Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain
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TLDR
The analgesia obtained from a low dose of delta-9-tetrahydrocannabinol (1.29%) in patients, most of whom were experiencing neuropathic pain despite conventional treatments, is a clinically significant outcome and the effect sizes on cognitive testing were consistent with this minimal dose.About:
This article is published in The Journal of Pain.The article was published on 2013-02-01 and is currently open access. It has received 259 citations till now. The article focuses on the topics: Analgesic & Neuropathic pain.read more
Citations
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Adverse Health Effects of Marijuana Use
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Penny Whiting,Penny Whiting,Robert Wolff,Sohan Deshpande,Marcello Di Nisio,Steven Duffy,Adrian V. Hernandez,Adrian V. Hernandez,J. Christiaan Keurentjes,Shona H. Lang,Kate Misso,Steve Ryder,Simone Schmidlkofer,Marie Westwood,Jos Kleijnen +14 more
TL;DR: There was moderate- quality evidence to support the use of cannabinoids for the treatment of chronic pain and spasticity and low-quality evidence suggesting that cannabinoids were associated with improvements in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome.
Journal ArticleDOI
Cannabis‐based medicines for chronic neuropathic pain in adults
TL;DR: To assess the efficacy, tolerability, and safety of cannabis-based medicines (herbal, plant-derived, synthetic) compared to placebo or conventional drugs for conditions with chronic neuropathic pain in adults, randomised, double-blind controlled trials are selected.
Journal ArticleDOI
Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes
Oier Aizpurua-Olaizola,Umut Soydaner,Ekin Öztürk,Daniele Schibano,Yilmaz Simsir,Patricia Navarro,Nestor Etxebarria,Aresatz Usobiaga +7 more
TL;DR: Differences in the cannabigerolic acid development among the different chemotypes and between monoterpene and sesquiterpene evolution patterns were also observed.
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Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies.
Emily Stockings,Gabrielle Campbell,Wayne Hall,Suzanne Nielsen,Dino Zagic,Rakin Rahman,Bridin Murnion,Michael Farrell,Megan Weier,Louisa Degenhardt +9 more
TL;DR: It seems unlikely that cannabinoids are highly effective medicines for CNCP, as effects suggest that number needed to treat to benefit is high, and number neededto treat to harm is low, with limited impact on other domains.
References
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Hyperalgesia and allodynia
TL;DR: Background and peripheral mechanisms of nociceptor sensitization characteristics and mechanisms of primary hyperalgesia mechanisms of secondary hyperAlgesia role of central changes in hyperalgersia clinical aspects of hyperalGESia and future research directions are studied.
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Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial.
David M. Simpson,Justin C. McArthur,Richard K. Olney,David B. Clifford,Yuen T. So,David M. Ross,B. J. Baird,P. Barrett,Anne E. Hammer,Richard S. Baker,Russell Bartt,S. Becker,Joseph R. Berger,Thomas H. Brannagan,Bruce A. Cohen,C. Dorko,Ronald J. Ellis,D. M. Feinberg,K. Goodkin,Colin D. Hall,Princy Kumar,Camillo Marra,Richard B. Pollard,Giovanni Schifitto,Alex Tselis,K. Vollmer +25 more
TL;DR: Lamotrigine was well-tolerated and effective for HIV-associated neuropathic pain in patients receiving neurotoxic antiretroviral therapy, and patient and clinician ratings of global impression of change in pain were similar.
Journal ArticleDOI
Abstinence symptoms following oral THC administration to humans.
TL;DR: Behavioral changes indicate that dependence develops following exposure to lower daily doses of THC than have been previously studied, suggesting that the alleviation of abstinence symptoms may contribute to the maintenance of daily marijuana use.
Journal ArticleDOI
Pregabalin in patients with central neuropathic pain: a randomized, double-blind, placebo-controlled trial of a flexible-dose regimen.
J. H. Vranken,Marcel G. W. Dijkgraaf,M R Kruis,M H van der Vegt,Markus W. Hollmann,M. Heesen +5 more
TL;DR: Pregabalin, in a flexible‐dose regime, produced clinically significant reductions in pain, as well as improvements in health status in patients suffering from severe central neuropathic pain.
Journal ArticleDOI
Vaporization as a smokeless cannabis delivery system: a pilot study.
Donald I. Abrams,Donald I. Abrams,H. Vizoso,H. Vizoso,Starley B. Shade,Starley B. Shade,C. A. Jay,C. A. Jay,M E Kelly,M E Kelly,Neal L. Benowitz +10 more
TL;DR: Vaporization of cannabis is a safe and effective mode of delivery of THC and further trials of clinical effectiveness of cannabis could utilize vaporization as a smokeless delivery system.