Journal ArticleDOI
Lineage-specific laminar organization of cortical GABAergic interneurons
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TLDR
It is reported that cortical interneurons labeled at the clonal level do not distribute randomly but rather have a strong tendency to cluster in the mouse neocortex, which challenges current views of cortical neurogenesis.Abstract:
In the cerebral cortex, pyramidal cells and interneurons are generated in distant germinal zones, and so the mechanisms that control their precise assembly into specific microcircuits remain an enigma. Here we report that cortical interneurons labeled at the clonal level do not distribute randomly but rather have a strong tendency to cluster in the mouse neocortex. This behavior is common to different classes of interneurons, independently of their origin. Interneuron clusters are typically contained within one or two adjacent cortical layers, are largely formed by isochronically generated neurons and populate specific layers, as revealed by unbiased hierarchical clustering methods. Our results suggest that different progenitor cells give rise to interneurons populating infra- and supragranular cortical layers, which challenges current views of cortical neurogenesis. Thus, specific lineages of cortical interneurons seem to be produced to primarily mirror the laminar structure of the cerebral cortex, rather than its columnar organization.read more
Citations
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Interneuron cell types are fit to function
Adam Kepecs,Gordon Fishell +1 more
TL;DR: This perspective emphasizes that the ultimate goal is to dispense with classification criteria and directly define interneuron types by function, and views them as elaborations of a much more finite group of developmentally specified cardinal classes that become further specialized as they mature.
Journal ArticleDOI
Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
Journal ArticleDOI
Development and Functional Diversification of Cortical Interneurons
TL;DR: An overview of the mechanisms underlying the generation of the distinct types of interneurons and their integration in cortical circuits is provided.
Journal ArticleDOI
Generating neuronal diversity in the mammalian cerebral cortex.
Simona Lodato,Paola Arlotta +1 more
TL;DR: The structural blueprint of the neocortex is broadly reviewed and the current classification of its neuronal diversity is discussed, which covers the principles and mechanisms that build neuronal diversity during cortical development and the impact of neuronal class-specific identity in shaping cortical connectivity and function.
Journal ArticleDOI
Genetic and activity-dependent mechanisms underlying interneuron diversity
Brie Wamsley,Gord Fishell +1 more
TL;DR: A wealth of recent findings are discussed that have advanced the understanding of the developmental mechanisms that contribute to the diversification of interneurons and suggest areas of particular promise for further investigation.
References
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Journal ArticleDOI
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