Long-term protection of HPV test in women at risk of cervical cancer.
Raquel Ibáñez,Esther Roura,Laura Monfil,Luís Alejandro Rodríguez,Montserrat Sardà,Nayade Crespo,Amparo Pascual,Clara Martí,Montserrat Fibla,Cristina Gutierrez,Belen Lloveras,Glòria Oliveras,Anna Torrent,Isabel Català,Francesc Bosch,Laia Bruni,Silvia de Sanjosé +16 more
TLDR
HPV detection shows a high longitudinal predictive value at 9-year to identify women at risk to develop CIN2+.Abstract:
OBJECTIVE: To evaluate the 9-year incidence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and cumulative adherence to perform a next test in a cohort of women aged 40+ years with no cervical screening cytology within a window of 5 years (underscreened women), after baseline cervical cytology and HPV tests. METHODS: In Catalonia, Spain, co-testing with cytology and HPV test has been recommended in the Public Health system since 2006 for underscreened women. In 2007, 1,594 women with underscreened criteria were identified and followed through medical records form Pathological Department. 9-year cumulative incidence of histologically confirmed CIN2+ and cumulative adherence to perform a next test were estimated using Kaplan-Meier statistics. RESULTS: Follow-up was available for 1,009 women (63.3%) resulting in 23 women with. CIN2+ (2.3%). Of them, 4 women (17%) had both tests negative at baseline (3CIN2 and 1CIN3) with cumulative incidence of CIN2+ of 0.4% (95% CI: 0.1-1.4) at 5-years and 1.3% (95% CI: 0.4-3.7) at 9-years. During the first year, the prevalence among women with both tests positive was 27.0% (95% CI: 13.0-50.6) for CIN2+. Lost to follow-up was higher among women with both tests negative compared to those with both positive tests (38.7% vs 4.2%, p-value <0.001). 40.5% of the women HPV-/cyto- had a re-screening test during the 4 years following the baseline, increasing until 53.5% during the 6 years of follow-up. CONCLUSIONS: HPV detection shows a high longitudinal predictive value at 9-year to identify women at risk to develop CIN2+. The data validate a safe extension of the 3-year screening intervals (current screening interval) to 5-year intervals in underscreened women that had negative HPV result at baseline. It is necessary to establish mechanisms to ensure screening participation and adequate follow-up for these women.read more
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Iconographies supplémentaires de l'article : Patients with cervical cancer: why did screening not prevent these cases?
Roosmarie P. de Bie,Henke C. Vergers-Spooren,Leon F.A.G. Massuger,Albertus G. Siebers,Maria R.J. Salet-van der Pol,Judith E. M. Vedder,Willem J. G. Melchers,Johan Bulten,Ruud L.M. Bekkers +8 more
TL;DR: In this paper, the authors assess the screening history of women with cervical cancer and review normal cervical smears 5 years preceding the diagnosis, finding that half of the women were never screened because of the limited target age range or nonattendance.
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TL;DR: In this paper, the authors discuss the next steps and key considerations for the expansion of human papillomavirus DNA-based screening for cervical cancer prevention. But, they do not discuss the feasibility of using DNA testing in low-and middle-income countries.
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Distribution of high-risk human papillomavirus in women with ASC-US or LSIL in Tunisian women: Place of HPV testing for women triage in Tunisia.
Monia Ardhaoui,Rahima Bel Haj Rhouma,Haifa Ettounsi Guettiti,Emna Fehri,Kaouther Ouerhani,Zeineb Ben Jemia,Thalja Laassili,Ikram Guizani,M.S. Boubaker,Emna Ennaifer +9 more
TL;DR: In this paper , the distribution of oncogenic HPVs in Tunisian women diagnosed with ASC-US or LSIL in order to highlight the importance of HPV testing in the management of women with minor cytological lesions.
References
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The causal relation between human papillomavirus and cervical cancer
TL;DR: It is the right time for medical societies and public health regulators to consider the causal role of human papillomavirus infections in cervical cancer and to define its preventive and clinical implications.
Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TL;DR: The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.
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Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials
Guglielmo Ronco,Joakim Dillner,K. Miriam Elfström,Sara Tunesi,Peter J.F. Snijders,Marc Arbyn,Henry C Kitchener,Nereo Segnan,Clare Gilham,Paolo Giorgi-Rossi,Johannes Berkhof,Julian Peto,Chris J.L.M. Meijer +12 more
TL;DR: Data of large-scale randomised trials support initiation of HPV-based screening from age 30 years and extension of screening intervals to at least 5 years, and provide 60-70% greater protection against invasive cervical carcinomas compared with cytology.
