Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain
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TLDR
The analgesia obtained from a low dose of delta-9-tetrahydrocannabinol (1.29%) in patients, most of whom were experiencing neuropathic pain despite conventional treatments, is a clinically significant outcome and the effect sizes on cognitive testing were consistent with this minimal dose.About:
This article is published in The Journal of Pain.The article was published on 2013-02-01 and is currently open access. It has received 259 citations till now. The article focuses on the topics: Analgesic & Neuropathic pain.read more
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Cannabinoid interactions with ion channels and receptors.
TL;DR: This review will outline the studies that report reproducible results of CBD and other cannabinoids changing membrane channel function, with particular interest on voltage-gated sodium channel (Nav), which is implicated in fatal forms of epilepsy and are also associated with chronic pain.
Journal ArticleDOI
Opportunities for cannabis in supportive care in cancer.
Amber S. Kleckner,Ian R. Kleckner,Charles Kamen,Mohamedtaki Abdulaziz Tejani,Michelle C. Janelsins,Gary R. Morrow,Luke J. Peppone +6 more
TL;DR: There is a reasonable amount of evidence to consider cannabis for nausea and vomiting, loss of appetite, and pain as a supplement to first-line treatments, and promising evidence to treat chemotherapy-induced peripheral neuropathy, gastrointestinal distress, and sleep disorders, but the literature is thus far too limited to recommend cannabis for these symptoms.
Journal ArticleDOI
Gender differences among treatment-seeking adults with cannabis use disorder: Clinical profiles of women and men enrolled in the achieving cannabis cessation-evaluating N-acetylcysteine treatment (ACCENT) study.
Brian J. Sherman,Aimee L. McRae-Clark,Nathaniel L. Baker,Susan C. Sonne,Therese K. Killeen,Kasie Cloud,Kevin M. Gray +6 more
TL;DR: Cannabis-dependent women may benefit from integrated treatment focusing on co-occurring psychiatric disorders and targeted treatment of cannabis withdrawal syndrome, and may help explain recent evidence suggesting that women fare worse than men in cannabis treatment trials of pharmacologic interventions.
Journal ArticleDOI
Opioid and cannabinoid synergy in a mouse neuropathic pain model.
Nicholas P. Kazantzis,Sherelle L. Casey,Patrick W. Seow,Vanessa A. Mitchell,Christopher W. Vaughan +4 more
TL;DR: The effect of combination treatment with cannabinoid and opioid receptor agonists on allodynia and side effects in a nerve injury‐induced neuropathic pain model is examined.
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Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale
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Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage
TL;DR: Treatment needs to move from merely suppressing symptoms to a disease-modifying strategy aimed at both preventing maladaptive plasticity and reducing intrinsic risk.