Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain
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TLDR
The analgesia obtained from a low dose of delta-9-tetrahydrocannabinol (1.29%) in patients, most of whom were experiencing neuropathic pain despite conventional treatments, is a clinically significant outcome and the effect sizes on cognitive testing were consistent with this minimal dose.About:
This article is published in The Journal of Pain.The article was published on 2013-02-01 and is currently open access. It has received 259 citations till now. The article focuses on the topics: Analgesic & Neuropathic pain.read more
Citations
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Adverse Health Effects of Marijuana Use
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Penny Whiting,Penny Whiting,Robert Wolff,Sohan Deshpande,Marcello Di Nisio,Steven Duffy,Adrian V. Hernandez,Adrian V. Hernandez,J. Christiaan Keurentjes,Shona H. Lang,Kate Misso,Steve Ryder,Simone Schmidlkofer,Marie Westwood,Jos Kleijnen +14 more
TL;DR: There was moderate- quality evidence to support the use of cannabinoids for the treatment of chronic pain and spasticity and low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome.
Journal ArticleDOI
Cannabis‐based medicines for chronic neuropathic pain in adults
TL;DR: To assess the efficacy, tolerability, and safety of cannabis-based medicines (herbal, plant-derived, synthetic) compared to placebo or conventional drugs for conditions with chronic neuropathic pain in adults, randomised, double-blind controlled trials are selected.
Journal ArticleDOI
Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes
Oier Aizpurua-Olaizola,Umut Soydaner,Ekin Öztürk,Daniele Schibano,Yilmaz Simsir,Patricia Navarro,Nestor Etxebarria,Aresatz Usobiaga +7 more
TL;DR: Differences in the cannabigerolic acid development among the different chemotypes and between monoterpene and sesquiterpene evolution patterns were also observed.
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Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies.
Emily Stockings,Gabrielle Campbell,Wayne Hall,Suzanne Nielsen,Dino Zagic,Rakin Rahman,Bridin Murnion,Michael Farrell,Megan Weier,Louisa Degenhardt +9 more
TL;DR: It seems unlikely that cannabinoids are highly effective medicines for CNCP, as effects suggest that number needed to treat to benefit is high, and number neededto treat to harm is low, with limited impact on other domains.
References
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Journal ArticleDOI
Practice effects and the use of alternate forms in serial neuropsychological testing
Leigh J. Beglinger,Brenda Gaydos,Oranee Tangphao-Daniels,Kevin Duff,David A. Kareken,Jane Crawford,Philip S. Fastenau,Eric Siemers +7 more
TL;DR: Serial assessment with alternate forms may attenuate retest effects on some tests, but continued learning occurs on novel tests or those in which an advantageous test-taking strategy can be identified.
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Acupuncture and Amitriptyline for Pain Due to HIV-Related Peripheral Neuropathy: A Randomized Controlled Trial
Judith C. Shlay,Kathryn Chaloner,Mitchell B. Max,Bob Flaws,Patricia Reichelderfer,Deborah Wentworth,Shauna Hillman,Barbara Brizz,David L. Cohn +8 more
TL;DR: Neither acupuncture nor amitriptyline was more effective than placebo in relieving pain caused by HIV-related peripheral neuropathy in HIV-infected patients.
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A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain
Barth L. Wilsey,Thomas D. Marcotte,Alexander Tsodikov,Jeanna Millman,Heather Bentley,Ben Gouaux,Scott M. Fishman +6 more
TL;DR: This study adds to a growing body of evidence that cannabis may be effective at ameliorating neuropathic pain, and may be an alternative for patients who do not respond to, or cannot tolerate, other drugs, however, the use of marijuana as medicine may be limited by its method of administration and modest acute cognitive effects, particularly at higher doses.
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Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users
Johannes G. Ramaekers,Gerold F. Kauert,Eef L. Theunissen,Stefan W. Toennes,Manfred R. Moeller +4 more
TL;DR: The data indicate that cannabis use history strongly determines the behavioural response to single doses of THC, and THC significantly impaired performance of occasional cannabis users on critical tracking, divided attention and the stop signal task.
Journal ArticleDOI
Use of anticonvulsants for treatment of neuropathic pain
TL;DR: Evidence supporting the efficacy of anticonvulsants in treatment of such pain is evolving, and additional clinical trials should provide information that will better define their role in neuropathic pain.