Journal ArticleDOI
Lipid emulsion enhances fish allergen parvalbumin's resistance to in vitro digestion and IgG/IgE binding capacity.
Chen Luo,Yuman Guo,Zhenxing Li,Ishfaq Ahmed,Siddanakoppalu N. Pramod,Xiang Gao,Liangtao Lv,Hong Lin +7 more
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TLDR
Lipid emulsion decreased the digestive ability of PV in stomach, increasing resistance to gastrointestinal digestion by pepsin proteases and altered IgG/IgEbinding ability of digestion products, thereby indicating that PV with lipid emulsion was resistant to digestion and possessed increased IgE binding ability resulting in higher risk of allergy among sensitized individuals.About:
This article is published in Food Chemistry.The article was published on 2020-01-01. It has received 20 citations till now. The article focuses on the topics: Protein digestion & Immunoglobulin G.read more
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Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens
Joana Costa,Caterina Villa,Kitty C.M. Verhoeckx,Tanja Cirkovic-Velickovic,Tanja Cirkovic-Velickovic,Denise Schrama,Paola Roncada,Pedro M. Rodrigues,Cristian Piras,Cristian Piras,Laura Martín-Pedraza,Linda Monaci,Elena Molina,Gabriel Mazzucchelli,Isabel Mafra,Roberta Lupi,Daniel Lozano-Ojalvo,Colette Larré,Julia Klueber,Eva Gelencser,Cristina Bueno-Díaz,Araceli Díaz-Perales,Sara Benedé,Simona L. Bavaro,Simona L. Bavaro,Annette Kuehn,Karin Hoffmann-Sommergruber,Thomas Holzhauser +27 more
TL;DR: The authors' extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family, although it fails to explain the potency of some unstable allergens.
Journal ArticleDOI
Abundance and Stability as Common Properties of Allergens
TL;DR: In this paper, the authors focus on recent studies which examine two such factors: abundance and stability, and conclude that changes in protein stability can predictably alter gastric/endosomal processing and immunogenicity.
Journal ArticleDOI
Tyrosinase/caffeic acid cross-linking alleviated shrimp (Metapenaeus ensis) tropomyosin-induced allergic responses by modulating the Th1/Th2 immunobalance.
Ishfaq Ahmed,Hong Lin,Zhenxing Li,Lili Xu,Ihsan Mabood Qazi,Chen Luo,Xiang Gao,Mati Ullah Khan,Amjad Iqbal,Yuman Guo,Tushar Ramesh Pavase,Lirui Sun +11 more
TL;DR: TM-Tyr/CA showed reduced allergenicity and may have preventive effect in relieving TM induced allergic response via immunosuppression and positive modulation of T-helper (Th)1/Th2 immunobalance.
Journal ArticleDOI
Natural Shrimp (Litopenaeus vannamei) Tropomyosin Shows Higher Allergic Properties than Recombinant Ones as Compared through SWATH-MS-Based Proteomics and Immunological Response.
TL;DR: Findings would supply foundation data for epitope-based immunotherapy to shrimp allergic individuals and show that pepsin-digested and trypsin-Digested samples of rTM exhibited lower IgG-/IgE binding and degranulation than those of nTM.
Journal ArticleDOI
Gastrointestinal fate of food allergens and its relationship with allergenicity.
TL;DR: This review presents in detail digestion models for predicting allergenicity, the fates of food allergens in oral, gastric and duodenal digestion, and the applications of digestomics in mapping IgE-binding epitopes of digestion-resistant peptides.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
A standardised static in vitro digestion method suitable for food – an international consensus
Mans Minekus,Marie Alminger,Paula Alvito,Simon Ballance,Torsten Bohn,Claire Bourlieu,Claire Bourlieu,Frédéric Carrière,Rachel Boutrou,Rachel Boutrou,Milena Corredig,Didier Dupont,Didier Dupont,Claire Dufour,Lotti Egger,Matt Golding,Sibel Karakaya,Bente Kirkhus,S. Le Feunteun,Uri Lesmes,Adam Macierzanka,Alan R. Mackie,Sébastien Marze,David Julian McClements,Olivia Ménard,Olivia Ménard,Isidra Recio,Cláudia N. Santos,Rajat Singh,Gerd E. Vegarud,Martin S. J. Wickham,Werner Weitschies,André Brodkorb +32 more
TL;DR: In this article, the authors proposed a general standardised and practical static digestion method based on physiologically relevant conditions that can be applied for various endpoints, which may be amended to accommodate further specific requirements.
Journal ArticleDOI
Molecular properties of food allergens
TL;DR: Although the authors cannot as yet predict the allergenicity of a given food protein, understanding of the molecular properties that might predispose them to becoming allergens is an important first step and will undoubtedly contribute to the integrative allergenic risk assessment process being adopted by regulators.
Journal ArticleDOI
Food protein functionality: A comprehensive approach
TL;DR: This review will focus on integrating the colloidal/polymer and biological aspects of protein functionality using foams and gels to illustrate colloidal-polymer aspects and bioactive peptides and allergenicity to demonstrate biological function.