Journal ArticleDOI
Magnetosomes, biogenic magnetic nanomaterials for brain molecular imaging with 17.2 T MRI scanner.
Sébastien Mériaux,Marianne Boucher,Benjamin Marty,Yoann Lalatonne,Sandra Prévéral,Laurence Motte,Christopher T. Lefèvre,Françoise Geffroy,Franck Lethimonnier,Michel Pean,Daniel Garcia,Géraldine Adryanczyk-Perrier,David Pignol,Nicolas Ginet +13 more
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TLDR
Preclinical studies of human pathologies in animal models will benefit from the combination of high magnetic field MRI with sensitive, low dose, easy‐to‐produce biocompatible contrast agents derived from bacterial magnetosomes.Abstract:
The fast development of sensitive molecular diagnostic tools is currently paving the way for a personalized medicine. A new class of ultrasensitive magnetic resonance imaging (MRI) T₂-contrast agents based on magnetosomes, magnetite nanocrystals biomineralized by magnetotactic bacteria, is proposed here. The contrast agents can be injected into the blood circulation and detected in the picomolar range. Purified magnetosomes are water-dispersible and stable within physiological conditions and exhibit at 17.2 T a transverse relaxivity r₂ four times higher than commercial ferumoxide. The subsequent gain in sensitivity by T₂(*) -weighted imaging at 17.2 T of the mouse brain vasculature is evidenced in vivo after tail vein injection of magnetosomes representing a low dose of iron (20 μmoliron kg(-1)), whereas no such phenomenon with the same dose of ferumoxide is observed. Preclinical studies of human pathologies in animal models will benefit from the combination of high magnetic field MRI with sensitive, low dose, easy-to-produce biocompatible contrast agents derived from bacterial magnetosomes.read more
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Journal ArticleDOI
Magnetosome biogenesis in magnetotactic bacteria
René Uebe,Dirk Schüler +1 more
TL;DR: This Review discusses the diverse properties of magnetosome biogenesis in other species of magnetotactic bacteria and considers the value of genetically 'magnetizing' non-magnetotacticacteria.
Journal ArticleDOI
Anisotropic magnetic nanoparticles: A review of their properties, syntheses and potential applications
Darja Lisjak,Alenka Mertelj +1 more
TL;DR: In this paper, the authors focus on anisotropic magnetic nanoparticles that exhibit (i) elongated shapes and (ii) plate-like shapes, and present the potential applications of these new, multi-functional materials with future perspectives.
Journal ArticleDOI
Targeted thermal therapy with genetically engineered magnetite magnetosomes@RGD: Photothermia is far more efficient than magnetic hyperthermia
Anouchka Plan Sangnier,Sandra Prévéral,Alberto Curcio,Amanda K. A. Silva,Chistopher T. Lefèvre,David Pignol,Yoann Lalatonne,Claire Wilhelm +7 more
TL;DR: It is demonstrated that targeted magnetic nanoparticles could generate heat on a therapeutic level after systemic administration, but only under laser excitation, and successfully inhibit tumor progression.
Journal ArticleDOI
Applications of Magnetotactic Bacteria, Magnetosomes and Magnetosome Crystals in Biotechnology and Nanotechnology: Mini-Review.
Gabriele Vargas,Jefferson Cypriano,Tarcisio Correa,Pedro Leão,Dennis A. Bazylinski,Fernanda Abreu +5 more
TL;DR: Metric analysis using Scopus and Web of Science databases from 2003 to 2018 showed that applied research involving magnetite from MTB in some form has been focused mainly in biomedical applications, particularly in magnetic hyperthermia and drug delivery.
Journal ArticleDOI
Genetically tailored magnetosomes used as MRI probe for molecular imaging of brain tumor
Marianne Boucher,Françoise Geffroy,Sandra Prévéral,L. Bellanger,Erwan Selingue,Géraldine Adryanczyk-Perrier,Michel Pean,Christopher T. Lefèvre,David Pignol,Nicolas Ginet,Sébastien Mériaux +10 more
TL;DR: The first proof-of-concept of a successful bio-integrated production of molecular imaging probe for MRI is established, establishing the potential of single step production of genetically engineered magnetosomes, bacterial biogenic iron-oxide nanoparticles embedded in a lipid vesicle, as a new tailorable magnetic resonance molecular Imaging probe.
References
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Book ChapterDOI
Muliscale Vessel Enhancement Filtering
TL;DR: The multiscale second order local structure of an image (Hessian) is examined with the purpose of developing a vessel enhancement filter and a vesselness measure is obtained.
Journal ArticleDOI
Strategies in the design of nanoparticles for therapeutic applications
TL;DR: This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles.
Journal ArticleDOI
Imaging in the era of molecular oncology
TL;DR: Advances in experimental and clinical imaging are likely to improve how cancer is understood at a systems level and should enable doctors not only to locate tumours but also to assess the activity of the biological processes within these tumours and to provide 'on the spot' treatment.
Journal ArticleDOI
What vibrations tell us about proteins
Andreas Barth,Christian Zscherp +1 more
TL;DR: This review deals with current concepts of vibrational spectroscopy for the investigation of protein structure and function, namely the amide I vibration of the polypeptide backbone that is used for secondary-structure analysis and some of the general aspects also apply to RamanSpectroscopy.
Journal ArticleDOI
Recent advances in iron oxide nanocrystal technology for medical imaging
TL;DR: Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models.