDOI
Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors
Ole A. Andreassen,Ole A. Andreassen,Ole A. Andreassen,Srdjan Djurovic,Srdjan Djurovic,Wesley K. Thompson,Andrew J. Schork,Kenneth S. Kendler,Michael Conlon O'Donovan,Dan Rujescu,Thomas Werge,Martijn van de Bunt,Andrew P. Morris,Mark I. McCarthy,J. Cooper Roddey,Linda K. McEvoy,Rahul S. Desikan,Anders M. Dale +17 more
TL;DR: A genetic-pleiotropy-informed method for improving gene discovery with the use of GWAS summary-statistics data and enrichment of SNPs associated with schizophrenia (SCZ) as a function of the association with several CVD risk factors and a corresponding reduction in false discovery rate is presented.
References
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Journal ArticleDOI
A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?
TL;DR: In light of the potential for second-generation antipsychotic medications to further adversely influence mortality rates in the decades to come, optimizing the general health of people with schizophrenia warrants urgent attention.
Journal ArticleDOI
Excess mortality of mental disorder.
E C Harris,B Barraclough +1 more
TL;DR: All mental disorders have an increased risk of premature death, and risk of death from unnatural causes is especially high for the functional disorders, particularly schizophrenia and major depression.
Journal ArticleDOI
Schizophrenia and increased risks of cardiovascular disease.
Charles H. Hennekens,Charles H. Hennekens,Alissa R. Hennekens,Danielle Hollar,Danielle Hollar,Daniel E. Casey +5 more
TL;DR: The chief cause of excess premature mortality among patients with schizophrenia is CHD, caused mainly by their adverse risk factor profile, which is cigarette smoking, obesity leading to dyslipidemia, insulin resistance and diabetes, and hypertension.
Journal ArticleDOI
Mortality and causes of death in schizophrenia in Stockholm county, Sweden.
TL;DR: Overall and cause-specific standardized mortality ratios (SMR) in suicide were especially high in young patients in the first year after the first diagnosis of schizophrenia, and increased in both natural and unnatural causes of death.
Journal ArticleDOI
Life Expectancy at Birth for People with Serious Mental Illness and Other Major Disorders from a Secondary Mental Health Care Case Register in London
Chin-Kuo Chang,Richard D. Hayes,Gayan Perera,M. Broadbent,Andrea C Fernandes,William Lee,Matthew Hotopf,Robert Stewart +7 more
TL;DR: The impact of serious mental illness on life expectancy is marked and generally higher than similarly calculated impacts of well-recognised adverse exposures such as smoking, diabetes and obesity.