Journal ArticleDOI
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk
Ganna Chornokur,Hui-Yi Lin,Jonathan Tyrer,Kate Lawrenson,Joe Dennis,Ernest K. Amankwah,Xiaotao Qu,Ya-Yu Tsai,Heather S.L. Jim,Zhihua Chen,Ann Y. Chen,Jennifer Permuth-Wey,Katja K.H. Aben,Hoda Anton-Culver,Natalia Antonenkova,Fiona Bruinsma,Elisa V. Bandera,Yukie Bean,Matthias W. Beckmann,Maria Bisogna,Line Bjørge,Natalia Bogdanova,Louise A. Brinton,Angela Brooks-Wilson,Clareann H. Bunker,Ralf Bützow,Ian G. Campbell,Karen Carty,Jenny Chang-Claude,Linda S. Cook,Daniel W. Cramer,Julie M. Cunningham,Cezary Cybulski,Agnieszka Dansonka-Mieszkowska,Andreas du Bois,Evelyn Despierre,Ed Dicks,Jennifer A. Doherty,Thilo Dörk,Matthias Dürst,Douglas F. Easton,Diana Eccles,Robert P. Edwards,Arif B. Ekici,Peter A. Fasching,Brooke L. Fridley,Yu-Tang Gao,Aleksandra Gentry-Maharaj,Graham G. Giles,Rosalind Glasspool,Marc T. Goodman,Jacek Gronwald,Patricia Harrington,Philipp Harter,Alexander Hein,Florian Heitz,Michelle A.T. Hildebrandt,Peter Hillemanns,Claus Høgdall,Estrid Høgdall,Satoyo Hosono,Anna Jakubowska,Allan Jensen,Bu-Tian Ji,Beth Y. Karlan,Linda E. Kelemen,Mellissa Kellar,Lambertus A. Kiemeney,Camilla Krakstad,Susanne K. Kjaer,Jolanta Kupryjanczyk,Diether Lambrechts,Sandrina Lambrechts,Nhu D. Le,Alice W. Lee,Shashi Lele,Arto Leminen,Jenny Lester,Douglas A. Levine,Dong Liang,Boon Kiong Lim,Jolanta Lissowska,Karen Lu,Jan Lubinski,Lene Lundvall,Leon F.A.G. Massuger,Keitaro Matsuo,Valerie McGuire,John R. McLaughlin,Iain A. McNeish,Usha Menon,Roger L. Milne,Francesmary Modugno,Kirsten B. Moysich,Roberta B. Ness,Heli Nevanlinna,Ursula Eilber,Kunle Odunsi,Sara H. Olson,Irene Orlow,Sandra Orsulic,Rachel Palmieri Weber,James Paul,Celeste Leigh Pearce,Tanja Pejovic,Liisa M. Pelttari,Malcolm C. Pike,Elizabeth M. Poole,Harvey A. Risch,Barry P. Rosen,Mary Anne Rossing,Joseph H. Rothstein,Anja Rudolph,Ingo B. Runnebaum,Iwona K. Rzepecka,Helga B. Salvesen,Eva S. Schernhammer,Ira Schwaab,Xiao-Ou Shu,Yurii B. Shvetsov,Nadeem Siddiqui,Weiva Sieh,Honglin Song,Melissa C. Southey,Beata Spiewankiewicz,Lara Sucheston,Soo-Hwang Teo,Kathryn L. Terry,Pamela J. Thompson,Lotte Ansgaard Thomsen,Ingvild L. Tangen,Shelley S. Tworoger,Anne M. van Altena,Robert A. Vierkant,Ignace Vergote,Christine Walsh,Shan Wang-Gohrke,Nicolas Wentzensen,Alice S. Whittemore,Kristine G. Wicklund,Lynne R. Wilkens,Anna H. Wu,Xifeng Wu,Yin Ling Woo,Hannah P. Yang,Wei Zheng,Argyrios Ziogas,Hanis Nazihah Hasmad,Andrew Berchuck,Edwin S. Iversen,Joellen M. Schildkraut,Susan J. Ramus,Ellen L. Goode,Alvaro N.A. Monteiro,Simon A. Gayther,Steven A. Narod,Paul D.P. Pharoah,Thomas A. Sellers,Catherine M. Phelan +158 more
TL;DR: Associations between inherited cellular transport gene variants and risk of EOC histologic subtypes are revealed on a large cohort of women.
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2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors.
Rebecca B. Perkins,Richard S. Guido,Philip E. Castle,David Chelmow,Mark H. Einstein,Francisco A.R. Garcia,Warner K. Huh,Jane J. Kim,Anna-Barbara Moscicki,Ritu Nayar,Mona Saraiya,George F. Sawaya,Nicolas Wentzensen,Mark Schiffman +13 more
TL;DR: The 2019 ASCCP Risk-Based Management Consensus Guidelines Committee concluded that the current consensus on risk-based management guidelines is inadequate and called for further work on this issue.