Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain
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TLDR
The analgesia obtained from a low dose of delta-9-tetrahydrocannabinol (1.29%) in patients, most of whom were experiencing neuropathic pain despite conventional treatments, is a clinically significant outcome and the effect sizes on cognitive testing were consistent with this minimal dose.About:
This article is published in The Journal of Pain.The article was published on 2013-02-01 and is currently open access. It has received 259 citations till now. The article focuses on the topics: Analgesic & Neuropathic pain.read more
Citations
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Adverse Health Effects of Marijuana Use
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Penny Whiting,Penny Whiting,Robert Wolff,Sohan Deshpande,Marcello Di Nisio,Steven Duffy,Adrian V. Hernandez,Adrian V. Hernandez,J. Christiaan Keurentjes,Shona H. Lang,Kate Misso,Steve Ryder,Simone Schmidlkofer,Marie Westwood,Jos Kleijnen +14 more
TL;DR: There was moderate- quality evidence to support the use of cannabinoids for the treatment of chronic pain and spasticity and low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome.
Journal ArticleDOI
Cannabis‐based medicines for chronic neuropathic pain in adults
TL;DR: To assess the efficacy, tolerability, and safety of cannabis-based medicines (herbal, plant-derived, synthetic) compared to placebo or conventional drugs for conditions with chronic neuropathic pain in adults, randomised, double-blind controlled trials are selected.
Journal ArticleDOI
Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes
Oier Aizpurua-Olaizola,Umut Soydaner,Ekin Öztürk,Daniele Schibano,Yilmaz Simsir,Patricia Navarro,Nestor Etxebarria,Aresatz Usobiaga +7 more
TL;DR: Differences in the cannabigerolic acid development among the different chemotypes and between monoterpene and sesquiterpene evolution patterns were also observed.
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Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies.
Emily Stockings,Gabrielle Campbell,Wayne Hall,Suzanne Nielsen,Dino Zagic,Rakin Rahman,Bridin Murnion,Michael Farrell,Megan Weier,Louisa Degenhardt +9 more
TL;DR: It seems unlikely that cannabinoids are highly effective medicines for CNCP, as effects suggest that number needed to treat to benefit is high, and number neededto treat to harm is low, with limited impact on other domains.
References
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Dose-dependent Effects of Smoked Cannabis on Capsaicin-induced Pain and Hyperalgesia in Healthy Volunteers
Mark S. Wallace,Gery Schulteis,J. Hampton Atkinson,Tanya Wolfson,Deborah Lazzaretto,Heather Bentley,Ben Gouaux,Ian Abramson +7 more
TL;DR: There is a window of modest analgesia for smoked cannabis, with lower doses decreasing pain and higher doses increasing pain, this study suggests.
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Comparative Effects of Alcohol and Marijuana on Mood, Memory, and Performance
TL;DR: Alcohol, but not marijuana, slightly impaired performance in a number recognition test, and both drugs produced comparable impairment in digit-symbol substitution and word recall tests, but had no effect in time perception and reaction time tests.
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IASP Diagnostic Criteria for Complex Regional Pain Syndrome: A Preliminary Empirical Validation Study
TL;DR: Data analysis suggested that CRPS decision rules may lead to overdiagnosis of the disorder and the addition of trophic tissue changes, range of motion changes, and "burning" quality of pain did not improve diagnostic accuracy, but the additions of motor neglect signs did.
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Cannabis use for chronic non-cancer pain: results of a prospective survey.
TL;DR: It is concluded that cannabis use is prevalent among the chronic non‐cancer pain population, for a wide range of symptoms, with considerable variability in the amounts used.
Journal ArticleDOI
Suicidal Behaviors in Young Adolescents
TL;DR: A two-stage epidemiologic study investigated the frequency of suicidal behavior in children 12-14 years of age and found significant relations were found between major depression and both suicide ideation and suicide attempts.