Lymph Node Stroma Dynamics and Approaches for Their Visualization.
Rebecca Gentek,Marc Bajénoff +1 more
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TLDR
The function of the major lymphoid stromal cell types; the way they remodel upon inflammation; the available tools to track their behavior; and several methodological approaches are introduced that are believed to help improving knowledge of these pivotal cell types.About:
This article is published in Trends in Immunology.The article was published on 2017-04-01 and is currently open access. It has received 17 citations till now.read more
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Journal ArticleDOI
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes
Joern Pezoldt,Maria Pasztoi,Mangge Zou,Carolin Wiechers,Michael Beckstette,Guilhem R. Thierry,Ehsan Vafadarnejad,Stefan Floess,Panagiota Arampatzi,Manuela Buettner,Janina Schweer,Diana Fleissner,Marius Vital,Dietmar H. Pieper,Marijana Basic,Petra Dersch,Till Strowig,Mathias W. Hornef,André Bleich,Ulrike Bode,Oliver Pabst,Marc Bajénoff,Antoine-Emmanuel Saliba,Jochen Huehn +23 more
TL;DR: It is shown that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, location-specific transcriptional programs for the induction of regulatory T cells and peripheral tolerance.
Book ChapterDOI
Role of iBALT in Respiratory Immunity.
TL;DR: The activity of iBALT is demonstrably beneficial for the clearance of respiratory pathogens; however, it is less clear whether it dampens or exacerbates inflammatory responses to non-infectious agents.
Journal ArticleDOI
Lymphoid Tissue inducer (LTi) cell ontogeny and functioning in embryo and adult.
TL;DR: This review will evaluate the embryonic LTi cell origin from a specific embryonic hemogenic wave, which has recently been described in mouse and discuss their differentiation and similarities with the closely related ILC3 cells in embryo and adult.
Posted ContentDOI
Acute lymph node slices are a functional model system to study immunity ex vivo
Maura C. Belanger,Andrew W.L. Kinman,Andrew W.L. Kinman,Megan A. Catterton,Megan A. Catterton,Alexander G. Ball,Benjamin D. Groff,Benjamin D. Groff,Stephanie J. Melchor,John R. Lukens,Ashley E. Ross,Rebecca R. Pompano,Rebecca R. Pompano +12 more
TL;DR: Lymph node slices provide a versatile platform to investigate immune functions in spatially organized tissue, enabling well-defined stimulation, time-course analysis, and parallel read-outs.
Journal ArticleDOI
Acute Lymph Node Slices Are a Functional Model System to Study Immunity Ex Vivo.
Maura C. Belanger,Maura C. Belanger,Alexander G. Ball,Megan A. Catterton,Andrew W.L. Kinman,Parastoo Anbaei,Benjamin D. Groff,Stephanie J. Melchor,John R. Lukens,Ashley E. Ross,Rebecca R. Pompano,Rebecca R. Pompano +11 more
TL;DR: In this paper, live murine lymph node slices were collected under optimized conditions and compared to cell suspensions in terms of both 24-h viability and inflammation, and showed that the slices responded to T cell receptor cross-linking with increased surface marker expression and cytokine secretion.
References
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Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication
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Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
Jean Livet,Tamily A. Weissman,Hyuno Kang,Ju Lu,Robyn A Bennis,Joshua R. Sanes,Jeff W. Lichtman +6 more
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Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
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A chemical method for fast and sensitive detection of DNA synthesis in vivo
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Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Elisa Gomez Perdiguero,Kay Klapproth,Christian Schulz,Katrin Busch,Emanuele Azzoni,Lucile Crozet,Hannah Garner,Céline Trouillet,Marella F. T. R. de Bruijn,Frederic Geissmann,Hans Reimer Rodewald +10 more
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