Mammalian Oocytes Locally Remodel Follicular Architecture to Provide the Foundation for Germline-Soma Communication
TLDR
It is shown that TZP number and germline-soma communication are strikingly reduced in reproductively aged females, and an inability of somatic follicle cells to respond appropriately to oocyte-derived cues may contribute to human infertility.About:
This article is published in Current Biology.The article was published on 2018-04-02 and is currently open access. It has received 70 citations till now. The article focuses on the topics: Germ cell & Oocyte.read more
Citations
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Coordination of Ovulation and Oocyte Maturation: A Good Egg at the Right Time.
TL;DR: Ovulation is tightly linked with oocyte maturation, demonstrating the interdependency of these two parallel processes, both essential for female fertility, and recent discoveries in regulation of ovulation highlight new areas of investigation.
Journal Article
Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovary
Patricia Da Silva-Buttkus,Gayani Jayasooriya,Jocelyn M. Mora,Margaret A. Mobberley,Timothy A. Ryder,Marianne Baithun,Jaroslav Stark,Stephen Franks,Kate Hardy +8 more
TL;DR: It is proposed that the basement membrane and/or theca cells that surround the follicle provide an important confinement for rapidly dividing columnar cells so that they attain maximum packing density, which restricts lateral mitosis and promotes inwardly oriented cell divisions and subsequent multilayering.
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Interaction between growing oocytes and granulosa cells in vitro
TL;DR: The growth culture system of oocytes has been improved, further promoting the studies on the communication between oocytes and granulosa cells in vitro.
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Segregating Chromosomes in the Mammalian Oocyte.
TL;DR: An overview of the chromosome-segregation process in the mammalian oocyte is provided, highlighting mechanistic differences between oocytes and somatic cells that render oocytes so prone to segregation error.
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Three-dimensional organization of transzonal projections and other cytoplasmic extensions in the mouse ovarian follicle
Valentina Baena,Mark Terasaki +1 more
TL;DR: It is proposed that granulosa cells use cytoplasmic projections to search for the oocyte, and cumulus cell differentiation results from a contact-mediated paracrine interaction with the oocytes.
References
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Growth differentiation factor-9 is required during early ovarian folliculogenesis
TL;DR: Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised, and GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo.
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Intercellular Communication in the Mammalian Ovary: Oocytes Carry the Conversation
TL;DR: It is established that bidirectional communication between the oocyte and companion somatic cells is essential for development of an egg competent to undergo fertilization and embryogenesis and the challenge for the future is to identify the factors that participate in this communication and their mechanisms of action.
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Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
TL;DR: A new perspective on oocyte-CC interactions is improving knowledge of the processes regulating oocyte quality, which is likely to have a number of applications, including improving the efficiency of clinical IVM and thereby providing new options for the treatment of infertility.
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Human aneuploidy: mechanisms and new insights into an age-old problem
TL;DR: New studies of humans and model organisms have shed new light on the complexity of meiotic defects, providing evidence that the age-related increase in errors in the human female is not attributable to a single factor but to an interplay between unique features of oogenesis and a host of endogenous and exogenous factors.
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Female infertility in mice lacking connexin 37
TL;DR: It is shown that connexin 37 is present in gap junctions between oocyte and granulosa cells and that Connexin-37-deficient mice lack mature (Graafian) follicles, fail to ovulate and develop numerous inappropriate corpora lutea.
Related Papers (5)
Female infertility in mice lacking connexin 37
The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte
Rong Li,David F. Albertini +1 more